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Disease relevance of Poliomyelitis


High impact information on Poliomyelitis

  • Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis [6].
  • Landmark articles. Nov 13 and Dec 4, 1909, (JAMA 1909. The transmission of acute poliomyelitis to monkeys. By Simon Flexner, M.D., and Paul A. Lewis, M.D [7].
  • Vaccine-associated poliomyelitis in a household contact with Netherton's syndrome receiving long-term steroid therapy [8].
  • To examine replicating capacity of virus 2A-369 in the brain and liver of a mouse model for poliomyelitis, a new mouse model (MPVRTg25-61) that is transgenic for human PV receptor (hPVR; CD155) was generated in order to obtain a higher expression level of hPVR in the liver than those of hPVRTg mouse lines generated by us so far [9].
  • ALS and poliomyelitis [10].

Chemical compound and disease context of Poliomyelitis

  • Monoclonal antibody protection from age-dependent poliomyelitis: implications regarding the pathogenesis of lactate dehydrogenase-elevating virus [11].
  • However, the infectivity of non-enveloped viruses (e.g. poliomyelitis I) was not inhibited by H-7 [12].
  • Protracted diarrhea and lung infections were the main infectious complications; infection with bacillus Calmette-Guérin occurred in 10 of 28 vaccinated patients, but none of the six recipients of oral polio vaccine subsequently had poliomyelitis [13].
  • Furthermore, MRI can be used in the diagnosis of anterior horn infection and would play an important role in diagnosis of poliomyelitis [Kornreich L, Dagan O, Grunebaum M. MRI in acute poliomyelitis. Neuroradiology 1996;38(4):371-2] [14].
  • C58 mice which have been immunosuppressed by treatment with cyclophosphamide (200 mg/kg) one day prior to infection with the C strain of lactate dehydrogenase-elevating virus (LDV-C) develop poliomyelitis [15].

Biological context of Poliomyelitis


Anatomical context of Poliomyelitis


Gene context of Poliomyelitis

  • OBJECTIVE: We report a 54-year-old male with molecularly defined XLA who survived wild poliomyelitis in childhood before the diagnosis of XLA [23].
  • HLA-A, -B, and -D antigens in paralytic poliomyelitis [24].
  • In contrast, none of the children vaccinated against poliomyelitis had antibodies to the diabetes-associated epitope of tyrosine phosphatases IA-2/IAR [25].
  • Patients with late effects of poliomyelitis, i.e., PPS, are being seen at an ever increasing frequency by general physicians, neurologists, and orthopedists [26].
  • An outbreak of poliomyelitis with 20 cases occurred in Israel, Gaza, and the West Bank from October 1987 to October 1988 [27].

Analytical, diagnostic and therapeutic context of Poliomyelitis


  1. Shedding of sabin poliovirus Type 3 containing the nucleotide 472 uracil-to-cytosine point mutation after administration of oral poliovirus vaccine. Martinez, C.V., Old, M.O., Kwock, D.K., Khan, S.S., Garcia, J.J., Chan, C.S., Webster, R., Falkovitz-Halpern, M.S., Maldonado, Y.A. J. Infect. Dis. (2004) [Pubmed]
  2. Mouse strain-specific central nervous system lesions associated with lactate dehydrogenase-elevating virus infection. Stroop, W.G., Brinton, M.A. Lab. Invest. (1983) [Pubmed]
  3. Antibody persistence against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenzae type b (Hib) in 5-6-year-old children after primary vaccination and first booster with a pentavalent combined acellular pertussis vaccine: immunogenicity and tolerance of a tetravalent combined acellular pertussis vaccine given as a second booster. Mallet, E., Matisse, N., Mathieu, N., Langue, J., Boisnard, F., Soubeyrand, B. Vaccine (2004) [Pubmed]
  4. Structure and immunogenicity of experimental foot-and-mouth disease and poliomyelitis vaccines. Twomey, T., Newman, J., Burrage, T., Piatti, P., Lubroth, J., Brown, F. Vaccine (1995) [Pubmed]
  5. Use of the rocking bed in the treatment of neurogenic respiratory insufficiency. Chalmers, R.M., Howard, R.S., Wiles, C.M., Spencer, G.T. QJM : monthly journal of the Association of Physicians. (1994) [Pubmed]
  6. Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Ren, R.B., Costantini, F., Gorgacz, E.J., Lee, J.J., Racaniello, V.R. Cell (1990) [Pubmed]
  7. Landmark articles. Nov 13 and Dec 4, 1909, (JAMA 1909. The transmission of acute poliomyelitis to monkeys. By Simon Flexner, M.D., and Paul A. Lewis, M.D. Flexner, S., Lewis, P.A. JAMA (1983) [Pubmed]
  8. Vaccine-associated poliomyelitis in a household contact with Netherton's syndrome receiving long-term steroid therapy. Gross, T.P., Khurana, R.K., Higgins, T., Nkowane, B.S., Hirsch, R.L. Am. J. Med. (1987) [Pubmed]
  9. Tissue-specific replicating capacity of a chimeric poliovirus that carries the internal ribosome entry site of hepatitis C virus in a new mouse model transgenic for the human poliovirus receptor. Yanagiya, A., Ohka, S., Hashida, N., Okamura, M., Taya, C., Kamoshita, N., Iwasaki, K., Sasaki, Y., Yonekawa, H., Nomoto, A. J. Virol. (2003) [Pubmed]
  10. ALS and poliomyelitis. Moriwaka, F., Tashiro, K., Okumura, H., Yamada, T. Neurology (1991) [Pubmed]
  11. Monoclonal antibody protection from age-dependent poliomyelitis: implications regarding the pathogenesis of lactate dehydrogenase-elevating virus. Harty, J.T., Plagemann, P.G. J. Virol. (1990) [Pubmed]
  12. Effects of protein kinase C inhibitors on viral entry and infectivity. Constantinescu, S.N., Cernescu, C.D., Popescu, L.M. FEBS Lett. (1991) [Pubmed]
  13. Severe combined immunodeficiency: a retrospective single-center study of clinical presentation and outcome in 117 patients. Stephan, J.L., Vlekova, V., Le Deist, F., Blanche, S., Donadieu, J., De Saint-Basile, G., Durandy, A., Griscelli, C., Fischer, A. J. Pediatr. (1993) [Pubmed]
  14. Clinical presentations of acute paralytic poliomyelitis. Arya, S.C., Agarwal, N. Vaccine (2006) [Pubmed]
  15. Detection of viral-specific nucleic acid and intracellular virions in ventral horn neurons of lactate dehydrogenase-elevating virus infected C58 mice. Brinton, M.A., Gavin, E.I., Weibel, J. Microb. Pathog. (1986) [Pubmed]
  16. Role of poliovirus receptors in the spread of the infection. Freistadt, M.S., Stoltz, D.A., Eberle, K.E. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  17. Dead wrong--estrogens, osteoporosis cancer and public policy. Gordan, G.S. Journal of medicine. (1980) [Pubmed]
  18. Cell mediated immunity to polio antigens in the early stage of acute poliomyelitis. Livni, R., Lasch, E.E., Englander, T., El Massri, M., Danon, Y.L. Allergologia et immunopathologia. (1984) [Pubmed]
  19. Comparison of neuropathogenicity of poliovirus in two transgenic mouse strains expressing human poliovirus receptor with different distribution patterns. Ida-Hosonuma, M., Iwasaki, T., Taya, C., Sato, Y., Li, J., Nagata, N., Yonekawa, H., Koike, S. J. Gen. Virol. (2002) [Pubmed]
  20. Motor neuron disease and past poliomyelitis. Geographic study in Hokkaido, the northern-most island of Japan. ALS Study Group. Moriwaka, F., Okumura, H., Tashiro, K., Hamada, T., Matsumoto, A., Matsumoto, H., Itoh, N., Shindo, R., Takahata, N. J. Neurol. (1993) [Pubmed]
  21. Polio antibodies and HLA antigens in amyotrophic lateral sclerosis. Jokelainen, M., Tiilikainen, A., Lapinleimu, K. Tissue Antigens (1977) [Pubmed]
  22. Immunohistochemical study on synaptophysin in the spinal cord of chronic anterior poliomyelitis. Ikemoto, A., Hirano, A. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  23. Survival of wild polio by a patient with XLA. Sarpong, S., Skolnick, H.S., Ochs, H.D., Futatani, T., Winkelstein, J.A. Ann. Allergy Asthma Immunol. (2002) [Pubmed]
  24. HLA-A, -B, and -D antigens in paralytic poliomyelitis. Zander, H., Grosse-Wilde, H., Kuntz, B., Scholz, S., Albert, E.D. Tissue Antigens (1979) [Pubmed]
  25. Enterovirus infection may induce humoral immune response reacting with islet cell autoantigens in humans. Härkönen, T., Paananen, A., Lankinen, H., Hovi, T., Vaarala, O., Roivainen, M. J. Med. Virol. (2003) [Pubmed]
  26. Neurological manifestations of the post-polio syndrome. Jubelt, B., Cashman, N.R. Critical reviews in neurobiology. (1987) [Pubmed]
  27. Resolution of the pathways of poliovirus type 1 transmission during an outbreak. Shulman, L.M., Handsher, R., Yang, C.F., Yang, S.J., Manor, J., Vonsover, A., Grossman, Z., Pallansch, M., Mendelson, E., Kew, O.M. J. Clin. Microbiol. (2000) [Pubmed]
  28. Franklin D. Roosevelt: diagnosis, clinical course, and rehabilitation from poliomyelitis. Ditunno, J.F., Herbison, G.J. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. (2002) [Pubmed]
  29. A poliovirus type-specific IgM antibody-capture enzyme-linked immunosorbent assay for the rapid diagnosis of poliomyelitis. Nibbeling, R., Reimerink, J.H., Agboatwala, M., Naquib, T., Ras, A., Poelstra, P., van der Avoort, H.G., van Loon, A.M. Clinical and diagnostic virology. (1994) [Pubmed]
  30. Management of the neuromuscular foot deformities with the Ilizarov method. Kucukkaya, M., Kabukcuoglu, Y., Kuzgun, U. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (2002) [Pubmed]
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