Chemical Compound Review:
flufenamic acid 2-[[3-(trifluoromethyl) phenyl]amino]benzoi...
Synonyms:
Flufacid, Fullsafe, Plostene, Ristogen, Achless, ...
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- Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Hill, K., Benham, C.D., McNulty, S., Randall, A.D. Neuropharmacology (2004)
- Penetration and enrichment of flufenamic acid in calf skin from patients with stasis dermatitis. Bahmer, F.A., Loth, H., Wild, T. Acta Derm. Venereol. (1990)
- The effect of flufenamic acid on gastrointestinal myoelectrical activity and transit time in dogs. Farrugia, G., Nitecki, S., Harty, G.J., Camilleri, M., Szurszewski, J.H. Gut (1998)
- Reduction of menstrual blood-loss by prostaglandin-synthetase inhibitors. Anderson, A.B., Haynes, P.J., Guillebaud, J., Turnbull, A.C. Lancet (1976)
- Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Peterson, S.A., Klabunde, T., Lashuel, H.A., Purkey, H., Sacchettini, J.C., Kelly, J.W. Proc. Natl. Acad. Sci. U.S.A. (1998)
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- Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents. Miles, L.A., Burnier, J.P., Verlander, M.S., Goodman, M., Kleiss, A.J., Griffin, J.H. Blood (1981)
- Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Lovering, A.L., Ride, J.P., Bunce, C.M., Desmond, J.C., Cummings, S.M., White, S.A. Cancer Res. (2004)
- A comparative study of naproxen gel and flufenamic acid gel in the treatment of soft tissue injuries. Seligra, A., Inglés, F. Current medical research and opinion. (1990)
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- Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. Corasaniti, M.T., Melino, G., Navarra, M., Garaci, E., Finazzi-Agrò, A., Nisticò, G. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. (1995)
- Effect of flufenamic acid on uterine contractions and plasma levels of 15-keto-13,14-dihydroprostaglandin F2alpha in preterm labor. Schwartz, A., Brook, I., Insler, V., Kohen, F., Zor, U., Lindner, H.R. Gynecol. Obstet. Invest. (1978)
- Antimonial-induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes. Sudhandiran, G., Shaha, C. J. Biol. Chem. (2003)
- Overexpression of a 123-kDa anion transport inhibitor binding protein and two cytoskeleton proteins in Drosophila Kc cell variants resistant to disulfonic stilbenes. Sherwood, A.C., John-Alder, K., Biessmann, H., Sanders, M.M. J. Biol. Chem. (1989)
- Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes. Tahara, S., Fukuda, K., Kodama, H., Kato, T., Miyoshi, S., Ogawa, S. J. Am. Coll. Cardiol. (2001)
- Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid. Zwart, R., Oortgiesen, M., Vijverberg, H.P. J. Neurosci. (1995)
- Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. Stout, C.E., Costantin, J.L., Naus, C.C., Charles, A.C. J. Biol. Chem. (2002)
- Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids. Lyall, V., Pasley, H., Phan, T.H., Mummalaneni, S., Heck, G.L., Vinnikova, A.K., DeSimone, J.A. J. Gen. Physiol. (2006)
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- Transient receptor potential-like channels mediate metabotropic glutamate receptor EPSCs in rat dopamine neurones. Bengtson, C.P., Tozzi, A., Bernardi, G., Mercuri, N.B. J. Physiol. (Lond.) (2004)
- Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells. Braet, K., Aspeslagh, S., Vandamme, W., Willecke, K., Martin, P.E., Evans, W.H., Leybaert, L. J. Cell. Physiol. (2003)
- An ex vivo method for evaluating prostaglandin synthetase activity in cortical slices of mouse brain. Shohami, E., Gross, J. J. Neurochem. (1985)
- Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. Paik, J.H., Ju, J.H., Lee, J.Y., Boudreau, M.D., Hwang, D.H. J. Biol. Chem. (2000)
- Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. Steckelbroeck, S., Oyesanmi, B., Jin, Y., Lee, S.H., Kloosterboer, H.J., Penning, T.M. J. Pharmacol. Exp. Ther. (2006)
- Androgen receptors in prostate cancer. Culig, Z., Klocker, H., Bartsch, G., Hobisch, A. Endocr. Relat. Cancer (2002)
- Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Pocock, T.M., Foster, R.R., Bates, D.O. Am. J. Physiol. Heart Circ. Physiol. (2004)
- Identification of the binding site for a low-molecular-weight inhibitor of plasminogen activator inhibitor type 1 by site-directed mutagenesis. Björquist, P., Ehnebom, J., Inghardt, T., Hansson, L., Lindberg, M., Linschoten, M., Strömqvist, M., Deinum, J. Biochemistry (1998)
- Flufenamic acid in treatment of primary spasmodic dysmenorrhoea. A double-blind crossover study. Kapadia, L., Elder, M.G. Lancet (1978)
- Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. McCarty, N.A., McDonough, S., Cohen, B.N., Riordan, J.R., Davidson, N., Lester, H.A. J. Gen. Physiol. (1993)
- Quantitative determination of flufenamic acid and its major metabolites in plasma by high-performance liquid chromatography. Kubo, O., Nishide, K., Kiriyama, N. J. Chromatogr. (1979)
- Interrelation of permeation and penetration parameters obtained from in vitro experiments with human skin and skin equivalents. Wagner, H., Kostka, K.H., Lehr, C.M., Schaefer, U.F. Journal of controlled release : official journal of the Controlled Release Society. (2001)