Disease relevance of Sickle Cell Trait

• Treatment of sickle cell trait hematuria with oral urea [1].
• High-resolution image analysis was employed in the analysis of round (discoid) erythrocytes from hematologically normal (AA) individuals, AA individuals with nonspecific anemia, individuals with sickle cell trait (AS), individuals with SC disease (SC), and individuals with sickle cell anemia (SS) [2].
• However, the differences in metHb reductase activities in patients with sickle cell trait, G6PD deficiency, and low MCV < 80 micron3 (presumptively having alpha-thalassemia) in small subgroups did not reach statistical significance (p = 0.2), although, all 3 groups were comprised of small numbers [3].
• IMPLICATIONS: We describe prolonged drowsiness proceeding to hepatic encephalopathy in a child with sickle cell trait and carnitine palmitoyltransferase deficiency [4].
• The alpha-adrenergic agonist etilefrine (50-100 mg/d) produced a good clinical response in 13 of 18 (72%) adults who have recurrent priapism; 17 had SCD and one sickle cell trait [5].

High impact information on Sickle Cell Trait

• The overall frequency of sickle-cell trait was 7.8 per cent and of glucose-6-phosphate dehydrogenase dificiency 11.2 per cent [6].
• Ouabain-resistant Rb/K influx was also greater than in normal controls or patients with sickle cell trait [7].
• The D.N.A. from amniotic-fluid cells produced both the 7.6 and the 13.0 bk beta-globin gene fragments, indicating the diagnosis of sickle-cell trait [8].
• Pulmonary function in sickle cell trait [9].
• There is also a high prevalence of an independent Swiss type hereditary persistence of fetal hemoglobin (HPFH) determinant active in both the sickle cell trait and in sickle cell disease [10].

Chemical compound and disease context of Sickle Cell Trait

• Nine sickle cell trait and nine control subjects underwent six-hour ammonium chloride acid loading [11].
• PnA peroxidation in erythrocytes from sickle cell trait individuals (AS: 30 +/- 3% (n = 4)) was equal to that in control cells [12].
• Blood lactate concentrations during incremental exercise in subjects with sickle cell trait [13].
• Decreased insulin response to glucose in sickle cell trait [14].
• This is a report of disseminated placental infarcts associated with thiamine deficiency in a patient with the sickle cell trait [15].

Biological context of Sickle Cell Trait

• The different metHb reductase activity in Blacks seems to be unrelated to the presence of G6PD deficiency, sickle cell trait, or alpha-thalassemia and it may be the result of genetic polymorphism [3].
• In contrast to the sickle cell trait, the TNF alpha promotor polymorphism appeared not to have any protective effect on malaria in this study, and its importance in other unspecified fever-causing diseases in this population needs further investigation [16].
• Blood pressure and other cardiovascular disease risk factors in black adults with sickle cell trait or glucose-6-phosphate dehydrogenase deficiency [17].
• The reactivity of human erythrocytes with anti-I and anti-i sera was estimated in 36 normal adults, 18 individuals with sickle cell anemia and 27 individuals with sickle cell trait, by quantitative hemagglutination with a sensitive autoanalyzer system [18].
• We studied a black family which presented with both ADPKD and sickle-cell trait (SA) to determine which ADPKD gene was present in this family, and to examine linkage between the ADPKD in this family and markers for the beta-hemoglobin gene on chromosome 11 [19].

Anatomical context of Sickle Cell Trait

• IMPLICATIONS: Fast-track cardiac anesthesia can be used safely in patients with sickle cell trait undergoing first-time coronary artery bypass graft surgery [20].

Gene context of Sickle Cell Trait

• The arithmetic means of these adjusted parasite densities (MAPD) were not influenced by sickle cell trait nor by G6PD enzyme activity [21].
• A novel deletion of at least 26 kilobase of DNA, including both alpha-globin genes, the psi alpha- and psi zeta-globin genes, but sparing the functional zeta-gene was found in a 10-year-old black boy with HbH disease and sickle cell trait [22].
• Sickle cell trait and ABO blood group was not associated with Hp levels in this population [23].
• Structural anomalies were detected on routine ultrasound of the pregnancy of a 17-year-old G3 P1 TAB1 woman with sickle cell trait [24].
• Genetic studies in a black family with autosomal dominant polycystic kidney disease and sickle-cell trait [19].

Analytical, diagnostic and therapeutic context of Sickle Cell Trait

• In a cross-sectional study, 180 young Gabonese children with and without sickle cell trait and harboring asymptomatic Plasmodium falciparum infections, were assessed for the responses to recombinant protein containing the conserved region of glutamate-rich protein (GLURP) [25].
• Serum and erythrocyte folate contents were measured microbiologically in patients with sickle cell anaemia as well as in two control groups with sickle cell trait or normal haemoglobin pattern [26].

References