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Chemical Compound Review

SureCN10141     4-(2,4,4-trimethylpentan-2- yl)phenol

Synonyms: CHEMBL259327, NSC-5427, NSC-7248, ACMC-1C0TS, CCRIS 8947, ...
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Disease relevance of NSC7248

  • In the present study, acute and chronic aquatic toxicity and the estrogenic activity of the following eight alkylphenols were assessed: 4-nonylphenol, 4-octylphenol, 4-nonylphenol-10-ethoxylate, 4-tert-octylphenol, POE (1 to 2)-nonylphenol, POE (6)-nonylphenol, POE (3)-tert-octylphenol and POE (9 to 10)-tert-octylphenol [1].

High impact information on NSC7248


Biological context of NSC7248


Anatomical context of NSC7248


Associations of NSC7248 with other chemical compounds


Gene context of NSC7248


Analytical, diagnostic and therapeutic context of NSC7248


  1. Toxicity on crustaceans and endocrine disrupting activity on Saccharomyces cerevisiae of eight alkylphenols. Isidori, M., Lavorgna, M., Nardelli, A., Parrella, A. Chemosphere (2006) [Pubmed]
  2. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. Routledge, E.J., White, R., Parker, M.G., Sumpter, J.P. J. Biol. Chem. (2000) [Pubmed]
  3. Multiwalled carbon nanotubes as a solid-phase extraction adsorbent for the determination of bisphenol A, 4-n-nonylphenol, and 4-tert-octylphenol. Cai, Y., Jiang, G., Liu, J., Zhou, Q. Anal. Chem. (2003) [Pubmed]
  4. Exposure to 4-tert-octylphenol accelerates sexual differentiation and disrupts expression of steroidogenic factor 1 in developing bullfrogs. Mayer, L.P., Dyer, C.A., Propper, C.R. Environ. Health Perspect. (2003) [Pubmed]
  5. Toxic effects of in vitro exposure to p-tert-octylphenol on bovine oocyte maturation and developmental competence. Pocar, P., Augustin, R., Gandolfi, F., Fischer, B. Biol. Reprod. (2003) [Pubmed]
  6. Exposure of neonatal female rats to p-tert-octylphenol disrupts afternoon surges of luteinizing hormone, follicle-stimulating hormone and prolactin secretion, and interferes with sexual receptive behavior in adulthood. Herath, C.B., Watanabe, G., Katsuda , S., Yoshida, M., Suzuki, A.K., Taya, K. Biol. Reprod. (2001) [Pubmed]
  7. Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Boockfor, F.R., Blake, C.A. Biol. Reprod. (1997) [Pubmed]
  8. Tissue distribution and depuration of 4-tert-octylphenol residues in the cyprinid fish, Scardinius erythrophthalmus. Pedersen, R.T., Hill, E.M. Environ. Sci. Technol. (2002) [Pubmed]
  9. Sorption and remobilization behavior of 4-tert-octylphenol in aquatic systems. Zhou, J.L. Environ. Sci. Technol. (2006) [Pubmed]
  10. Toxicokinetics of p-tert-octylphenol in female DA/Han rats after single i.v. and oral application. Upmeier, A., Degen, G.H., Schuhmacher, U.S., Certa, H., Bolt, H.M. Arch. Toxicol. (1999) [Pubmed]
  11. Octylphenol induces apoptosis in cultured rat Sertoli cells. Qian, J., Bian, Q., Cui, L., Chen, J., Song, L., Wang, X. Toxicol. Lett. (2006) [Pubmed]
  12. Effects of neonatal exposure to 4-tert-octylphenol, diethylstilbestrol, and flutamide on steroidogenesis in infantile rat testis. Mikkilä, T.F., Toppari, J., Paranko, J. Toxicol. Sci. (2006) [Pubmed]
  13. Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway. Masuno, H., Iwanami, J., Kidani, T., Sakayama, K., Honda, K. Toxicol. Sci. (2005) [Pubmed]
  14. Exposure to 4-tert-octylphenol, an environmentally persistent alkylphenol, enhances interleukin-4 production in T cells via NF-AT activation. Lee, M.H., Kim, E., Kim, T.S. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  15. Identification of novel metabolites of the xenoestrogen 4-tert-octylphenol in primary rat hepatocytes. Pedersen, R.T., Hill, E.M. Chem. Biol. Interact. (2000) [Pubmed]
  16. Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Laws, S.C., Carey, S.A., Ferrell, J.M., Bodman, G.J., Cooper, R.L. Toxicol. Sci. (2000) [Pubmed]
  17. Differential estrogen receptor binding of estrogenic substances: a species comparison. Matthews, J., Celius, T., Halgren, R., Zacharewski, T. J. Steroid Biochem. Mol. Biol. (2000) [Pubmed]
  18. Exposures to estradiol, ethinylestradiol and octylphenol affect survival and growth of Rana pipiens and Rana sylvatica tadpoles. Hogan, N.S., Lean, D.R., Trudeau, V.L. J. Toxicol. Environ. Health Part A (2006) [Pubmed]
  19. p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats. Funabashi, T., Nakamura, T.J., Kimura, F. J. Neuroendocrinol. (2004) [Pubmed]
  20. Infantile 4-tert-octylphenol exposure transiently inhibits rat ovarian steroidogenesis and steroidogenic acute regulatory protein (StAR) expression. Myllymäki, S.A., Karjalainen, M., Haavisto, T.E., Toppari, J., Paranko, J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  21. Neonatal exposure to p-tert-octylphenol causes abnormal expression of estrogen receptor alpha and subsequent alteration of cell proliferating activity in the developing Donryu rat uterus. Yoshida, M., Takenaka, A., Katsuda, S., Kurokawa, Y., Maekawa, A. Toxicologic pathology. (2002) [Pubmed]
  22. Effects of 4-tert-octylphenol on initiation and maintenance of pregnancy following oral administration during early pregnancy in rats. Harazono, A., Ema, M. Toxicol. Lett. (2001) [Pubmed]
  23. Oral single pulse exposure of flounder Platichthys flesus to 4-tert-octylphenol: Relations between tissue levels and estrogenic effects. Madsen, L.L., Korsgaard, B., Bjerregaard, P. Mar. Environ. Res. (2006) [Pubmed]
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