Disease relevance of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

• This study demonstrated that Meridol reduced plaque accumulation, retarded gingivitis development, possessed a definite bactericidal action, and produced only slight toothstaining [1].
• The aim of this study was to examine the effect of combined use of a toothpaste/mouthrinse containing amine fluoride/stannous fluoride (AmF/SnF2; meridol) on the development of white spot lesions, plaque, and gingivitis on maxillary anterior teeth in orthodontic patients [2].
• The aim of this in vitro study was to compare the effect of three mouthrinses: Meridol, an organic amine/ stannous fluoride solution; Parodontax, containing herbal ingredients; and an 0.8 % Emser salt solution, on the growth of oral bacteria and dental plaque [3].

High impact information on 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

• The gingival index scores in the Meridol group were higher than in the chlorhexidine group and lower than in the placebo group [1].
• Hardness measurements were carried out on the polished and subsequently etched enamel surface, rinsed for 1 min in the mouth with 10 ml Meridol (GABA INT), containing 0.025% F as amine fluoride and stannous fluoride, and exposed alternatively to mastication of 20 g cheddar cheese for 5 min [4].
• 1. On day 3, the P1I values were 1.21 in the control group and 0.51, 0.37 and 0.14 after Listerine, Meridol and CHX use, respectively [5].
• PURPOSE: To examine the effect of toothbrushing with different brands of regular (Meridol, Colgate) and whitening toothpaste (Pearl Weiss, Rembrant, Email Diamant) on bacterial adhesion onto enamel surfaces in vitro [6].
• The median counts of colony forming units (CFU/ml) after rinsing with Meridol were significantly lower for both aerobes and anaerobes than before rinsing with Meridol [7].

Chemical compound and disease context of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

• Long-term effects of Meridol and chlorhexidine mouthrinses on plaque, gingivitis, staining, and bacterial vitality [1].
• Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality [8].

Biological context of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

• Average microhardness of enamel was determined on the surface at baseline, after exposing to an acidic beverage, after exposing to saliva and mastication of cheese, with and without a mouth F prerinse (10 ml Meridol containing 0.025% F) [9].
• Meridol and Pearl Weiss demonstrated a similar adhesion effect as the etching control while brushing with Colgate demonstrated the least bacterial adhesion [6].

Associations of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol with other chemical compounds

• Enamel specimens were flossed in vitro with "waxed" dental floss and then treated with water, Act, Meridol, or Elmex Gel to evaluate the effect of "waxed" floss on the enamel fluoride uptake and on the enamel dissolution rate [10].
• Moreover, previously reported results showing that Meridol solution containing SnF2 and amine fluoride 297 significantly decreased the in vitro dissolution rate of enamel were confirmed by the present study [10].

Analytical, diagnostic and therapeutic context of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

• The aim of the present study was to compare the effect on plaque growth and gingival response of Meridol, an amine/stannous fluoride solution, during a three-month investigation, with those of a placebo preparation as a negative control and a chlorhexidine solution as a positive control, in a double-blind study [1].
• So we can advise Elmex mouthwash for patients with TMA and NiTi-based orthodontics wires but we suggest Acorea or Meridol mouthwashes for patients with TiNb orthodontics wires [11].
• The PII, BC, CFU and PE values of the CHX and the Meridol groups differed significantly from those of the control group [5].
• Furthermore, it was also shown that a combination of habitual self-performed and non-supervised oral hygiene with Meridol or Listerine is more beneficial for plaque control than the use of mechanical oral hygiene alone [12].
• Caries and gingivitis prevention may benefit from chemotherapeutic plaque control, therefore we compared in a cross-over study with 5 subjects the anti-acidogenic effects of a single use of AmF-SnF2 mouthrinse solutions (Meridol with and without 5% alcohol) with baseline and with the effects of a placebo and a chlorhexidine mouthrinse (CHX) [13].

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