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MeSH Review


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Disease relevance of Deglutition


High impact information on Deglutition

  • Seizures associated with deglutition are rare, and previously reported cases of so-called eating epilepsy have not identified specific electrophysiological or anatomical foci [4].
  • Forty-nine Mns showed a chloride-dependent hyperpolarization with a variable duration at the onset of swallowing, followed by a depolarization that could take place during either the buccopharyngeal (HD1-Mns) or the esophageal (HD2- and HD3-Mns) stage of deglutition [5].
  • The high concentrations of 5HT1A receptors in the central and intermediate subnuclei suggest a role for these receptors in medullary reflex pathways subserving deglutition [6].
  • Oropharyngeal deglutition in stable COPD [7].
  • Effects of atropine on the central mechanism of deglutition in anesthetized sheep [8].

Anatomical context of Deglutition

  • At the onset of oral deglutition, when placed between the dorsum of the tongue and the groove of the hard palate, the bolus has an ellipsoidal shape, thus permitting sagittal, axial, and coronal measurements [9].
  • Subjects with poor tubal function have an increased incidence of abnormal deglutition combined with tongue-thrust, teeth-apart swallowing, lack of sealing off the anterior oral cavity and contraction of the circumoral musculature [10].

Associations of Deglutition with chemical compounds

  • These data demonstrate that deglutition can be triggered by activating either NMDA or non-NMDA receptors localized within the NTS, and therefore suggest that both receptor subtypes may be involved in swallowing elicited under physiological conditions [11].
  • GABA receptor-mediated inhibition of reflex deglutition in the cat [12].
  • Animals perfused with either an acidified pepsin solution for 45 min or with 100 mM hydrochloric acid for 45 min on each of three consecutive days exhibited a significantly impaired deglutition reflex in comparison to baseline [13].
  • Microcapsules of theophylline, administered as a suspension in water, proved to be a suitable dosage form for a clientele with impaired or difficult deglutition [14].
  • It is our conclusion that preoperative chemotherapy using cisplatin, vincristine, and bleomycin can improve the compromised airway and deglutition without producing deleterious effects relative to surgical complications [15].

Gene context of Deglutition

  • Dysphagia after pharyngolaryngeal cancer surgery. Part I: Pathophysiology of postsurgical deglutition [16].
  • The potential risk of aspiration and malnutrition and the high efficacy of swallowing rehabilitation suggests that all MS patients should have a careful evaluation of deglutition functionality, especially those with brainstem impairment and a high grade of disability level [17].
  • Relationship between tubal function, craniofacial morphology and disorder of deglutition [10].
  • Determination of the response of this high pressure zone to cholinergic stimulation, a protein meal and deglutition before and after Belsey Mark IV fundoplasty in seven patients with intractable reflux indicates the latter [18].
  • Towards the end of the sequence, triturated material was moved to the midline (aggregation shift) for bolus formation and deglutition [19].


  1. The effect of head and neck positions on oropharyngeal swallowing: a clinical and electrophysiologic study. Ertekin, C., Keskin, A., Kiylioglu, N., Kirazli, Y., On, A.Y., Tarlaci, S., Aydoğdu, I. Archives of physical medicine and rehabilitation. (2001) [Pubmed]
  2. Myasthenia in patients with dermatomyositis: clinical, electrophysiological and ultrastructural studies. Vasilescu, C., Bucur, G., Petrovici, A., Florescu, A. J. Neurol. Sci. (1978) [Pubmed]
  3. Dysphagia in Huntington's disease: a 16-year retrospective. Kagel, M.C., Leopold, N.A. Dysphagia. (1992) [Pubmed]
  4. Eating epilepsy associated with a deep forebrain glioma. Robertson, W.C., Fariello, R.G. Ann. Neurol. (1979) [Pubmed]
  5. Intracellular activity of motoneurons of the rostral nucleus ambiguus during swallowing in sheep. Zoungrana, O.R., Amri, M., Car, A., Roman, C. J. Neurophysiol. (1997) [Pubmed]
  6. Organization of serotonin 1A and 1B receptors in the nucleus of the solitary tract. Manaker, S., Verderame, H.M. J. Comp. Neurol. (1990) [Pubmed]
  7. Oropharyngeal deglutition in stable COPD. Mokhlesi, B., Logemann, J.A., Rademaker, A.W., Stangl, C.A., Corbridge, T.C. Chest (2002) [Pubmed]
  8. Effects of atropine on the central mechanism of deglutition in anesthetized sheep. Car, A., Roman, C., Zoungrana, O.R. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2002) [Pubmed]
  9. Sonographic evaluation of physiologic bolus volume in oral swallowing. Fanucci, A., Cerro, P., Fanucci, E. American journal of physiologic imaging. (1992) [Pubmed]
  10. Relationship between tubal function, craniofacial morphology and disorder of deglutition. Jonas, I., Mann, W., Münker, G., Junker, W., Schumann, K. Archives of oto-rhino-laryngology. (1978) [Pubmed]
  11. Evidence that activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptors within the nucleus tractus solitarii triggers swallowing. Kessler, J.P., Jean, A. Eur. J. Pharmacol. (1991) [Pubmed]
  12. GABA receptor-mediated inhibition of reflex deglutition in the cat. Hockman, C.H., Weerasuriya, A., Bieger, D. Dysphagia. (1996) [Pubmed]
  13. Impairment of deglutition reflex by acid-induced esophageal mucosal injury. White, R.J., Morris, G.P., Paterson, W.G. Dig. Dis. Sci. (2001) [Pubmed]
  14. Pharmacokinetic characteristics of a new liquid sustained-release formulation of theophylline designed for the elderly and children: microcaps as sachet. Fuchs, W.S., Weiss, G., Von Nieciecki, A., Laicher, A., Gay, S., Pabst, G., Müller, M. International journal of clinical pharmacology and therapeutics. (1996) [Pubmed]
  15. Preoperative adjuvant chemotherapy for advanced head and neck cancer: a surgical evaluation. Loré, J.M., Bonilla, J.A., Spaulding, M., Lee, K.Y., Kaufman, S., Sundquist, N., Smeeding, D. Journal of surgical oncology. Supplement. (1989) [Pubmed]
  16. Dysphagia after pharyngolaryngeal cancer surgery. Part I: Pathophysiology of postsurgical deglutition. Walther, E.K. Dysphagia. (1995) [Pubmed]
  17. Dysphagia in multiple sclerosis - prevalence and prognostic factors. Calcagno, P., Ruoppolo, G., Grasso, M.G., De Vincentiis, M., Paolucci, S. Acta neurologica Scandinavica. (2002) [Pubmed]
  18. Evaluation of the effect of fundoplication on the incompetent lower esophageal sphincter. Higgs, R.H., Castell, D.O., Farrell, R.L. Surgery, gynecology & obstetrics. (1975) [Pubmed]
  19. A postero-anterior videofluorographic study of the intra-oral management of food in man. Mioche, L., Hiiemae, K.M., Palmer, J.B. Arch. Oral Biol. (2002) [Pubmed]
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