Gene Review:
IL5 - interleukin 5
Homo sapiens
Synonyms:
B-cell differentiation factor I, EDF, Eosinophil differentiation factor, IL-5, Interleukin-5, ...
- T cells from eosinophilic patients produce interleukin-5 with interleukin-2 stimulation. Enokihara, H., Furusawa, S., Nakakubo, H., Kajitani, H., Nagashima, S., Saito, K., Shishido, H., Hitoshi, Y., Takatsu, K., Noma, T. Blood (1989)
- Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells. Yanagida, M., Fukamachi, H., Ohgami, K., Kuwaki, T., Ishii, H., Uzumaki, H., Amano, K., Tokiwa, T., Mitsui, H., Saito, H., Iikura, Y., Ishizaka, T., Nakahata, T. Blood (1995)
- Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60. Ingley, E., Young, I.G. Blood (1991)
- Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q). Le Beau, M.M., Lemons, R.S., Espinosa, R., Larson, R.A., Arai, N., Rowley, J.D. Blood (1989)
- Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Yamashiki, M., Nishimura, A., Suzuki, H., Sakaguchi, S., Kosaka, Y. Hepatology (1997)
- Cellular localization of interleukin-5 expression in rectal carcinoma with eosinophilia. Tajima, K., Yamakawa, M., Inaba, Y., Katagiri, T., Sasaki, H. Hum. Pathol. (1998)
- Test-retest reliability and criterion validity of the Chinese version of CBCL, TRF, and YSR. Leung, P.W., Kwong, S.L., Tang, C.P., Ho, T.P., Hung, S.F., Lee, C.C., Hong, S.L., Chiu, C.M., Liu, W.S. Journal of child psychology and psychiatry, and allied disciplines. (2006)
- Immunologic basis of antigen-induced airway hyperresponsiveness. Wills-Karp, M. Annu. Rev. Immunol. (1999)
- Identification of human Rap1: implications for telomere evolution. Li, B., Oestreich, S., de Lange, T. Cell (2000)
- A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Tavernier, J., Devos, R., Cornelis, S., Tuypens, T., Van der Heyden, J., Fiers, W., Plaetinck, G. Cell (1991)
- Creation of a biologically active interleukin-5 monomer. Dickason, R.R., Huston, D.P. Nature (1996)
- The effect of segmental bronchoprovocation with allergen on airway lymphocyte function. Kelly, E.A., Rodriguez, R.R., Busse, W.W., Jarjour, N.N. Am. J. Respir. Crit. Care Med. (1997)
- Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Truyen, E., Coteur, L., Dilissen, E., Overbergh, L., Dupont, L.J., Ceuppens, J.L., Bullens, D.M. Thorax (2006)
- Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils. Kishimoto, S., Shimadzu, W., Izumi, T., Shimizu, T., Fukuda, T., Makino, S., Sugiura, T., Waku, K. J. Immunol. (1996)
- Nasal biomarker profiles in acute and chronic rhinosinusitis. Riechelmann, H., Deutschle, T., Rozsasi, A., Keck, T., Polzehl, D., Bürner, H. Clin. Exp. Allergy (2005)
- IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. Mori, A., Suko, M., Nishizaki, Y., Kaminuma, O., Kobayashi, S., Matsuzaki, G., Yamamoto, K., Ito, K., Tsuruoka, N., Okudaira, H. Int. Immunol. (1995)
- Characterization of a palindromic enhancer element in the promoters of IL4, IL5, and IL13 cytokine genes. Codlin, S., Soh, C., Lee, T., Lavender, P. J. Allergy Clin. Immunol. (2003)
- A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression. Mordvinov, V.A., Peroni, S.E., De Boer, M.L., Kees, U.R., Sanderson, C.J. J. Immunol. Methods (1999)
- The frequency of interleukin-10- and interleukin-5-secreting CD4+ T cells correlates to tolerance of transplanted lung. Bianco, A.M., Solari, N., Miserere, S., Pellegrini, C., Vitulo, P., Pozzi, E., Fietta, A., Meloni, F. Transplant. Proc. (2005)
- Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects. Kay, A.B., Ying, S., Varney, V., Gaga, M., Durham, S.R., Moqbel, R., Wardlaw, A.J., Hamid, Q. J. Exp. Med. (1991)
- IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production. Ochi, H., De Jesus, N.H., Hsieh, F.H., Austen, K.F., Boyce, J.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Role of nuclear factor of activated T cells (NFAT) in the expression of interleukin-5 and other cytokines involved in the regulation of hemopoetic cells. De Boer, M.L., Mordvinov, V.A., Thomas, M.A., Sanderson, C.J. Int. J. Biochem. Cell Biol. (1999)
- Immune response to hepatitis B vaccine in asthmatic children. Masten, B., McWilliams, B., Lipscomb, M., Archibeque, T., Qualls, C., Kelly, H.W., Schuyler, M. Pediatr. Pulmonol. (2003)
- Covalent modification of the interleukin-5 receptor by isothiazolones leads to inhibition of the binding of interleukin-5. Devos, R., Guisez, Y., Plaetinck, G., Cornelis, S., Tavernier, J., van der Heyden, J., Foley, L.H., Scheffler, J.E. Eur. J. Biochem. (1994)
- Modulation of apoptosis with cytokines in B-cell chronic lymphocytic leukaemia. Mainou-Fowler, T., Prentice, A.G. Leuk. Lymphoma (1996)
- Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. Leung, D.Y., Martin, R.J., Szefler, S.J., Sher, E.R., Ying, S., Kay, A.B., Hamid, Q. J. Exp. Med. (1995)
- Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins. Johanson, K., Appelbaum, E., Doyle, M., Hensley, P., Zhao, B., Abdel-Meguid, S.S., Young, P., Cook, R., Carr, S., Matico, R. J. Biol. Chem. (1995)
- Distal regulatory elements play an important role in regulation of the human IL-5 gene. Urwin, D.L., Schwenger, G.T., Groth, D.M., Sanderson, C.J. Eur. J. Immunol. (2004)
- Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. Lopez, A.F., Vadas, M.A., Woodcock, J.M., Milton, S.E., Lewis, A., Elliott, M.J., Gillis, D., Ireland, R., Olwell, E., Park, L.S. J. Biol. Chem. (1991)
- Engagement of the CrkL adapter in interleukin-5 signaling in eosinophils. Du, J., Alsayed, Y.M., Xin, F., Ackerman, S.J., Platanias, L.C. J. Biol. Chem. (2000)
- Transcriptional regulation of the IL-5 gene in peripheral T cells of asthmatic patients. Ogawa, K., Kaminuma, O., Okudaira, H., Kikkawa, H., Ikezawa, K., Sakurai, N., Mori, A. Clin. Exp. Immunol. (2002)
- Recruitment of histone deacetylase 4 by transcription factors represses interleukin-5 transcription. Han, S., Lu, J., Zhang, Y., Cheng, C., Han, L., Wang, X., Li, L., Liu, C., Huang, B. Biochem. J. (2006)
- The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils. Pazdrak, K., Stafford, S., Alam, R. J. Immunol. (1995)
- Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells. Sato, N., Caux, C., Kitamura, T., Watanabe, Y., Arai, K., Banchereau, J., Miyajima, A. Blood (1993)
- Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer. van Haelst Pisani, C., Kovach, J.S., Kita, H., Leiferman, K.M., Gleich, G.J., Silver, J.E., Dennin, R., Abrams, J.S. Blood (1991)
- Constitutive production of IL-4 and IL-10 and stimulated production of IL-8 by normal peripheral blood eosinophils. Nakajima, H., Gleich, G.J., Kita, H. J. Immunol. (1996)
- Transmigration of eosinophils through basement membrane components in vitro: synergistic effects of platelet-activating factor and eosinophil-active cytokines. Okada, S., Kita, H., George, T.J., Gleich, G.J., Leiferman, K.M. Am. J. Respir. Cell Mol. Biol. (1997)
- Peripheral blood CD4 but not CD8 t-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Corrigan, C.J., Hamid, Q., North, J., Barkans, J., Moqbel, R., Durham, S., Gemou-Engesaeth, V., Kay, A.B. Am. J. Respir. Cell Mol. Biol. (1995)
- Eosinophilic inflammation: mechanisms regulating IL-5 transcription in human T lymphocytes. Wang, J., Young, I.G. Allergy (2007)
- Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. Mellor, E.A., Austen, K.F., Boyce, J.A. J. Exp. Med. (2002)
- Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Desreumaux, P., Brandt, E., Gambiez, L., Emilie, D., Geboes, K., Klein, O., Ectors, N., Cortot, A., Capron, M., Colombel, J.F. Gastroenterology (1997)
- Reassessing the Th2 cytokine basis of asthma. O'Byrne, P.M., Inman, M.D., Adelroth, E. Trends Pharmacol. Sci. (2004)
- In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients. Schaafsma, M.R., Falkenburg, J.H., Landegent, J.E., Duinkerken, N., Osanto, S., Ralph, P., Kaushansky, K., Wagemaker, G., Van Damme, J., Willemze, R. Blood (1991)
- Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Panitsas, F.P., Theodoropoulou, M., Kouraklis, A., Karakantza, M., Theodorou, G.L., Zoumbos, N.C., Maniatis, A., Mouzaki, A. Blood (2004)
- Effect of interleukin-5 exposure during in vitro eosinophilopiesis on MAC-1 adhesion molecule expression and function on cultured human eosinophils. Hamann, K.J., Neeley, S.P., Dowling, T.L., Grant, J.A., Leff, A.R. Blood (1996)