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Chemical Compound Review

Meridol     2-[3-(bis(2- hydroxyethyl)amino)propyl...

Synonyms: AG-D-45402, ACMC-20mp55, AC1L3TPV, CTK0I0676, 120812-75-1
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Disease relevance of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

  • This study demonstrated that Meridol reduced plaque accumulation, retarded gingivitis development, possessed a definite bactericidal action, and produced only slight toothstaining [1].
  • The aim of this study was to examine the effect of combined use of a toothpaste/mouthrinse containing amine fluoride/stannous fluoride (AmF/SnF2; meridol) on the development of white spot lesions, plaque, and gingivitis on maxillary anterior teeth in orthodontic patients [2].
  • The aim of this in vitro study was to compare the effect of three mouthrinses: Meridol, an organic amine/ stannous fluoride solution; Parodontax, containing herbal ingredients; and an 0.8 % Emser salt solution, on the growth of oral bacteria and dental plaque [3].

High impact information on 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol


Chemical compound and disease context of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol


Biological context of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

  • Average microhardness of enamel was determined on the surface at baseline, after exposing to an acidic beverage, after exposing to saliva and mastication of cheese, with and without a mouth F prerinse (10 ml Meridol containing 0.025% F) [9].
  • Meridol and Pearl Weiss demonstrated a similar adhesion effect as the etching control while brushing with Colgate demonstrated the least bacterial adhesion [6].

Associations of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol with other chemical compounds

  • Enamel specimens were flossed in vitro with "waxed" dental floss and then treated with water, Act, Meridol, or Elmex Gel to evaluate the effect of "waxed" floss on the enamel fluoride uptake and on the enamel dissolution rate [10].
  • Moreover, previously reported results showing that Meridol solution containing SnF2 and amine fluoride 297 significantly decreased the in vitro dissolution rate of enamel were confirmed by the present study [10].

Analytical, diagnostic and therapeutic context of 2-[2-hydroxyethyl-[3-(2-hydroxyethyl-octadecyl-amino)propyl]amino]ethanol

  • The aim of the present study was to compare the effect on plaque growth and gingival response of Meridol, an amine/stannous fluoride solution, during a three-month investigation, with those of a placebo preparation as a negative control and a chlorhexidine solution as a positive control, in a double-blind study [1].
  • So we can advise Elmex mouthwash for patients with TMA and NiTi-based orthodontics wires but we suggest Acorea or Meridol mouthwashes for patients with TiNb orthodontics wires [11].
  • The PII, BC, CFU and PE values of the CHX and the Meridol groups differed significantly from those of the control group [5].
  • Furthermore, it was also shown that a combination of habitual self-performed and non-supervised oral hygiene with Meridol or Listerine is more beneficial for plaque control than the use of mechanical oral hygiene alone [12].
  • Caries and gingivitis prevention may benefit from chemotherapeutic plaque control, therefore we compared in a cross-over study with 5 subjects the anti-acidogenic effects of a single use of AmF-SnF2 mouthrinse solutions (Meridol with and without 5% alcohol) with baseline and with the effects of a placebo and a chlorhexidine mouthrinse (CHX) [13].


  1. Long-term effects of Meridol and chlorhexidine mouthrinses on plaque, gingivitis, staining, and bacterial vitality. Brecx, M., Macdonald, L.L., Legary, K., Cheang, M., Forgay, M.G. J. Dent. Res. (1993) [Pubmed]
  2. A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and initial caries lesion development in orthodontic patients. Øgaard, B., Alm, A.A., Larsson, E., Adolfsson, U. European journal of orthodontics. (2006) [Pubmed]
  3. Effect of three mouthrinses, containing amine/stannous fluoride, herbal extracts or Emser salt on the growth of oral bacteria--an in vitro study. Kagermeier-Callaway, A.S., Bredick, J., Willershausen, B. Eur. J. Med. Res. (2000) [Pubmed]
  4. Fluoride and hard cheese exposure on etched enamel in neck-irradiated patients in situ. Gedalia, I., Braustein, E., Lewinstein, I., Shapira, L., Ever-Hadani, P., Sela, M. Journal of dentistry. (1996) [Pubmed]
  5. Plaque bacteria counts and vitality during chlorhexidine, meridol and listerine mouthrinses. Netuschil, L., Weiger, R., Preisler, R., Brecx, M. Eur. J. Oral Sci. (1995) [Pubmed]
  6. Formation of Streptococcus mutans biofilm following toothbrushing with regular and whitening toothpastes. Steinberg, D., Mor, C., Dogan, H., Kaufmann, D., Rotstein, I. American journal of dentistry. (2003) [Pubmed]
  7. Inhibition of microflora associated with oral malignancy. Nagy, K., Szöke, I., Sonkodi, I., Nagy, E., Mari, A., Szolnoky, G., Newman, H.N. Oral Oncol. (2000) [Pubmed]
  8. Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality. Brecx, M., Netuschil, L., Reichert, B., Schreil, G. Journal of clinical periodontology. (1990) [Pubmed]
  9. Effect of hard cheese exposure, with and without fluoride prerinse, on the rehardening of softened human enamel. Gedalia, I., Davidov, I., Lewinstein, I., Shapira, L. Caries Res. (1992) [Pubmed]
  10. No effect of waxed dental floss on enamel fluoride uptake or on enamel dissolution changes. Barbakow, F., Imfeld, T., Sener, B. Schweizer Monatsschrift für Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia / SSO. (1989) [Pubmed]
  11. Influence of fluoridated mouthwashes on corrosion resistance of orthodontics wires. Schiff, N., Grosgogeat, B., Lissac, M., Dalard, F. Biomaterials (2004) [Pubmed]
  12. Efficacy of Listerine, Meridol and chlorhexidine mouthrinses as supplements to regular tooth cleaning measures. Brecx, M., Brownstone, E., MacDonald, L., Gelskey, S., Cheang, M. Journal of clinical periodontology. (1992) [Pubmed]
  13. Acidogenicity of buccal plaque after a single rinse with amine fluoride - stannous fluoride mouthrinse solution. Damen, J.J., Buijs, M.J., ten Cate, J.M. Caries Res. (2002) [Pubmed]
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