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Chemical Compound Review

CCRIS 252     2-methyl-4-(2- methylphenyl)aniline

Synonyms: CHEMBL310395, AG-D-69230, AG-D-91398, SureCN5888553, AC1Q2FKD, ...
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Disease relevance of NSC176336


High impact information on NSC176336


Chemical compound and disease context of NSC176336


Biological context of NSC176336


Anatomical context of NSC176336


Associations of NSC176336 with other chemical compounds


Gene context of NSC176336


Analytical, diagnostic and therapeutic context of NSC176336


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  2. Induction of prostate carcinoma in situ at high incidence in F344 rats by a combination of 3,2'-dimethyl-4-aminobiphenyl and ethinyl estradiol. Shirai, T., Fukushima, S., Ikawa, E., Tagawa, Y., Ito, N. Cancer Res. (1986) [Pubmed]
  3. Effect of intestinal microflora and dietary fat on 3,2'-dimethyl-4-aminobiphenyl-induced colon carcinogenesis in F344 rats. Reddy, B.S., Ohmori, T. Cancer Res. (1981) [Pubmed]
  4. Pancreatic acinar cell tumors in rats induced by 3,2'-dimethyl-4-aminobiphenyl. Shirai, T., Nakamura, A., Wada, S., Ito, N. Carcinogenesis (1989) [Pubmed]
  5. Effect of butylated hydroxytoluene and butylated hydroxyanisole on the mutagenicity of 3,2'-dimethyl-4-aminobiphenyl. Reddy, B.S., Sharma, C., Mathews, L. Nutrition and cancer. (1983) [Pubmed]
  6. Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl. Feng, Y., Wagner, R.J., Fretland, A.J., Becker, W.K., Cooley, A.M., Pretlow, T.P., Lee, K.J., Hein, D.W. Cancer Res. (1996) [Pubmed]
  7. Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate. Shirai, T., Tamano, S., Kato, T., Iwasaki, S., Takahashi, S., Ito, N. Cancer Res. (1991) [Pubmed]
  8. Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2'-dimethyl-4-aminobiphenyl. Ito, N., Shirai, T., Tagawa, Y., Nakamura, A., Fukushima, S. Cancer Res. (1988) [Pubmed]
  9. Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster. Hein, D.W., Doll, M.A., Xiao, G.H., Feng, Y. Pharmacogenetics (2003) [Pubmed]
  10. Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth. Rao, C.V., Desai, D., Kaul, B., Amin, S., Reddy, B.S. Chem. Biol. Interact. (1992) [Pubmed]
  11. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. Imaoka, S., Yoneda, Y., Matsuda, T., Degawa, M., Fukushima, S., Funae, Y. Biochem. Pharmacol. (1997) [Pubmed]
  12. Rat liver DNA damage by the non-hepatocarcinogen 3,2'-dimethyl-4-aminobiphenyl. Hellemann, A.L., Maslansky, C.J., Bosland, M., Williams, G.M. Cancer Lett. (1984) [Pubmed]
  13. Lack of tumorigenic response in the prostate gland of castrated F344 rats by 3,2'-dimethyl-4-aminobiphenyl given with methyltestosterone. Shirai, T., Tagawa, Y., Fukushima, S., Asamoto, M., Ito, N. Cancer Lett. (1987) [Pubmed]
  14. Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats. Zhao, L., Futakuchi, M., Suzuki, S., Ohhara, Y., Hashimoto, T., Suzuki, T., Manabe, T., Shirai, T. Clin. Exp. Metastasis (2005) [Pubmed]
  15. Species differences of glucuronidation and sulfation in relation to hepatocarcinogenesis. Bock, K.W., Schirmer, G. Arch. Toxicol. Suppl. (1987) [Pubmed]
  16. Formation of DNA adducts in vivo in rat liver and intestinal epithelium after administration of the carcinogen 3,2'-dimethyl-4-aminobiphenyl and its hydroxamic acid. Westra, J.G., Flammang, T.J., Fullerton, N.F., Beland, F.A., Weis, C.C., Kadlubar, F.F. Carcinogenesis (1985) [Pubmed]
  17. Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2'-dimethyl-4-aminobiphenyl. Masui, T., Shirai, T., Imaida, K., Hirose, M., Futakuchi, M., Tatematsu, M., Ito, N. Mol. Carcinog. (1995) [Pubmed]
  18. Establishment and characterization of three androgen-independent, metastatic carcinoma cell lines from 3,2'-dimethyl-4-aminobiphenyl-induced prostatic tumors in F344 rats. Nakanishi, H., Takeuchi, S., Kato, K., Shimizu, S., Kobayashi, K., Tatematsu, M., Shirai, T. Jpn. J. Cancer Res. (1996) [Pubmed]
  19. Immunohistochemical demonstration of 3,2'-dimethyl-4-aminobiphenyl DNA adduct formation in various organs of Syrian golden hamsters. Yaono, M., Hasegawa, R., Kato, K., Kimura, J., Lin, C., Tada, M., Shirai, T. Cancer Lett. (1996) [Pubmed]
  20. Lack of synergism among DMAB, BOP, and MNU in induction of carcinomas of the rat ventral prostate. Shirai, T., Yamamoto, A., Imaida, K., Tamano, S., Mori, T., Hasegawa, R. Teratog., Carcinog. Mutagen. (1992) [Pubmed]
  21. Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2'-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation. Shirai, T., Fukushima, S., Kawabe, M., Shibata, M., Iwasaki, S., Tada, M., Ito, N. Carcinogenesis (1991) [Pubmed]
  22. Immunohistochemical detection of carcinogen-DNA adducts in normal human prostate tissues transplanted into the subcutis of athymic nude mice: results with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3,2'-dimethyl-4-aminobiphenyl (DMAB) and relation to cytochrome P450s and N-acetyltransferase activity. Cui, L., Takahashi, S., Tada, M., Kato, K., Yamada, Y., Kohri, K., Shirai, T. Jpn. J. Cancer Res. (2000) [Pubmed]
  23. Carcinogenesis in accessory sex organs of rats induced by 3,2'-dimethyl-4-aminobiphenyl: response to androgen deprivation. Tamura, Y., Ono, Y., Suzuki, T., Suzuki, K., Takezawa, Y., Mashimo, T., Fukabori, Y., Yuasa, H., Imai, K., Yamanaka, H., Suzuki, K. Histochem. Cell Biol. (1997) [Pubmed]
  24. Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. Kato, K., Takahashi, S., Cui, L., Toda, T., Suzuki, S., Futakuchi, M., Sugiura, S., Shirai, T. Jpn. J. Cancer Res. (2000) [Pubmed]
  25. Effect of acetylator genotype on 3,2'-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters. Paulsen, J.E., Steffensen, I.L., Namork, E., Hein, D.W., Alexander, J. Carcinogenesis (1996) [Pubmed]
  26. Protective effect of acetaminophen against colon cancer initiation effects of 3,2'-dimethyl-4-aminobiphenyl in rats. Williams, G.M., Iatropoulos, M.J., Jeffrey, A.M., Shirai, T. Eur. J. Cancer Prev. (2002) [Pubmed]
  27. Ultrasonic diagnosis of 3,2'-dimethyl-4-aminobiphenyl induced tumors in the urogenital organs of F344 rats. Suzuki, T., Tamura, Y., Takezawa, Y., Mashimo, T., Imai, K., Yuasa, H., Yamanaka, H., Shirai, T. Prostate (1993) [Pubmed]
  28. Trial to induce prostatic cancer in ACI/Seg rats treated with a combination of 3,2'-dimethyl-4-aminobiphenyl and ethinyl estradiol. Takai, K., Kakizoe, T., Tanaka, Y., Tobisu, K., Aso, Y. Jpn. J. Cancer Res. (1991) [Pubmed]
  29. Antimutagenicity of fermented milk. Nadathur, S.R., Gould, S.J., Bakalinsky, A.T. J. Dairy Sci. (1994) [Pubmed]
  30. Lobe specific effects of testosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Yaono, M., Tamano, S., Mori, T., Kato, K., Imaida, K., Asamoto, M., Shirai, T. Cancer Lett. (2000) [Pubmed]
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