Chemical Compound Review:
PDDF 2-[[4-[(2-amino-4-oxo-1H- quinazolin-6...
Synonyms:
CHEMBL422395, CB-3717, CHEBI:129325, ICI-155387, NSC-327182, ...
- Intestinal alkaline phosphatase isoenzyme in patients with primary liver cancer during treatment with N10-propargyl 5, 8-dideazafolic acid (CB 3717). Buamah, P.K., Skillen, A.W., Cassells-Smith, A.J., James, O.F., Harris, A.L. Journal of surgical oncology. (1988)
- Phase II study of the antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717) in advanced breast cancer. Cantwell, B.M., Macaulay, V., Harris, A.L., Kaye, S.B., Smith, I.E., Milsted, R.A., Calvert, A.H. European journal of cancer & clinical oncology. (1988)
- Polyamines in testosterone-induced hypertrophic and antifolate-induced hyperplastic mouse kidney. Differential effect of alpha-difluoromethylornithine. Manteuffel-Cymborowska, M., Chmurzyńska, W., Grzelakowska-Sztabert, B. Biochim. Biophys. Acta (1993)
- Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB 3717). Calvert, A.H., Newell, D.R., Jackman, A.L., Gumbrell, L.A., Sikora, E., Grzelakowska-Sztabert, B., Bishop, J.A., Judson, I.R., Harland, S.J., Harrap, K.R. NCI monographs : a publication of the National Cancer Institute. (1987)
- Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid. Lorico, A., Toffoli, G., Boiocchi, M., Erba, E., Broggini, M., Rappa, G., D'Incalci, M. Cancer Res. (1988)
- Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate. Keyomarsi, K., Moran, R.G. J. Biol. Chem. (1990)
- Up-regulation of spermidine/spermine N1-acetyltransferase (SSAT) expression is a part of proliferative but not anabolic response of mouse kidney. Dudkowska, M., Stachurska, A., Grzelakowska-Sztabert, B., Manteuffel-Cymborowska, M. Acta Biochim. Pol. (2002)
- Thermodynamic study of the interaction of methotrexate, its metabolites, and new antifolates with thymidylate synthase: influence of FdUMP. Gilli, R., Lopez, C., Sari, J.C., Briand, C. Biochem. Pharmacol. (1990)
- The clinical pharmacokinetics of the novel antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717). Alison, D.L., Newell, D.R., Sessa, C., Harland, S.J., Hart, L.I., Harrap, K.R., Calvert, A.H. Cancer Chemother. Pharmacol. (1985)
- Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid. Li, S.W., Nair, M.G., Edwards, D.M., Kisliuk, R.L., Gaumont, Y., Dev, I.K., Duch, D.S., Humphreys, J., Smith, G.K., Ferone, R. J. Med. Chem. (1991)
- Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717. Curtin, N.J., Harris, A.L., James, O.F., Bassendine, M.F. Br. J. Cancer (1986)
- Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics. Jackman, A.L., Calvert, A.H., Hart, L.I., Harrap, K.R. Adv. Exp. Med. Biol. (1984)
- Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney. Manteuffel-Cymborowska, M., Chmurzyńska, W., Peska, M., Grzelakowska-Sztabert, B. Int. J. Biochem. Cell Biol. (1995)
- Mechanism of the induction of the differentiation of HL-60 leukemia cells by antifolates. Sokoloski, J.A., Beardsley, G.P., Sartorelli, A.C. Cancer Commun. (1989)
- Cross-talk between steroid-receptor-mediated and cell-membrane-receptor-mediated signalling pathways results in the in vivo modulation of c-Met and ornithine decarboxylase gene expression in mouse kidney. Dudkowska, M., Stachurska, A., Chmurzyska, W., Grzelakowska-Sztabert, B., Manteuffel-Cymborowska, M. Biochem. J. (2001)
- Cisplatin up-regulates the in vivo biosynthesis and degradation of renal polyamines and c-Myc expression. Stachurska, A., Dudkowska, M., Czopek, A., Manteuffel-Cymborowska, M., Grzelakowska-Sztabert, B. Biochim. Biophys. Acta (2004)
- Phase I study of the antifolate N10-propargyl-5,8-dideazafolic acid, CB 3717. Sessa, C., Zucchetti, M., Ginier, M., Willems, Y., D'Incalci, M., Cavalli, F. European journal of cancer & clinical oncology. (1988)