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MeSH Review

Mandibular Nerve

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Disease relevance of Mandibular Nerve


High impact information on Mandibular Nerve


Chemical compound and disease context of Mandibular Nerve


Biological context of Mandibular Nerve


Anatomical context of Mandibular Nerve


Associations of Mandibular Nerve with chemical compounds

  • The same afferent axons appear to be involved in the two effects, as indicated by the intensity function, the electrical excitability, the afferent conduction velocity and the lack of differential effect of Xylocaine infiltration of the inferior alveolar nerve [20].
  • Patients were allocated randomly to one of two groups: group B (n = 20) received bupivacaine up to 2 mg kg-1, infiltrated around the inferior alveolar nerves bilaterally, and group K (n = 20) received ketorolac 10 mg i.v. at the start of surgery [21].
  • Proportion of unmyelinated axons in the rat inferior alveolar nerve and mandibular molar pulps after neonatal administration of capsaicin [22].
  • RESULTS: Patients who received only dipyrone had significantly reduced lingual and inferior alveolar nerve electrical detection thresholds 2 days after surgery, which returned to nearly baseline values by the eighth day postoperatively [2].
  • Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats [19].

Gene context of Mandibular Nerve

  • The involvement of brain-derived neurotrophic factor (BDNF) in the regeneration of periodontal Ruffini endings following transection of the inferior alveolar nerve [23].
  • By immunohistochemical staining at embryonic day (E) 9.5, MyoD1 and myogenin have been expressed in the mandibular arch, into which the mandibular nerve had not yet extended [24].
  • An immunoelectron microscopic method indicated that these endings were identical to Ruffini-like endings, 4% of trigeminal neurons retrogradely labeled from the inferior alveolar nerve coexpressed CR- and parvalbumin-irs [25].
  • One week following inferior alveolar nerve injury there was a dramatic decrease in the level of TrkB-like immunoreactivity labelling in the pulp, which paralleled an increase in the expression of Schwann cell low affinity neurotrophin receptor-like immunoreactivity [26].
  • These results would suggest that tactile hypersensitivity develops after inferior alveolar nerve injury and that NMDA receptor/NOS/NO production pathways in the SpVc may be involved in the development of such pathophysiological states [27].

Analytical, diagnostic and therapeutic context of Mandibular Nerve


  1. Proctolin in the innervation of the locust mandibular closer muscle modulates contractions through the elevation of inositol trisphosphate. Baines, R.A., Lange, A.B., Downer, R.G. J. Comp. Neurol. (1990) [Pubmed]
  2. Effect of dexamethasone and dipyrone on lingual and inferior alveolar nerve hypersensitivity following third molar extractions: preliminary report. Barron, R.P., Benoliel, R., Zeltser, R., Eliav, E., Nahlieli, O., Gracely, R.H. Journal of orofacial pain. (2004) [Pubmed]
  3. Continuous mandibular nerve block for pain relief. A report of two cases. Singh, B., Bhardwaj, V. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2002) [Pubmed]
  4. Intraoral monocortical miniplating of mandible fractures. Valentino, J., Levy, F.E., Marentette, L.J. Arch. Otolaryngol. Head Neck Surg. (1994) [Pubmed]
  5. Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis. Claffey, E., Reader, A., Nusstein, J., Beck, M., Weaver, J. Journal of endodontics. (2004) [Pubmed]
  6. Induction of Fos protein-like immunoreactivity in the trigeminal spinal nucleus caudalis and upper cervical cord following noxious and non-noxious mechanical stimulation of the whisker pad of the rat with an inferior alveolar nerve transection. Nomura, H., Ogawa, A., Tashiro, A., Morimoto, T., Hu, J.W., Iwata, K. Pain (2002) [Pubmed]
  7. Trigeminal ganglion neuronal activity and glial fibrillary acidic protein immunoreactivity after inferior alveolar nerve crush in the adult rat. Chudler, E.H., Anderson, L.C., Byers, M.R. Pain (1997) [Pubmed]
  8. Articaine is More Effective than Lidocaine or Mepivacaine in Rat Sensory Nerve Conduction Block in vitro. Potocnik, I., Tomsic, M., Sketelj, J., Bajrovic, F.F. J. Dent. Res. (2006) [Pubmed]
  9. The effect of substance P on the spontaneous discharge from injured inferior alveolar nerve fibres in the ferret. Smith, P.L., Loescher, A.R., Boissonade, F.M., Robinson, P.P. Exp. Neurol. (2005) [Pubmed]
  10. Receptive field properties of human periodontal afferents responding to loading of premolar and molar teeth. Johnsen, S.E., Trulsson, M. J. Neurophysiol. (2003) [Pubmed]
  11. Peripheral streptomycin/lidocaine injections in the treatment of idiopathic trigeminal neuralgia. A preliminary report. Sokolović, M., Todorović, L., Stajcić, Z., Petrović, V. Journal of maxillofacial surgery. (1986) [Pubmed]
  12. Paresthesia of the inferior alveolar nerve caused by Hydron: a case report. Pyner, D.A. Journal of endodontics. (1980) [Pubmed]
  13. Neurogenic inflammation and the oral mucosa. Györfi, A., Fazekas, A., Rosivall, L. Journal of clinical periodontology. (1992) [Pubmed]
  14. Regional anesthesia of the infraorbital and inferior alveolar nerves during noninvasive tooth pulp stimulation in halothane-anesthetized cats. Gross, M.E., Pope, E.R., Jarboe, J.M., O'Brien, D.P., Dodam, J.R., Polkow-Haight, J. Am. J. Vet. Res. (2000) [Pubmed]
  15. Anesthetic efficacy and heart rate effects of the intraosseous injection of 3% mepivacaine after an inferior alveolar nerve block. Gallatin, E., Stabile, P., Reader, A., Nist, R., Beck, M. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2000) [Pubmed]
  16. Expression of sodium channel SNS/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat. Bongenhielm, U., Nosrat, C.A., Nosrat, I., Eriksson, J., Fjell, J., Fried, K. Exp. Neurol. (2000) [Pubmed]
  17. Vascular permeability to lanthanum in the rat incisor pulp. Comparison with endoneurial vessels in the inferior alveolar nerve. Bishop, M.A. Cell Tissue Res. (1985) [Pubmed]
  18. The effect of pre-incisional infiltration with lignocaine on postoperative pain after molar teeth extraction under general anaesthesia. Tordoff, S.G., Brossy, M., Rowbotham, D.J., James, J.N., James, R., Raphael, J.H. Anaesthesia. (1996) [Pubmed]
  19. Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats. Sugimoto, T., Takemura, M., Okubo, J., Sakai, A. Brain Res. (1985) [Pubmed]
  20. Exteroceptive suppression and motor control of the masseter and temporalis muscles in normal man. Godaux, E., Desmedt, J.E. Brain Res. (1975) [Pubmed]
  21. Local anaesthetic infiltration for surgical exodontia of third molar teeth: a double-blind study comparing bupivacaine infiltration with i.v. ketorolac. Mellor, D.J., Mellor, A.H., McAteer, E.M. British journal of anaesthesia. (1998) [Pubmed]
  22. Proportion of unmyelinated axons in the rat inferior alveolar nerve and mandibular molar pulps after neonatal administration of capsaicin. Holje, L., Hildebrand, C., Fried, K. Brain Res. (1983) [Pubmed]
  23. The involvement of brain-derived neurotrophic factor (BDNF) in the regeneration of periodontal Ruffini endings following transection of the inferior alveolar nerve. Harada, F., Hoshino, N., Hanada, K., Kawano, Y., Atsumi, Y., Wakisaka, S., Maeda, T. Arch. Histol. Cytol. (2003) [Pubmed]
  24. Myogenic determination and differentiation of the mouse palatal muscle in relation to the developing mandibular nerve. Zhang, L., Yoshimura, Y., Hatta, T., Otani, H. J. Dent. Res. (1999) [Pubmed]
  25. Coexpression of calretinin and parvalbumin in Ruffini-like endings in the rat incisor periodontal ligament. Ichikawa, H., Jacobowitz, D.M., Sugimoto, T. Brain Res. (1997) [Pubmed]
  26. TrkB-like immunoreactivity in trigeminal sensory nerve fibers of the rat molar tooth pulp: development and response to nerve injury. Foster, E., Risling, M., Fried, K. Brain Res. (1995) [Pubmed]
  27. Involvement of NMDA-nitric oxide pathways in the development of tactile hypersensitivity evoked by the loose-ligation of inferior alveolar nerves in rats. Yonehara, N., Kudo, C., Kamisaki, Y. Brain Res. (2003) [Pubmed]
  28. Thermographic assessment of reversible inferior alveolar nerve deficit. Shetty, V., Gratt, B.M., Flack, V. Journal of orofacial pain. (1994) [Pubmed]
  29. Effects of peripheral axotomy of the inferior alveolar nerve on the levels of neuropeptide Y in rat trigeminal primary afferent neurons. Sasaki, Y., Wakisaka, S., Kurisu, K. Brain Res. (1994) [Pubmed]
  30. Regeneration of periodontal primary afferents of the rat incisor following injury of the inferior alveolar nerve with special reference to neuropeptide Y-like immunoreactive primary afferents. Youn, S.H., Sakuda, M., Kurisu, K., Wakisaka, S. Brain Res. (1997) [Pubmed]
  31. Vasodilatation in the dental pulp produced by electrical stimulation of the inferior alveolar nerve in the cat. Gazelius, B., Olgart, L. Acta Physiol. Scand. (1980) [Pubmed]
  32. Application of a mandibular nerve block using an indwelling catheter for intractable cancer pain. Kohase, H., Umino, M., Shibaji, T., Suzuki, N. Acta anaesthesiologica Scandinavica. (2004) [Pubmed]
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