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Chemical Compound Review

Listerine     5-methyl-2-propan-2-yl- cyclohexan-1-ol; 5...

Synonyms: LS-175244, AC1L3GA2, 51273-66-6, C10H14O.C10H18O.C10H20O
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Disease relevance of Listerine


Psychiatry related information on Listerine

  • Several candidate mouthrinses containing essential oils (Listerine), ZnCl2, or an oil, water and cetylpyridum chloride mouthrinse have reduced the organoleptic scores of individuals with moderate levels of oral malodor in the absence of tongue brushing [6].

High impact information on Listerine

  • The amount of chlorhexidine required to achieve an equivalent growth inhibition against the biofilm cultures was reduced 4-10-fold in combination with cinnamon, manuka, L. morrisonii, thymol, and Listerine [7].
  • The essential oils included cinnamon, tea-tree (Melaleuca alternifola), manuka (Leptospermum scoparium), Leptospermum morrisonii, arnica, eucalyptus, grapefruit, the essential oil mouthrinse Cool Mint Listerine and two of its components, menthol and thymol [7].
  • This study's purpose was to compare the effectiveness of water versus Listerine (Warner Lambert, Lititz, PA) in removing FP from the oropharyngeal mucosa [8].
  • Microbial studies have shown that the effect of listerine is exerted against the total microbial mass and results in an overall decrease in both the biomass and the activity [9].
  • Both patients indicated regular use of Listerine Cool Mint PocketPaks Oral Care Strips [5].

Chemical compound and disease context of Listerine


Biological context of Listerine

  • Listerine showed no significant inhibition of glycolysis at any time point [14].
  • The antiviral activity of Listerine is thus not related to the viral genome but is probably directed to the viral envelope [15].
  • These results suggest that a brief exposure to Listerine produces significant morphological changes which may be associated with cell death and may help explain the alteration of surface-associated activities demonstrated in previous studies [16].
  • Two microbiology studies have demonstrated that no resistant microorganisms, opportunistic microorganisms, or presumptive oral pathogens emerge as a result of long-term, daily Listerine use [17].

Anatomical context of Listerine

  • According to these results, Listerine appears to be effective as a solution used for cleansing the oral cavity and dentures [18].
  • The mechanism of action of Listerine involves bacterial cell wall destruction, bacterial enzymatic inhibition, and extraction of bacterial lipopolysaccharides [19].
  • Follow-up appointments suggest an allergic contact focal erythema caused by prolonged contact with the irritant, in this case due to use of Listerine Cool Mint PocketPaks Oral Care Strips [5].

Associations of Listerine with other chemical compounds


Gene context of Listerine

  • H. pylori, MRSA and C. albicans were also reduced by a 30-sec exposure to the Listerine mouth rinse [13].
  • Cool Mint Listerine had almost the same antiseptic effect against tested microorganisms [23].
  • The intraoral antimicrobial activity of four commercial oral products-conventional NaF dentifrice (Crest), baking soda/peroxide/NaF dentifrice (Mentadent), essential oil mouthrinse (Listerine) and SnF2 dentifrice (Crest Plus Gum Care)-have been compared in three test regimens [24].
  • RESULTS: Statistical analyses (Repeated Measures ANOVA and Tukey test at 0.05 significance level) showed significant differences among KHN of t wo experimental groups (mean values): Listerine (49.17) and Plax (51.14) [25].

Analytical, diagnostic and therapeutic context of Listerine

  • Following the baseline examinations, subjects received half-mouth prophylaxes, and began 2 x daily supervised rinsing either with listerine for 30 or 60 s or with a control mouthrinse for 30 s as their sole oral hygiene measure [26].
  • Listerine showed a significant reduction in bacterial counts for up to 1 hour postrinsing, compared with prerinse counts, but the effect was less sustained [14].
  • Listerine, and placebo were tested in a complete crossover design [14].
  • This study determined the in vivo interproximal bactericidal efficacy of an essential oil-containing antiseptic mouthrinse (Listerine Antiseptic) following toothbrushing [27].
  • Comparison of Listerine mouthwash and periodontal dressing following periodontal flap surgery. I. Initial findings [28].


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  3. Determination of the in situ bactericidal activity of an essential oil mouthrinse using a vital stain method. Pan, P., Barnett, M.L., Coelho, J., Brogdon, C., Finnegan, M.B. Journal of clinical periodontology. (2000) [Pubmed]
  4. The efficacy of antimicrobial mouth rinses in oral health care. Okuda, K., Adachi, M., Iijima, K. Bull. Tokyo Dent. Coll. (1998) [Pubmed]
  5. Palatal erythema in patients using Listerine Cool Mint PocketPaks Oral Care Strips: case reports. Pham, C.L., Wood, A.J., Lambert, M.B., Carpenter, W. Journal of dentistry for children (Chicago, Ill.) (2005) [Pubmed]
  6. Microbiology and treatment of halitosis. Loesche, W.J., Kazor, C. Periodontology 2000. (2002) [Pubmed]
  7. Antimicrobial effects of essential oils in combination with chlorhexidine digluconate. Filoche, S.K., Soma, K., Sissons, C.H. Oral Microbiol. Immunol. (2005) [Pubmed]
  8. Does using a mouthwash instead of water improve the oropharyngeal removal of inhaled flovent (fluticasone propionate)? Kelloway, J.S., Wyatt, N.N., Adlis, S., Schoenwetter, W.F. Allergy and asthma proceedings : the official journal of regional and state allergy societies. (2001) [Pubmed]
  9. Microbiological effects of mouthrinses containing antimicrobials. Walker, C.B. Journal of clinical periodontology. (1988) [Pubmed]
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  11. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. Overholser, C.D., Meiller, T.F., DePaola, L.G., Minah, G.E., Niehaus, C. Journal of clinical periodontology. (1990) [Pubmed]
  12. Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality. Brecx, M., Netuschil, L., Reichert, B., Schreil, G. Journal of clinical periodontology. (1990) [Pubmed]
  13. Bactericidal effects of mouth rinses on oral bacteria. Kasuga, Y., Ikenoya, H., Okuda, K. Bull. Tokyo Dent. Coll. (1997) [Pubmed]
  14. Clinical study of a C31G containing mouthrinse: effect on salivary microorganisms. Corner, A.M., Brightman, V.J., Cooper, S., Yankell, S.L., Malamud, D. The Journal of clinical dentistry. (1990) [Pubmed]
  15. The antiviral spectrum of Listerine antiseptic. Dennison, D.K., Meredith, G.M., Shillitoe, E.J., Caffesse, R.G. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1995) [Pubmed]
  16. Antiseptic mouthrinse-induced microbial cell surface alterations. Kubert, D., Rubin, M., Barnett, M.L., Vincent, J.W. American journal of dentistry. (1993) [Pubmed]
  17. Long-term effects of Listerine antiseptic on dental plaque and gingivitis. Ross, N.M., Charles, C.H., Dills, S.S. The Journal of clinical dentistry. (1989) [Pubmed]
  18. Antibacterial effects of Listerine on oral bacteria. Kato, T., Iijima, H., Ishihara, K., Kaneko, T., Hirai, K., Naito, Y., Okuda, K. Bull. Tokyo Dent. Coll. (1990) [Pubmed]
  19. Antimicrobial mouthrinses: overview and update. Mandel, I.D. Journal of the American Dental Association (1939) (1994) [Pubmed]
  20. Efficacy of mouthrinses in inhibiting dental plaque and gingivitis in man. Axelsson, P., Lindhe, J. Journal of clinical periodontology. (1987) [Pubmed]
  21. Effects of topical oral antiseptic rinses on bacterial counts of saliva in healthy human subjects. Balbuena, L., Stambaugh, K.I., Ramirez, S.G., Yeager, C. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1998) [Pubmed]
  22. Antifungal activity of three mouth rinses--in vitro study. Abirami, C.P., Venugopal, P.V. Indian journal of pathology & microbiology. (2005) [Pubmed]
  23. Efficacy of Listerine antiseptic against MRSA, Candida albicans and HIV. Yamanaka, A., Hirai, K., Kato, T., Naito, Y., Okuda, K., Toda, S., Okuda, K. Bull. Tokyo Dent. Coll. (1994) [Pubmed]
  24. A comparison of intraoral antimicrobial effects of stabilized stannous fluoride dentifrice, baking soda/peroxide dentifrice, conventional NaF dentifrice and essential oil mouthrinse. Bacca, L.A., Leusch, M., Lanzalaco, A.C., Macksood, D., Bouwsma, O.J., Shaffer, J.B., Howard-Nordan, K.S., Knippenberg, S.H., Kreutzjans, M.K., Miller, J.M., Poore, C.L., Sunberg, R.J., Vastola, K.A., Becus, M., Bartizek, R.D., Block, R.P., Briner, W.W., White, D.J. The Journal of clinical dentistry. (1997) [Pubmed]
  25. Effect of different mouthrinses on Knoop hardness of a restorative composite. Cavalcanti, A.N., Mitsui, F.H., Ambrosano, G.M., Mathias, P., Marchi, G.M. American journal of dentistry. (2005) [Pubmed]
  26. Effect of rinsing time on antiplaque-antigingivitis efficacy of listerine. Ross, N.M., Mankodi, S.M., Mostler, K.L., Charles, C.H., Bartels, L.L. Journal of clinical periodontology. (1993) [Pubmed]
  27. In vivo antimicrobial activity of an essential oil-containing mouthrinse on interproximal plaque bacteria. Charles, C.H., Pan, P.C., Sturdivant, L., Vincent, J.W. The Journal of clinical dentistry. (2000) [Pubmed]
  28. Comparison of Listerine mouthwash and periodontal dressing following periodontal flap surgery. I. Initial findings. Yukna, R.A., Broxson, A.W., Mayer, E.T., Brite, D.V. Clinical preventive dentistry. (1986) [Pubmed]
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