The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

flufenamic acid     2-[[3-(trifluoromethyl) phenyl]amino]benzoi...

Synonyms: Flufacid, Fullsafe, Plostene, Ristogen, Achless, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of flufenamic acid


Psychiatry related information on flufenamic acid


High impact information on flufenamic acid


Chemical compound and disease context of flufenamic acid


Biological context of flufenamic acid


Anatomical context of flufenamic acid

  • Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid [19].
  • Astrocytes showed low Ca(2+)-activated whole-cell currents consistent with connexin hemichannel currents that were inhibited by the connexin channel inhibitor flufenamic acid (FFA) [20].
  • RESULTS: Flufenamic acid (600 mg, intravenously) induced intense spike activity in the small intestine [6].
  • FFA reduced gap junction channel currents in a reversible and concentration-dependent manner [2].
  • We conclude that a decrease in pHi induces TRC shrinkage through its effect on the actin cytoskeleton and activates a flufenamic acid-sensitive basolateral cation conductance that is involved in eliciting the phasic part of the CT response to acidic stimuli [21].

Associations of flufenamic acid with other chemical compounds


Gene context of flufenamic acid

  • Furthermore, the results suggest that the anti-inflammatory effects of flufenamic acid and some other NSAIDs are due to their inhibitory action on the mitogen-induced expression of COX-2 and downstream markers of inflammation in addition to their inhibitory effect on COX enzyme activity [26].
  • 3beta-HSD activity was inhibited by both 5beta-cholanic acid-3alpha,7alpha-diol and flufenamic acid, implicating a role for AKR1C2 and AKR1C1 [27].
  • Inhibition of AR expression could be achieved by potential chemopreventive agents flufenamic acid, resveratrol, quercetin, polyunsaturated fatty acids and interleukin-1beta, and by the application of AR antisense oligonucleotides [28].
  • Flufenamic acid, which has been shown to enhance activity of TRPC-6 but inhibit TRPC-3 and -7, enhanced the VEGF-mediated increase in L(p) in approximately half of the vessels tested but inhibited the response in the other half of the vessels [29].
  • A novel low-molecular-weight inhibitor, AR-H029953XX, was developed from a known fibrinolytic compound, flufenamic acid, which prevented complex formation of human plasminogen activator inhibitor type 1 (PAI-1) with tissue plasminogen activator (tPA) by inhibition of PAI-1 [30].

Analytical, diagnostic and therapeutic context of flufenamic acid


  1. Migraine attacks. Alleviation by an inhibitor of prostaglandin synthesis and action. Vardi, Y., Rabey, I.M., Streifler, M., Schwartz, A., Lindner, H.R., Zor, U. Neurology (1976) [Pubmed]
  2. Closure of gap junction channels by arylaminobenzoates. Srinivas, M., Spray, D.C. Mol. Pharmacol. (2003) [Pubmed]
  3. 1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities. Boschelli, D.H., Connor, D.T., Bornemeier, D.A., Dyer, R.D., Kennedy, J.A., Kuipers, P.J., Okonkwo, G.C., Schrier, D.J., Wright, C.D. J. Med. Chem. (1993) [Pubmed]
  4. Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Hill, K., Benham, C.D., McNulty, S., Randall, A.D. Neuropharmacology (2004) [Pubmed]
  5. Penetration and enrichment of flufenamic acid in calf skin from patients with stasis dermatitis. Bahmer, F.A., Loth, H., Wild, T. Acta Derm. Venereol. (1990) [Pubmed]
  6. The effect of flufenamic acid on gastrointestinal myoelectrical activity and transit time in dogs. Farrugia, G., Nitecki, S., Harty, G.J., Camilleri, M., Szurszewski, J.H. Gut (1998) [Pubmed]
  7. Reduction of menstrual blood-loss by prostaglandin-synthetase inhibitors. Anderson, A.B., Haynes, P.J., Guillebaud, J., Turnbull, A.C. Lancet (1976) [Pubmed]
  8. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Peterson, S.A., Klabunde, T., Lashuel, H.A., Purkey, H., Sacchettini, J.C., Kelly, J.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. Regulation of cyclic AMP formation in brain tissue by alpha-adrenergic receptors: requisite intermediacy of prostaglandins of the E series. Partington, C.R., Edwards, M.W., Daly, J.W. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  10. Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents. Miles, L.A., Burnier, J.P., Verlander, M.S., Goodman, M., Kleiss, A.J., Griffin, J.H. Blood (1981) [Pubmed]
  11. Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Lovering, A.L., Ride, J.P., Bunce, C.M., Desmond, J.C., Cummings, S.M., White, S.A. Cancer Res. (2004) [Pubmed]
  12. A comparative study of naproxen gel and flufenamic acid gel in the treatment of soft tissue injuries. Seligra, A., Inglés, F. Current medical research and opinion. (1990) [Pubmed]
  13. Photoallergic contact dermatitis due to flufenamic acid and etofenamate. Montoro, J., Rodriguez-Serna, M., Liñana, J.J., Ferré, M.A., Sanchez-Motilla, J.M. Contact Derm. (1997) [Pubmed]
  14. Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. Corasaniti, M.T., Melino, G., Navarra, M., Garaci, E., Finazzi-Agrò, A., Nisticò, G. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. (1995) [Pubmed]
  15. Effect of flufenamic acid on uterine contractions and plasma levels of 15-keto-13,14-dihydroprostaglandin F2alpha in preterm labor. Schwartz, A., Brook, I., Insler, V., Kohen, F., Zor, U., Lindner, H.R. Gynecol. Obstet. Invest. (1978) [Pubmed]
  16. Antimonial-induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes. Sudhandiran, G., Shaha, C. J. Biol. Chem. (2003) [Pubmed]
  17. Overexpression of a 123-kDa anion transport inhibitor binding protein and two cytoskeleton proteins in Drosophila Kc cell variants resistant to disulfonic stilbenes. Sherwood, A.C., John-Alder, K., Biessmann, H., Sanders, M.M. J. Biol. Chem. (1989) [Pubmed]
  18. Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes. Tahara, S., Fukuda, K., Kodama, H., Kato, T., Miyoshi, S., Ogawa, S. J. Am. Coll. Cardiol. (2001) [Pubmed]
  19. Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid. Zwart, R., Oortgiesen, M., Vijverberg, H.P. J. Neurosci. (1995) [Pubmed]
  20. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. Stout, C.E., Costantin, J.L., Naus, C.C., Charles, A.C. J. Biol. Chem. (2002) [Pubmed]
  21. Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids. Lyall, V., Pasley, H., Phan, T.H., Mummalaneni, S., Heck, G.L., Vinnikova, A.K., DeSimone, J.A. J. Gen. Physiol. (2006) [Pubmed]
  22. HPLC determination of etofenamate and flufenamic acid in biological material. Dannhardt, G., Laufer, S., Lehr, M. Clin. Chem. (1988) [Pubmed]
  23. Transient receptor potential-like channels mediate metabotropic glutamate receptor EPSCs in rat dopamine neurones. Bengtson, C.P., Tozzi, A., Bernardi, G., Mercuri, N.B. J. Physiol. (Lond.) (2004) [Pubmed]
  24. Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells. Braet, K., Aspeslagh, S., Vandamme, W., Willecke, K., Martin, P.E., Evans, W.H., Leybaert, L. J. Cell. Physiol. (2003) [Pubmed]
  25. An ex vivo method for evaluating prostaglandin synthetase activity in cortical slices of mouse brain. Shohami, E., Gross, J. J. Neurochem. (1985) [Pubmed]
  26. Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. Paik, J.H., Ju, J.H., Lee, J.Y., Boudreau, M.D., Hwang, D.H. J. Biol. Chem. (2000) [Pubmed]
  27. Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. Steckelbroeck, S., Oyesanmi, B., Jin, Y., Lee, S.H., Kloosterboer, H.J., Penning, T.M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  28. Androgen receptors in prostate cancer. Culig, Z., Klocker, H., Bartsch, G., Hobisch, A. Endocr. Relat. Cancer (2002) [Pubmed]
  29. Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Pocock, T.M., Foster, R.R., Bates, D.O. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  30. Identification of the binding site for a low-molecular-weight inhibitor of plasminogen activator inhibitor type 1 by site-directed mutagenesis. Björquist, P., Ehnebom, J., Inghardt, T., Hansson, L., Lindberg, M., Linschoten, M., Strömqvist, M., Deinum, J. Biochemistry (1998) [Pubmed]
  31. Flufenamic acid in treatment of primary spasmodic dysmenorrhoea. A double-blind crossover study. Kapadia, L., Elder, M.G. Lancet (1978) [Pubmed]
  32. Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. McCarty, N.A., McDonough, S., Cohen, B.N., Riordan, J.R., Davidson, N., Lester, H.A. J. Gen. Physiol. (1993) [Pubmed]
  33. Quantitative determination of flufenamic acid and its major metabolites in plasma by high-performance liquid chromatography. Kubo, O., Nishide, K., Kiriyama, N. J. Chromatogr. (1979) [Pubmed]
  34. Interrelation of permeation and penetration parameters obtained from in vitro experiments with human skin and skin equivalents. Wagner, H., Kostka, K.H., Lehr, C.M., Schaefer, U.F. Journal of controlled release : official journal of the Controlled Release Society. (2001) [Pubmed]
WikiGenes - Universities