The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L4IDN     2-diethylaminoethyl 3-methyl-2-phenyl...

Synonyms: LS-161130, C 1997, 29620-39-1
This record was replaced with 207303.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC165857

  • This enzyme released KDO from different LPSs, including Re-LPS from Escherichia coli and Salmonella minnesota, Rd-LPS from S. minnesota, and de-O-acyl-Re-LPS (Kiang, J., Szu, S. C., Wang, L.X., Tang, M., and Lee, Y. C. (1997) Anal. Biochem. 245, 97-101) [1].
  • By activation of the silent and divergent psbA1 gene in the cyanobacterium Synechocystis 6803, a novel D1 protein, D1', was produced [Salih, G. & Jansson, C. (1997) Plant Cell 9, 869-878] [2].

Psychiatry related information on NSC165857

  • A moving cast shadow of the object affects the perception of the object's trajectory in adults [Kersten, D., Mamassian, P., & Knill, D. C. (1997). Moving cast shadow induce apparent motion in depth. Perception, 26, 171-192] [3].

High impact information on NSC165857

  • We have previously demonstrated that oxidized low density lipoprotein (OxLDL) will increase expression of another class B scavenger receptor, CD36 (Han, J., Hajjar, D. P., Febbraio, M., and Nicholson, A. C. (1997) J. Biol. Chem. 272, 21654-21659) [4].
  • Gel filtration chromatography of leukocyte cytosol revealed a peak of PA-dependent Tyr phosphorylating activity distinct from a previously described PA-dependent phosphorylating activity (Waite, K. A., Wallin, R., Qualliotine-Mann, D., and McPhail, L. C. (1997) J. Biol. Chem. 272, 15569-15578) [5].
  • We have recently cloned MMP-19, a novel matrix metalloproteinase, which, due to unique structural features, was proposed to represent the first member of a new MMP subfamily (Pendás, A. M., Knäuper, V. , Puente, X. S., Llano, E., Mattei, M. G., Apte, S., Murphy, G., and López-Otin, C. (1997) J. Biol. Chem. 272, 4281-4286) [6].
  • We have shown previously that betaAPP can be phosphorylated within secretory vesicles and at the cell surface (Walter, J., Capell, A., Hung, A. Y. , Langen, H., Schnölzer, M., Thinakaran, G., Sisodia, S. S., Selkoe, D. J., and Haass, C. (1997) J. Biol. Chem. 272, 1896-1903) [7].
  • C. (1997) Proc. Natl. Acad. Sci. U [8].

Biological context of NSC165857

  • This enzyme has a substrate specificity distinct from other PKC isoforms (Nishikawa, K., Toker, A., Johannes, F. J., Songyang, Z., and Cantley, L. C. (1997) J. Biol. Chem. 272, 952-960), and its mechanism of regulation is not yet clear [9].
  • Site-directed mutants of eEF1A (formerly eEF-1alpha) were generated using a modification of a highly versatile yeast shuttle vector (Cavallius, J., Popkie, A. P., and Merrick, W. C. (1997) Biochim. Biophys. Acta 1350, 345-358) [10].
  • This region mediates cell adhesion when provided as an artificial substratum and is localized within amino acids 56-109 of the recombinant extracellular protein domain of mouse syndecan-4 (mS4ED) (McFall, A. J., and Rapraeger, A. C. (1997) J. Biol. Chem. 272, 12901-12904) [11].
  • Sp1 sites can mediate growth/cell cycle induction of dihydrofolate reductase in late G1 (Jensen, D. E., Black, A. R. Swick, A. G., and Azizkhan, J. C. (1997) J. Cell. Biochem. 67, 24-31) [12].
  • This work establishes that substrate binds only to the first metal binding site in AAP and thus substantiates the first step in catalysis in the recently proposed mechanism of action for AAP [Bennett, B., & Holz, R. C. (1997) J. Am. Chem. Soc. 119, 1923-1933; Chen, G., et al. (1997) Biochemistry 36, 4278-4286] [13].

Anatomical context of NSC165857

  • Bap31 is a polytopic integral membrane protein of the endoplasmic reticulum and forms a complex with Bcl-2/Bcl-XL and procaspase-8 (Ng, F. W. H., Nguyen, M., Kwan, T., Branton, P. E., Nicholson, W. D., Cromlish, J. A., and Shore, G. C. (1997) J. Cell Biol. 139, 327-338) [14].
  • Electrical stimulation of cardiac myocytes activates the c-Jun N-terminal kinase (McDonough, P. M., Hanford, D. S., Sprenkle, A. B., Mellon, N. R., and Glembotski, C. C. (1997) J. Biol. Chem. 272, 24046-24053) so that the fold-activation of the cyt c promoter is increased by pacing when either c-jun or c-fos/c-jun were cotransfected [15].

Gene context of NSC165857

  • Recently we isolated a distinct human PtdIns 4-kinase gene, named PI4Kbeta, that encodes an enzyme that is wortmannin sensitive (Meyers, R., and Cantley, L. C. (1997) J. Biol. Chem. 272, 4384-4390) [16].
  • The differential display (DD) was employed to identify the gene(s) responsible for 1,10-phenanthroline (OP)-induced apoptosis in murine tumor cells (Sun, Y., Bian, J., Wang, Y. and Jacobs, C. (1997) Oncogene 14, 385-393 [1]) [17].
  • The activity of the transcription factor NF-kappaB can be modulated by members of the Rho family of small GTPases (Perona, R., Montaner, S., Saniger, L., Sánchez-Pérez, I., Bravo, R., and Lacal, J. C. (1997) Genes Dev. 11, 463-475) [18].
  • A reaction scheme has been developed to model the sequence of steps necessary for the activation of RNase L (Cole, J. L., Carroll, S. S., Blue, E. S., Viscount, T., and Kuo, L. C. (1997) J. Biol. Chem. 272, 19187-19192) [19].
  • This study complements a previous investigation of the triad Asp122-Arg123-Tyr124 (Lu, Z-L., Curtis, C. A., Jones, P. G., Pavia, J., and Hulme, E. C. (1997) Mol. Pharmacol. 51, 234-241) [20].


  1. alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid. Li, Y.T., Wang, L.X., Pavlova, N.V., Li, S.C., Lee, Y.C. J. Biol. Chem. (1997) [Pubmed]
  2. Engineering of the protein environment around the redox-active TyrZ in photosystem II. The role of F186 and P162 in the D1 protein of Synechocystis 6803. Wiklund, R., Salih, G.F., Mäenpää, P., Jansson, C. Eur. J. Biochem. (2001) [Pubmed]
  3. Perception of motion trajectory of object from the moving cast shadow in infants. Imura, T., Yamaguchi, M.K., Kanazawa, S., Shirai, N., Otsuka, Y., Tomonaga, M., Yagi, A. Vision Res. (2006) [Pubmed]
  4. Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I. Han, J., Nicholson, A.C., Zhou, X., Feng, J., Gotto, A.M., Hajjar, D.P. J. Biol. Chem. (2001) [Pubmed]
  5. Phosphatidic acid regulates tyrosine phosphorylating activity in human neutrophils: enhancement of Fgr activity. Sergeant, S., Waite, K.A., Heravi, J., McPhail, L.C. J. Biol. Chem. (2001) [Pubmed]
  6. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. Stracke, J.O., Hutton, M., Stewart, M., Pendás, A.M., Smith, B., López-Otin, C., Murphy, G., Knäuper, V. J. Biol. Chem. (2000) [Pubmed]
  7. Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2. Walter, J., Schindzielorz, A., Hartung, B., Haass, C. J. Biol. Chem. (2000) [Pubmed]
  8. Cbfa1 isoforms exert functional differences in osteoblast differentiation. Harada, H., Tagashira, S., Fujiwara, M., Ogawa, S., Katsumata, T., Yamaguchi, A., Komori, T., Nakatsuka, M. J. Biol. Chem. (1999) [Pubmed]
  9. Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. Nishikawa, K., Toker, A., Wong, K., Marignani, P.A., Johannes, F.J., Cantley, L.C. J. Biol. Chem. (1998) [Pubmed]
  10. Site-directed mutagenesis of yeast eEF1A. Viable mutants with altered nucleotide specificity. Cavallius, J., Merrick, W.C. J. Biol. Chem. (1998) [Pubmed]
  11. Characterization of the high affinity cell-binding domain in the cell surface proteoglycan syndecan-4. McFall, A.J., Rapraeger, A.C. J. Biol. Chem. (1998) [Pubmed]
  12. Growth/cell cycle regulation of Sp1 phosphorylation. Black, A.R., Jensen, D., Lin, S.Y., Azizkhan, J.C. J. Biol. Chem. (1999) [Pubmed]
  13. Spectroscopically distinct cobalt(II) sites in heterodimetallic forms of the aminopeptidase from Aeromonas proteolytica: characterization of substrate binding. Bennett, B., Holz, R.C. Biochemistry (1997) [Pubmed]
  14. Bcl-XL cooperatively associates with the Bap31 complex in the endoplasmic reticulum, dependent on procaspase-8 and Ced-4 adaptor. Ng, F.W., Shore, G.C. J. Biol. Chem. (1998) [Pubmed]
  15. Activation of the cytochrome c gene by electrical stimulation in neonatal rat cardiac myocytes. Role of NRF-1 and c-Jun. Xia, Y., Buja, L.M., McMillin, J.B. J. Biol. Chem. (1998) [Pubmed]
  16. Subcellular locations of phosphatidylinositol 4-kinase isoforms. Wong, K., Meyers ddR, n.u.l.l., Cantley, L.C. J. Biol. Chem. (1997) [Pubmed]
  17. Induction of glutathione synthetase by 1,10-phenanthroline. Sun, Y. FEBS Lett. (1997) [Pubmed]
  18. Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors. Montaner, S., Perona, R., Saniger, L., Lacal, J.C. J. Biol. Chem. (1999) [Pubmed]
  19. Activation of RNase L by 2',5'-oligoadenylates. Kinetic characterization. Carroll, S.S., Cole, J.L., Viscount, T., Geib, J., Gehman, J., Kuo, L.C. J. Biol. Chem. (1997) [Pubmed]
  20. The functional topography of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor, revealed by scanning mutagenesis. Lu, Z.L., Hulme, E.C. J. Biol. Chem. (1999) [Pubmed]
WikiGenes - Universities