The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Circupon     3-(2-ethylamino-1-hydroxy- ethyl)phenol

Synonyms: Effortil, Phetanol, Thomasin, Etilefrin, Fetanol, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Etilefrine

  • Treatment of partial priapism with an intracavernous injection of etilefrine [1].
  • CONCLUSIONS: Oral etilefrine is not superior to placebo in preventing spontaneous episodes of vasovagal syncope [2].
  • METHODS AND RESULTS: In the 20 participating centers, 126 patients with recurrent vasovagal syncope (at least 3 episodes in the last 2 years) and a positive baseline head-up tilt response were randomly assigned to placebo (63 patients) or etilefrine at a dosage of 75 mg/d (63 patients) and were followed up for 1 year or until syncope recurred [2].
  • METHODS: Continuous electrocardiogram and noninvasive blood pressure were recorded in 24 patients scheduled for elective inguinal hernia repair and randomly assigned to three groups: (1) no volume loading, (2) volume loading of 15 ml/kg lactated Ringer's solution, and (3) continuous infusion of etilefrine (an ephedrine-like drug) [3].
  • After a follow-up of 1-48 months, none of the 18 people on etilefrine developed hypertension or sexual dysfunction [4].
 

High impact information on Etilefrine

 

Chemical compound and disease context of Etilefrine

 

Biological context of Etilefrine

 

Anatomical context of Etilefrine

 

Associations of Etilefrine with other chemical compounds

 

Analytical, diagnostic and therapeutic context of Etilefrine

  • This was a randomized double-blind crossover study of etilefrine versus placebo in 30 consecutive patients with syncope and a baseline positive head-up tilt test [25].
  • The treatment consists of preventive oral administration of the alpha-adrenergic agent etilefrine, and self-administered intracavernous injection (SICI) of the same agent to reverse episodes lasting more than 1 hour [26].
  • Intraoperative characteristics in patients with postoperative DVT were tachycardia (P < 0.001), enhanced need for etilefrine (P < 0.01) and a more rapid increase in big toe temperature (P < 0.05) after induction of epidural analgesia, compared with patients without DVT [27].
  • The reflex recovery in blood pressure was complete and the pressure sometimes exceeded the resting level by up to 10 mmHg during LBNP after salbutamol, etilefrine (50 micrograms/kg only) and dextran [11].
  • The fall in systolic arterial pressure and mean arterial pressure was significantly greater in the control group than in the etilefrine group (P < 0.05) [28].

References

  1. Treatment of partial priapism with an intracavernous injection of etilefrine. Albrecht, W., Stackl, W. JAMA (1997) [Pubmed]
  2. Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope: a double-blind, randomized, placebo-controlled trial. The Vasovagal Syncope International Study. Raviele, A., Brignole, M., Sutton, R., Alboni, P., Giani, P., Menozzi, C., Moya, A. Circulation (1999) [Pubmed]
  3. Sympathovagal effects of spinal anesthesia assessed by the spontaneous cardiac baroreflex. Gratadour, P., Viale, J.P., Parlow, J., Sagnard, P., Counioux, H., Bagou, G., Annat, G., Hughson, R., Quintin, L. Anesthesiology (1997) [Pubmed]
  4. Etilefrine for the prevention of priapism in adult sickle cell disease. Okpala, I., Westerdale, N., Jegede, T., Cheung, B. Br. J. Haematol. (2002) [Pubmed]
  5. Apical uptake of choline and cationic drugs in epithelial cell lines derived from human placenta. Müller, J., Born, I., Neubert, R.H., Brandsch, M. Placenta (2005) [Pubmed]
  6. The comparison of hypertonic saline (7.5%) and normal saline (0.9%) for initial fluid administration before spinal anesthesia. Järvelä, K., Honkonen, S.E., Järvelä, T., Kööbi, T., Kaukinen, S. Anesth. Analg. (2000) [Pubmed]
  7. Effect of ephedrine on auditory-evoked potentials during light general anaesthesia. Mori, M., Yamamoto, H., Hattori, S., Miyakawa, H., Noguchi, T. Anaesthesia. (2000) [Pubmed]
  8. Detection of oxilofrine in plasma and urine by high-performance liquid chromatography with electrochemical detection and comparison with gas chromatography-mass spectrometry. Kauert, G., Herrle, I., Schoppek, B. J. Chromatogr. (1988) [Pubmed]
  9. Randomized clinical trials of neurally mediated syncope. Brignole, M. J. Cardiovasc. Electrophysiol. (2003) [Pubmed]
  10. Usefulness of head-up tilt test in evaluating patients with syncope of unknown origin and negative electrophysiologic study. Raviele, A., Gasparini, G., Di Pede, F., Delise, P., Bonso, A., Piccolo, E. Am. J. Cardiol. (1990) [Pubmed]
  11. A comparison of the effects of salbutamol, etilefrine and dextran during hypotension and low cardiac output states in rabbit. Adigun, S.A., Fentem, P.H. Clin. Exp. Pharmacol. Physiol. (1984) [Pubmed]
  12. Isobaric 0.5% bupivacaine in spinal anaesthesia. Nuutinen, L.S., Kangas, T. Annales chirurgiae et gynaecologiae. (1980) [Pubmed]
  13. Effect of midodrine on chlorpromazine-induced orthostatic hypotension in rabbits: comparison with amezinium, etilefrine and droxidopa. Kurihara, J., Takata, Y., Suzuki, S., Okubo, Y., Kato, H. Biol. Pharm. Bull. (2000) [Pubmed]
  14. The cardiovascular effects of etilefrine. Coleman, A.J., Leary, W.P., Asmal, A.C. Eur. J. Clin. Pharmacol. (1975) [Pubmed]
  15. Dihydroergotamine increases the bioavailability of orally administered etilefrine. Hengstmann, J.H., Hengstmann, R., Schwonzen, S., Dengler, H.J. Eur. J. Clin. Pharmacol. (1982) [Pubmed]
  16. Dihydroergotamine decreases the blood content in the skeletal musculature but etilefrine hydrochloride in the splanchnic region in man. Arndt, J.O., Höck, A., Inoue, K. Basic Res. Cardiol. (1984) [Pubmed]
  17. The effects of etilefrine on blood vessels in the rat tail. Frost, B.R., Frewin, D.B., Gerke, D.C. J. Pharm. Pharmacol. (1977) [Pubmed]
  18. Successful management of post-esophagectomy chylothorax/chyloperitoneum by etilefrine. Guillem, P., Billeret, V., Houcke, M.L., Triboulet, J.P. Dis. Esophagus (1999) [Pubmed]
  19. The effect of etilefrine (Effortil) on central hemodynamics and aorto-coronary bypass blood flow. A pre-operative study. Ekeström, S., Liljeqvist, L., Lothigius, B., Nordhus, O. The Thoracic and cardiovascular surgeon. (1979) [Pubmed]
  20. Pharmacological analysis of positive chronotropic and inotropic responses to etilefrine in isolated dog heart preparations. Karasawa, Y., Furukawa, Y., Murakami, M., Ren, L.M., Takayama, S., Chiba, S. Heart and vessels. (1992) [Pubmed]
  21. Formation of a direct mutagen, diazo-N-nitrosoetilefrin, by interaction of etilefrin with nitrite. Kikugawa, K., Kato, T., Takeda, Y. Chem. Pharm. Bull. (1989) [Pubmed]
  22. Etilefrine and amezinium reduce uterine blood flow of pregnant guinea pigs. Hohmann, M., Künzel, W. Eur. J. Obstet. Gynecol. Reprod. Biol. (1989) [Pubmed]
  23. Pharmacokinetic comparison of etilefrine to its prodrug, the stearic acid ester of etilefrine. Rominger, K.L., Hitzenberger, G. International journal of clinical pharmacology, therapy, and toxicology. (1980) [Pubmed]
  24. The action of relaxin, fenoterol and etilefrine on uterine motility of the rat. Lippert, T.H., Schneider-Zeh, S., Voelter, W. International journal of clinical pharmacology, therapy, and toxicology. (1987) [Pubmed]
  25. Limitations of head-up tilt test for evaluating the efficacy of therapeutic interventions in patients with vasovagal syncope: results of a controlled study of etilefrine versus placebo. Moya, A., Permanyer-Miralda, G., Sagrista-Sauleda, J., Carne, X., Rius, T., Mont, L., Soler-Soler, J. J. Am. Coll. Cardiol. (1995) [Pubmed]
  26. Preventive treatment of priapism in sickle cell disease with oral and self-administered intracavernous injection of etilefrine. Virag, R., Bachir, D., Lee, K., Galacteros, F. Urology (1996) [Pubmed]
  27. Effect of dihydroergotamine on leg blood flow during combined epidural and general anaesthesia and postoperative deep vein thrombosis after cholecystectomy. Hendolin, H., Poikolainen, E., Mattila, M.A., Alhava, E., Hänninen, A., Puttonen, E., Kataja, M. Acta anaesthesiologica Scandinavica. (1993) [Pubmed]
  28. The effect of oral etilefrine premedication on the incidence of hypotension during spinal anaesthesia. Bouaggad, A., Harrar, R.A., Bouderka, M.A., Abassi, O. European journal of anaesthesiology. (2000) [Pubmed]
 
WikiGenes - Universities