Disease relevance of Poliomyelitis

• A uracil-to-cytosine point mutation at nucleotide (nt) 472 of Sabin oral poliovirus vaccine (OPV) type 3 is found in conjunction with vaccine-associated paralytic poliomyelitis (VAPP) [1].
• Lactate dehydrogenase-elevating virus-infected C57L, C57BL/6, and RF mice did not develop poliomyelitis; however, C57L and C57BL/6 mice displayed a low incidence of mild encephalomyelitis [2].
• RESULTS: Seroprotective antibody levels against diphtheria, tetanus, types 1-3 poliomyelitis and PRP were maintained 4-5 years after primary-vaccination and first booster with Pentavac [3].
• The physico-chemical properties and immunogenicity of experimental vaccines against foot-and-mouth disease (FMD) and poliomyelitis, prepared by treatment of the viruses with N-acetylethyleneimine (AEI), formaldehyde or neutral red, have been studied [4].
• Diagnoses included previous poliomyelitis (30), muscular dystrophy (12), motor neurone disease (4), adult-onset acid maltase deficiency (4) and a miscellaneous group (3) [5].

High impact information on Poliomyelitis

• Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis [6].
• Landmark articles. Nov 13 and Dec 4, 1909, (JAMA 1909. The transmission of acute poliomyelitis to monkeys. By Simon Flexner, M.D., and Paul A. Lewis, M.D [7].
• Vaccine-associated poliomyelitis in a household contact with Netherton's syndrome receiving long-term steroid therapy [8].
• To examine replicating capacity of virus 2A-369 in the brain and liver of a mouse model for poliomyelitis, a new mouse model (MPVRTg25-61) that is transgenic for human PV receptor (hPVR; CD155) was generated in order to obtain a higher expression level of hPVR in the liver than those of hPVRTg mouse lines generated by us so far [9].
• ALS and poliomyelitis [10].

Chemical compound and disease context of Poliomyelitis

• Monoclonal antibody protection from age-dependent poliomyelitis: implications regarding the pathogenesis of lactate dehydrogenase-elevating virus [11].
• However, the infectivity of non-enveloped viruses (e.g. poliomyelitis I) was not inhibited by H-7 [12].
• Protracted diarrhea and lung infections were the main infectious complications; infection with bacillus Calmette-Guérin occurred in 10 of 28 vaccinated patients, but none of the six recipients of oral polio vaccine subsequently had poliomyelitis [13].
• Furthermore, MRI can be used in the diagnosis of anterior horn infection and would play an important role in diagnosis of poliomyelitis [Kornreich L, Dagan O, Grunebaum M. MRI in acute poliomyelitis. Neuroradiology 1996;38(4):371-2] [14].
• C58 mice which have been immunosuppressed by treatment with cyclophosphamide (200 mg/kg) one day prior to infection with the C strain of lactate dehydrogenase-elevating virus (LDV-C) develop poliomyelitis [15].

Biological context of Poliomyelitis

• Although the poliovirus receptor (PVR) has been cloned, lack of knowledge of its precise tissue distribution makes assessment of its role in mediating poliomyelitis difficult [16].
• More recent examples are the long delays in the use of propranolol, cimetidine, bromcryptine, pulmonary surgery, antihypertensive therapy, poliomyelitis vaccination, penicillin and cardiac surgery [17].
• Specific cell-mediated immunity to polio antigens in 22 children suffering from acute paralytic poliomyelitis was investigated by the macrophage migration inhibition factor (MIF) technique [18].

Anatomical context of Poliomyelitis

• In the former, the expression of PVR in neurons in the central nervous system (CNS) conferred susceptibility to poliovirus, and a paralytic disease that resembled the human poliomyelitis occurred [19].
• Motor neuron disease and past poliomyelitis. Geographic study in Hokkaido, the northern-most island of Japan. ALS Study Group [20].
• Its possible association with poliomyelitis was studied by measuring neutralizing antibodies against polio virus types 1, 2 and 3 in the sera and cerebrospinal fluids of 11 ALS-patients, but antibody titers did not markedly differ from those of the controls [21].
• Immunohistochemical study on synaptophysin in the spinal cord of chronic anterior poliomyelitis [22].

Gene context of Poliomyelitis

• OBJECTIVE: We report a 54-year-old male with molecularly defined XLA who survived wild poliomyelitis in childhood before the diagnosis of XLA [23].
• HLA-A, -B, and -D antigens in paralytic poliomyelitis [24].
• In contrast, none of the children vaccinated against poliomyelitis had antibodies to the diabetes-associated epitope of tyrosine phosphatases IA-2/IAR [25].
• Patients with late effects of poliomyelitis, i.e., PPS, are being seen at an ever increasing frequency by general physicians, neurologists, and orthopedists [26].
• An outbreak of poliomyelitis with 20 cases occurred in Israel, Gaza, and the West Bank from October 1987 to October 1988 [27].

Analytical, diagnostic and therapeutic context of Poliomyelitis

• Franklin D. Roosevelt: diagnosis, clinical course, and rehabilitation from poliomyelitis [28].
• CONCLUSION: The use of the poliovirus type-specific IgM antibody-capture ELISA allows rapid diagnosis of poliomyelitis within 24 h after obtaining serum or a CSF specimen [29].
• Nine feet of eight patients with neurologic foot deformities caused from poliomyelitis, Charcot-Marie-Tooth disease, and traumatic nerve injury were treated with V-osteotomy and the Ilizarov method [30].

References