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Chemical Compound Review

p-Nonylphenol     4-nonylphenol

Synonyms: SPECTRUM330085, SureCN15887, CHEMBL153062, CCRIS 1251, LS-375, ...
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Disease relevance of CCRIS 1251


High impact information on CCRIS 1251


Chemical compound and disease context of CCRIS 1251


Biological context of CCRIS 1251


Anatomical context of CCRIS 1251


Associations of CCRIS 1251 with other chemical compounds


Gene context of CCRIS 1251


Analytical, diagnostic and therapeutic context of CCRIS 1251


  1. A novel metabolic pathway for degradation of 4-nonylphenol environmental contaminants by Sphingomonas xenophaga Bayram: ipso-hydroxylation and intramolecular rearrangement. Gabriel, F.L., Heidlberger, A., Rentsch, D., Giger, W., Guenther, K., Kohler, H.P. J. Biol. Chem. (2005) [Pubmed]
  2. Effect of endocrine disruptor para-nonylphenol on the cell growth and oxygen radical generation in Escherichia coli mutant cells deficient in catalase and superoxide dismutase. Okai, Y., Sato, E.F., Higashi-Okai, K., Inoue, M. Free Radic. Biol. Med. (2004) [Pubmed]
  3. Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna. LeBlanc, G.A., Mu, X., Rider, C.V. Environ. Health Perspect. (2000) [Pubmed]
  4. Dietary modulation of p-nonylphenol-induced polycystic kidneys in male Sprague-Dawley rats. Cooper, S., Latendresse, J.R., Doerge, D.R., Twaddle, N.C., Fu, X., Delclos, K.B. Toxicol. Sci. (2006) [Pubmed]
  5. Estrogen-like response to p-nonylphenol in human first trimester placenta and BeWo choriocarcinoma cells. Bechi, N., Ietta, F., Romagnoli, R., Focardi, S., Corsi, I., Buffi, C., Paulesu, L. Toxicol. Sci. (2006) [Pubmed]
  6. Stimulation of catecholamine synthesis by environmental estrogenic pollutants. Yanagihara, N., Toyohira, Y., Ueno, S., Tsutsui, M., Utsunomiya, K., Liu, M., Tanaka, K. Endocrinology (2005) [Pubmed]
  7. Nonylphenol induces the death of neural stem cells due to activation of the caspase cascade and regulation of the cell cycle. Kudo, C., Wada, K., Masuda, T., Yonemura, T., Shibuya, A., Fujimoto, Y., Nakajima, A., Niwa, H., Kamisaki, Y. J. Neurochem. (2004) [Pubmed]
  8. Development of direct ELISA for the determination of 4-nonylphenol and octylphenol. Zeravik, J., Skryjová, K., Nevoranková, Z., Fránek, M. Anal. Chem. (2004) [Pubmed]
  9. The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells. Vivacqua, A., Recchia, A.G., Fasanella, G., Gabriele, S., Carpino, A., Rago, V., Di Gioia, M.L., Leggio, A., Bonofiglio, D., Liguori, A., Maggiolini, M. Endocrine (2003) [Pubmed]
  10. Toxicity on crustaceans and endocrine disrupting activity on Saccharomyces cerevisiae of eight alkylphenols. Isidori, M., Lavorgna, M., Nardelli, A., Parrella, A. Chemosphere (2006) [Pubmed]
  11. Toxicity of 4-nonylphenol to Tubifex tubifex and Chironomus riparius in 28-day whole-sediment tests. Bettinetti, R., Provini, A. Ecotoxicol. Environ. Saf. (2002) [Pubmed]
  12. Bioaccumulation and toxicity of 4-nonylphenol (4-NP) and 4-(2-dodecyl)-benzene sulfonate (LAS) in Lumbriculus variegatus (Oligochaeta) and Chironomus riparius (Insecta). Mäenpää, K., Kukkonen, J.V. Aquat. Toxicol. (2006) [Pubmed]
  13. Estrogen-like properties of fluorotelomer alcohols as revealed by mcf-7 breast cancer cell proliferation. Maras, M., Vanparys, C., Muylle, F., Robbens, J., Berger, U., Barber, J.L., Blust, R., De Coen, W. Environ. Health Perspect. (2006) [Pubmed]
  14. Effects of 4-n-nonylphenol and tamoxifen on salmon gonadotropin-releasing hormone, estrogen receptor, and vitellogenin gene expression in juvenile rainbow trout. Vetillard, A., Bailhache, T. Toxicol. Sci. (2006) [Pubmed]
  15. Approaches for establishing predicted-no-effect concentrations for population-level ecological risk assessment in the context of chemical substances management. Lin, B.L., Tokai, A., Nakanishi, J. Environ. Sci. Technol. (2005) [Pubmed]
  16. Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive oxygen species in human blood neutrophils. Okai, Y., Sato, E.F., Higashi-Okai, K., Inoue, M. Environ. Health Perspect. (2004) [Pubmed]
  17. Endocrine disrupting chemicals (bisphenol A, 4-nonylphenol, 4-tert-octylphenol) modulate expression of two distinct cytochrome P450 aromatase genes differently in gender types of the hermaphroditic fish Rivulus marmoratus. Lee, Y.M., Seo, J.S., Kim, I.C., Yoon, Y.D., Lee, J.S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  18. Effects of para-nonylphenol on 92 kDa gelatinase secretion by human peripheral lymphocytes and U937 cells in vitro. Kubota, S., Ohara, S., Miyauchi, T., Edo, T., Takayama, E., Tomita, K., Seyama, Y. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  19. Biotransformation, tissue distribution, and persistence of 4-nonylphenol residues in juvenile rainbow trout (Oncorhynchus mykiss). Coldham, N.G., Sivapathasundaram, S., Dave, M., Ashfield, L.A., Pottinger, T.G., Goodall, C., Sauer, M.J. Drug Metab. Dispos. (1998) [Pubmed]
  20. Effect of 4-nonylphenol on cell proliferation and adipocyte formation in cultures of fully differentiated 3T3-L1 cells. Masuno, H., Okamoto, S., Iwanami, J., Honda, K., Shiosaka, T., Kidani, T., Sakayama, K., Yamamoto, H. Toxicol. Sci. (2003) [Pubmed]
  21. Multiwalled carbon nanotubes as a solid-phase extraction adsorbent for the determination of bisphenol A, 4-n-nonylphenol, and 4-tert-octylphenol. Cai, Y., Jiang, G., Liu, J., Zhou, Q. Anal. Chem. (2003) [Pubmed]
  22. Kinetics of calcium dissociation from its high-affinity transport sites on sarcoplasmic reticulum ATPase. Orlowski, S., Champeil, P. Biochemistry (1991) [Pubmed]
  23. Trophodynamic behavior of 4-nonylphenol and nonylphenol polyethoxylate in a marine aquatic food web from Bohai Bay, north China: comparison to DDTs. Hu, J., Jin, F., Wan, Y., Yang, M., An, L., An, W., Tao, S. Environ. Sci. Technol. (2005) [Pubmed]
  24. Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha expression by 4-nonylphenol in macrophages. You, H.J., Choi, C.Y., Jeon, Y.J., Chung, Y.C., Kang, S.K., Hahm, K.S., Jeong, H.G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  25. Metabolism of 4-n-nonylphenol by non-modified and CYP1A1- and CYP1A2-transgenic cell cultures of tobacco. Berger, A., S Russ, A., Schuphan, I., Schmidt, B. Z. Naturforsch., C, J. Biosci. (2005) [Pubmed]
  26. Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Gaido, K.W., Leonard, L.S., Lovell, S., Gould, J.C., Babaï, D., Portier, C.J., McDonnell, D.P. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  27. Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Tran, D.Q., Klotz, D.M., Ladlie, B.L., Ide, C.F., McLachlan, J.A., Arnold, S.F. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  28. Determination of 4-nonylphenol and 4-octylphenol in human blood samples by high-performance liquid chromatography with multi-electrode electrochemical coulometric-array detection. Inoue, K., Yoshimura, Y., Makino, T., Nakazawa, H. The Analyst. (2000) [Pubmed]
  29. Efficiency of supercritical fluid extraction for determining 4-nonylphenol in municipal sewage sludge. Lin, J.G., Arunkumar, R., Liu, C.H. Journal of chromatography. A. (1999) [Pubmed]
  30. Three-generation evaluation of dietary para-nonylphenol in CD (Sprague-Dawley) rats. Tyl, R.W., Myers, C.B., Marr, M.C., Castillo, N.P., Seely, J.C., Sloan, C.S., Veselica, M.M., Joiner, R.L., Van Miller, J.P., Simon, G.S. Toxicol. Sci. (2006) [Pubmed]
  31. Separation of technical 4-nonylphenols and their biodegradation products by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. Moeder, M., Martin, C., Schlosser, D., Harynuk, J., Górecki, T. Journal of chromatography. A. (2006) [Pubmed]
  32. Suppression of CYP1A1 expression by 4-nonylphenol in murine Hepa-1c1c7 cells. Jeong, H.G., Kim, J.Y., Choi, C.Y., You, H.J., Hahm, K. Cancer Lett. (2001) [Pubmed]
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