Disease relevance of Schistosomiasis haematobia

• From 1982 to 1984 170 children of Kikwawila village (Kilombero district, Tanzania) were followed for nutritional (anthropometric measures, hematocrit, serum retinol, prealbumin, and zinc concentrations), parasitological (malaria parasitemia, urinary schistosomiasis, intestinal parasites) and immunological characteristics [1].
• The efficacy of oltipraz as a schistosomicidal drug was investigated in Gabonese children suffering from urinary schistosomiasis in the dosages of 1 X 25 mg/kg body weight, 1 X 35 mg/kg body weight, and 2 X 20 mg/kg body weight and compared to praziquantel, 2 X 30 mg/kg body weight [2].

High impact information on Schistosomiasis haematobia

• Thus, enhanced SWAP-driven IL-4 and IL-5 production correlates with immunity to reinfection in adolescents exposed to urinary schistosomiasis [3].
• Trichlorfon (metrifonate) was given intermittently to 37 schoolboys with urinary schistosomiasis living in a hyperendemic area of the Sudan. Patients were followed up for three years [4].
• This inverse relationship between degree of infection by S. haematobium and iron status shows a deleterious consequence of urinary schistosomiasis on nutrition and hematopoietic status, which should be considered in the design of nutrition intervention programs [5].
• Renal function was assessed in 101 schoolchildren with active urinary schistosomiasis by measuring serum creatinine, urate, urea, and B2-microglobulin, urinary B2 microglobulin, and the glomerular filtration rate [6].
• Further analysis of the data obtained from 190 unselected autopsies at the University of Cairo (Faculty of Medicine) hospitals reinforces our conclusion that a high prevalence of urinary schistosomiasis leads to infection intensity causing severe uropathy and mortality, both directly and by way of complications and sequelae [7].

Chemical compound and disease context of Schistosomiasis haematobia

• Applicability of a monoclonal antibody-based dipstick in diagnosis of urinary schistosomiasis in the Central Region of Ghana [8].
• The oral treatment of urinary schistosomiasis in Egyptian patients with 'Oltipraz' [9].
• The side-effects of niridazole used for urinary schistosomiasis were studied prospectively over a 3-month period in male patients receiving the standard dose of 25 mg day-1 kg-1 for 7 days [10].
• Chronic urinary schistosomiasis: patterns of abnormalities in radionuclide Tc-99 m DTPA diuretic renogram [11].
• Progress of the control of urinary schistosomiasis among school-children in Iraq by selective mass treatment campaign with etrenol in the last four school years (1973 - 1974 - 1976 - 1977) [12].

Biological context of Schistosomiasis haematobia

• Muscle action potential amplitude recorded from abductor pollicis brevis in response to nerve stimulation was measured in 55 children during treatment of urinary schistosomiasis with metrifonate (3 doses at 2 weekly intervals) [13].

Anatomical context of Schistosomiasis haematobia

• Indirect assessment of eosinophiluria in urinary schistosomiasis using eosinophil cationic protein (ECP) and eosinophil protein X (EPX) [14].

Gene context of Schistosomiasis haematobia

• Detection of cellular and humoral markers (IL-2, IFN-gamma and IgE) in sera of patients with urinary schistosomiasis [15].
• The level of transferrin was significantly increased in non-pregnant subjects with urinary schistosomiasis compared with non-pregnant women without urinary schistosomiasis (p <0.01) suggesting the possibility of iron deficiency in these subjects [16].
• Alpha-2 macroglobulin was significantly elevated in pregnant subjects with urinary schistosomiasis compared with non-USS subjects, while the mean serum haptoglobin level was significantly higher in pregnant women without urinary schistosomiasis compared to pregnant subjects with urinary schistosomiasis [16].
• Heterologous systems were less reliable, particularly those using sera from urinary schistosomiasis patients [17].
• The concentration of ECP in vaginal fluid and the degree of immunohistochemical staining in histological sections were significantly higher in patients with FGS than in women with urinary schistosomiasis only [18].

Analytical, diagnostic and therapeutic context of Schistosomiasis haematobia

• After treatment with metrifonate (Bilarcil) the quantity of cryoglobulins and the number of children with cryoglobulins were significantly reduced to 12 (9.8%) when using macro-technique, and to 15 (12.3%) with micro-adaptation technique, thus suggesting a possible relationship of cryoglobulinaemia with urinary schistosomiasis [19].
• Use of metrifonate for selective population chemotherapy against urinary schistosomiasis in an endemic area at Mwanza, Tanzania [20].

References