Disease relevance of Listerine

• A comparative study of the different reactions of herpes simplex virus types 1 and 2 to Lysol, Listerine, bleach, rubbing alcohol, Alcide disinfectant (Alcide Corp., Westport, Conn.), and various pHs, temperatures, and UV light exposures was performed [1].
• CONCLUSION: It was suggested that the effect of Listerine on gingivitis is more pronounced than on plaque formation [2].
• This study was conducted to determine the bactericidal effect of an essential oil-containing mouthrinse (Listerine Antiseptic) on dental plaque bacteria in situ [3].
• Listerine was also weakly effective in inactivating human immunodeficiency viruses [4].
• Palatal erythema in patients using Listerine Cool Mint PocketPaks Oral Care Strips: case reports [5].

Psychiatry related information on Listerine

• Several candidate mouthrinses containing essential oils (Listerine), ZnCl2, or an oil, water and cetylpyridum chloride mouthrinse have reduced the organoleptic scores of individuals with moderate levels of oral malodor in the absence of tongue brushing [6].

High impact information on Listerine

• The amount of chlorhexidine required to achieve an equivalent growth inhibition against the biofilm cultures was reduced 4-10-fold in combination with cinnamon, manuka, L. morrisonii, thymol, and Listerine [7].
• The essential oils included cinnamon, tea-tree (Melaleuca alternifola), manuka (Leptospermum scoparium), Leptospermum morrisonii, arnica, eucalyptus, grapefruit, the essential oil mouthrinse Cool Mint Listerine and two of its components, menthol and thymol [7].
• This study's purpose was to compare the effectiveness of water versus Listerine (Warner Lambert, Lititz, PA) in removing FP from the oropharyngeal mucosa [8].
• Microbial studies have shown that the effect of listerine is exerted against the total microbial mass and results in an overall decrease in both the biomass and the activity [9].
• Both patients indicated regular use of Listerine Cool Mint PocketPaks Oral Care Strips [5].

Chemical compound and disease context of Listerine

• Thus far, published studies meeting these criteria support the efficacy of listerine and chlorhexidine as agents useful in reducing plaque and gingivitis [10].
• A 6-month double-blind, controlled clinical study was completed with 124 healthy adult subjects to determine the efficacy of 2 mouthrinses, Listerine (LA) and Peridex (PX), used as supplements to regular oral hygiene measures in reducing supragingival dental plaque and gingivitis [11].
• The experimental gingivitis model was used to compare the anti-plaque, anti-gingivitis and anti-microbial efficacies of a phenolic compound (Listerine) and an amine/stannous fluoride mouthwash (Meridol), using a placebo preparation as negative control and a chlorhexidine solution as positive control in a double-blind study [12].
• Bacteria in dental plaque were decreased by exposure to Listerine, Cool Mint Listerine, and povidone iodine for 30 seconds [13].

Biological context of Listerine

• Listerine showed no significant inhibition of glycolysis at any time point [14].
• The antiviral activity of Listerine is thus not related to the viral genome but is probably directed to the viral envelope [15].
• These results suggest that a brief exposure to Listerine produces significant morphological changes which may be associated with cell death and may help explain the alteration of surface-associated activities demonstrated in previous studies [16].
• Two microbiology studies have demonstrated that no resistant microorganisms, opportunistic microorganisms, or presumptive oral pathogens emerge as a result of long-term, daily Listerine use [17].

Anatomical context of Listerine

• According to these results, Listerine appears to be effective as a solution used for cleansing the oral cavity and dentures [18].
• The mechanism of action of Listerine involves bacterial cell wall destruction, bacterial enzymatic inhibition, and extraction of bacterial lipopolysaccharides [19].
• Follow-up appointments suggest an allergic contact focal erythema caused by prolonged contact with the irritant, in this case due to use of Listerine Cool Mint PocketPaks Oral Care Strips [5].

Associations of Listerine with other chemical compounds

• The members of the control group and the listerine group rinsed with 20 ml of the mouthrinse for 30 s, twice daily, while the members of the chlorhexidine groups (using either a 0.2% or a 0.1% solution) rinsed with 10 ml of the antiseptic solution for 60 s twice daily [20].
• A randomized, prospective clinical trial was conducted to analyze and compare the effects of Listerine antiseptic and Peridex oral rinse on the aerobic and anaerobic bacterial counts in healthy human subjects [21].
• The mouthrinses used were Povidone iodine ( Wokadine), Thymol with Eucalyptol and Benzoic acid (Listerine) and fluoride with Triclosan (Colgate Plax), which were tested against oral isolates of different species of Candida [22].

Gene context of Listerine

• H. pylori, MRSA and C. albicans were also reduced by a 30-sec exposure to the Listerine mouth rinse [13].
• Cool Mint Listerine had almost the same antiseptic effect against tested microorganisms [23].
• The intraoral antimicrobial activity of four commercial oral products-conventional NaF dentifrice (Crest), baking soda/peroxide/NaF dentifrice (Mentadent), essential oil mouthrinse (Listerine) and SnF2 dentifrice (Crest Plus Gum Care)-have been compared in three test regimens [24].
• RESULTS: Statistical analyses (Repeated Measures ANOVA and Tukey test at 0.05 significance level) showed significant differences among KHN of t wo experimental groups (mean values): Listerine (49.17) and Plax (51.14) [25].

Analytical, diagnostic and therapeutic context of Listerine

• Following the baseline examinations, subjects received half-mouth prophylaxes, and began 2 x daily supervised rinsing either with listerine for 30 or 60 s or with a control mouthrinse for 30 s as their sole oral hygiene measure [26].
• Listerine showed a significant reduction in bacterial counts for up to 1 hour postrinsing, compared with prerinse counts, but the effect was less sustained [14].
• Listerine, and placebo were tested in a complete crossover design [14].
• This study determined the in vivo interproximal bactericidal efficacy of an essential oil-containing antiseptic mouthrinse (Listerine Antiseptic) following toothbrushing [27].
• Comparison of Listerine mouthwash and periodontal dressing following periodontal flap surgery. I. Initial findings [28].

References