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Chemical Compound Review

Iodo-Dox     (7S,9R)-7-[(2S,4S,5S,6S)-4- amino-5-iodo-6...

Synonyms: I-DOX, SureCN62735, CHEBI:47897, FCE-21954, KST-1A8761, ...
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Disease relevance of Iododoxorubicin


High impact information on Iododoxorubicin


Chemical compound and disease context of Iododoxorubicin


Biological context of Iododoxorubicin


Anatomical context of Iododoxorubicin


Associations of Iododoxorubicin with other chemical compounds


Gene context of Iododoxorubicin


Analytical, diagnostic and therapeutic context of Iododoxorubicin


  1. Pharmacology and clinical toxicity of 4'-iodo-4'-deoxydoxorubicin: an example of successful application of pharmacokinetics to dose escalation in phase I trials. Gianni, L., Viganò, L., Surbone, A., Ballinari, D., Casali, P., Tarella, C., Collins, J.M., Bonadonna, G. J. Natl. Cancer Inst. (1990) [Pubmed]
  2. New drug therapy of amyloidoses: resorption of AL-type deposits with 4'-iodo-4'-deoxydoxorubicin. Gianni, L., Bellotti, V., Gianni, A.M., Merlini, G. Blood (1995) [Pubmed]
  3. Adoptive transfer of lymphokine-activated killer cells loaded with 4'-deoxy-4'-iododoxorubicin: therapeutic effect in mice bearing lung metastases. Mandruzzato, S., Rosato, A., Bronte, V., Zanovello, P., Amboldi, N., Ballinari, D., Collavo, D. Cancer Res. (1994) [Pubmed]
  4. Characterization of tumor cell resistance to 4'-deoxy-4'-iododoxorubicin developed in Ehrlich ascites cells in vivo. Friche, E., Danks, M.K., Beck, W.T. Cancer Res. (1992) [Pubmed]
  5. Chemical and biological characterization of 4'-iodo-4'-deoxydoxorubicin. Barbieri, B., Giuliani, F.C., Bordoni, T., Casazza, A.M., Geroni, C., Bellini, O., Suarato, A., Gioia, B., Penco, S., Arcamone, F. Cancer Res. (1987) [Pubmed]
  6. Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis. Merlini, G., Ascari, E., Amboldi, N., Bellotti, V., Arbustini, E., Perfetti, V., Ferrari, M., Zorzoli, I., Marinone, M.G., Garini, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Pharmacokinetics and metabolism of 4'-iodo-4'-deoxy-doxorubicin in humans. Robert, J., Armand, J.P., Huet, S., Klink-Alakl, M., Recondo, G., Hurteloup, P. J. Clin. Oncol. (1992) [Pubmed]
  8. Absolute and relative activities of 4' -iodo-4'-deoxydoxorubicin against human colo-rectal tumors, as evaluated by a short-term in vitro assay. Villa, R., Zaffaroni, N., Giuliani, F.C., Colella, G., Sanfilippo, O., Silvestrini, R. Anticancer Res. (1990) [Pubmed]
  9. Molecular structure of the halogenated anti-cancer drug iododoxorubicin complexed with d(TGTACA) and d(CGATCG). Berger, I., Su, L., Spitzner, J.R., Kang, C., Burke, T.G., Rich, A. Nucleic Acids Res. (1995) [Pubmed]
  10. Activity and toxicity of 4'-iodo-4'-deoxydoxorubicin in patients with advanced breast cancer. Gianni, L., Capri, G., Greco, M., Villani, F., Brambilla, C., Luini, A., Crippa, F., Bonadonna, G. Ann. Oncol. (1991) [Pubmed]
  11. Effects of lipophilicity and protein binding on the hepatocellular uptake and hepatic disposition of two anthracyclines, doxorubicin and iododoxorubicin. Rivory, L.P., Avent, K.M., Pond, S.M. Cancer Chemother. Pharmacol. (1996) [Pubmed]
  12. Superoxide anion production by doxorubicin analogs in heart sarcosomes and by mitochondrial NADH dehydrogenase. Gervasi, P.G., Agrillo, M.R., Lippi, A., Bernardini, N., Danesi, R., Del Tacca, M. Res. Commun. Chem. Pathol. Pharmacol. (1990) [Pubmed]
  13. Cellular uptake, cytotoxicity, and transport kinetics of anthracyclines in human sensitive and multidrug-resistant K562 cells. Praet, M., Stryckmans, P., Ruysschaert, J.M. Biochem. Pharmacol. (1996) [Pubmed]
  14. Current therapeutic strategies in cardiac amyloidosis. Parikh, S., de Lemos, J.A. Current treatment options in cardiovascular medicine. (2005) [Pubmed]
  15. Kinetics of anthracycline accumulation in multidrug-resistant tumor cells: relationship to drug lipophilicity and serum albumin binding. Demant, E.J., Friche, E. Biochem. Pharmacol. (1998) [Pubmed]
  16. Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. Almeida, M.R., Gales, L., Damas, A.M., Cardoso, I., Saraiva, M.J. Current drug targets. CNS and neurological disorders. (2005) [Pubmed]
  17. Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization. Findeis, M.A. Biochim. Biophys. Acta (2000) [Pubmed]
  18. 4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. Palha, J.A., Ballinari, D., Amboldi, N., Cardoso, I., Fernandes, R., Bellotti, V., Merlini, G., Saraiva, M.J. Am. J. Pathol. (2000) [Pubmed]
  19. Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis. Sonveaux, N., Vigano, C., Shapiro, A.B., Ling, V., Ruysschaert, J.M. J. Biol. Chem. (1999) [Pubmed]
  20. Phase II studies of 4'-iodo-4'-deoxydoxorubicin in advanced non-small cell lung, colon and breast cancers. Sessa, C., Calabresi, F., Cavalli, F., Cerny, T., Liati, P., Skovsgaard, T., Sorio, R., Kaye, S.B. Ann. Oncol. (1991) [Pubmed]
  21. 4'-iodo-4'-deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters. Cardoso, I., Merlini, G., Saraiva, M.J. FASEB J. (2003) [Pubmed]
  22. Intracellular mapping of 4'-deoxy-4'-iododoxorubicin in sensitive and multidrug resistant cells by electron spectroscopic imaging. Diociaiuti, M., Calcabrini, A., Meschini, S., Arancia, G. Micron (1997) [Pubmed]
  23. Studies of iododoxorubicin by HPLC. Mariani, R., Farina, M., Sfreddo, W. Journal of pharmaceutical and biomedical analysis. (1989) [Pubmed]
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