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Chemical Compound Review

flufenamic acid     2-[[3-(trifluoromethyl) phenyl]amino]benzoi...

Synonyms: Flufacid, Fullsafe, Plostene, Ristogen, Achless, ...
 
 
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Disease relevance of flufenamic acid

 

Psychiatry related information on flufenamic acid

 

High impact information on flufenamic acid

 

Chemical compound and disease context of flufenamic acid

 

Biological context of flufenamic acid

 

Anatomical context of flufenamic acid

  • Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid [19].
  • Astrocytes showed low Ca(2+)-activated whole-cell currents consistent with connexin hemichannel currents that were inhibited by the connexin channel inhibitor flufenamic acid (FFA) [20].
  • RESULTS: Flufenamic acid (600 mg, intravenously) induced intense spike activity in the small intestine [6].
  • FFA reduced gap junction channel currents in a reversible and concentration-dependent manner [2].
  • We conclude that a decrease in pHi induces TRC shrinkage through its effect on the actin cytoskeleton and activates a flufenamic acid-sensitive basolateral cation conductance that is involved in eliciting the phasic part of the CT response to acidic stimuli [21].
 

Associations of flufenamic acid with other chemical compounds

 

Gene context of flufenamic acid

  • Furthermore, the results suggest that the anti-inflammatory effects of flufenamic acid and some other NSAIDs are due to their inhibitory action on the mitogen-induced expression of COX-2 and downstream markers of inflammation in addition to their inhibitory effect on COX enzyme activity [26].
  • 3beta-HSD activity was inhibited by both 5beta-cholanic acid-3alpha,7alpha-diol and flufenamic acid, implicating a role for AKR1C2 and AKR1C1 [27].
  • Inhibition of AR expression could be achieved by potential chemopreventive agents flufenamic acid, resveratrol, quercetin, polyunsaturated fatty acids and interleukin-1beta, and by the application of AR antisense oligonucleotides [28].
  • Flufenamic acid, which has been shown to enhance activity of TRPC-6 but inhibit TRPC-3 and -7, enhanced the VEGF-mediated increase in L(p) in approximately half of the vessels tested but inhibited the response in the other half of the vessels [29].
  • A novel low-molecular-weight inhibitor, AR-H029953XX, was developed from a known fibrinolytic compound, flufenamic acid, which prevented complex formation of human plasminogen activator inhibitor type 1 (PAI-1) with tissue plasminogen activator (tPA) by inhibition of PAI-1 [30].
 

Analytical, diagnostic and therapeutic context of flufenamic acid

References

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  20. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. Stout, C.E., Costantin, J.L., Naus, C.C., Charles, A.C. J. Biol. Chem. (2002) [Pubmed]
  21. Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids. Lyall, V., Pasley, H., Phan, T.H., Mummalaneni, S., Heck, G.L., Vinnikova, A.K., DeSimone, J.A. J. Gen. Physiol. (2006) [Pubmed]
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  27. Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. Steckelbroeck, S., Oyesanmi, B., Jin, Y., Lee, S.H., Kloosterboer, H.J., Penning, T.M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
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