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Gene Review

Sdc4  -  syndecan 4

Mus musculus

Synonyms: AA959608, AW108331, Ryudocan core protein, SYND4, Synd4, ...
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Disease relevance of Sdc4

  • Cooperation of syndecan-2 and syndecan-4 among cell surface heparan sulfate proteoglycans in the actin cytoskeletal organization of Lewis lung carcinoma cells [1].
  • Role of Syndecan-4 in the cellular invasion of Orientia tsutsugamushi [2].
  • The provirus integration site was located 5.5 kb upstream of the first exon of the syndecan-4 gene, which encodes a heparan sulphate proteoglycan implicated in growth factor activation and protein kinase C distribution in focal adhesions [3].
  • Taken together, it is suggested that syndecan-4 is induced by hypoxia stimuli in ischemic heart tissues, and may function as a tissue-repair molecule via biological mediators such as heparin-binding growth factors [4].
  • In this study, we measured plasma levels of syndecan-4 in patients with acute myocardial infarction using an enzyme-immunoassay, and found that they were extremely high, with a peak of average (10.5 +/- 5.6 ng/ml, 2 weeks after onset), as compared with those in normal subjects (0.078 +/- 0.030 ng/ml) (p < 0.001) [4].

Psychiatry related information on Sdc4


High impact information on Sdc4


Biological context of Sdc4


Anatomical context of Sdc4


Associations of Sdc4 with chemical compounds


Physical interactions of Sdc4


Co-localisations of Sdc4

  • In quiescent cells, dynamin II is evenly distributed in the cytoplasm and colocalizes with syndecan-4 near the nucleus [19].

Regulatory relationships of Sdc4

  • Primary cardiac myocytes collected from the wild type C57/129 but not the homozygous TNF-alpha-/- knockout mice were able to induce syndecan-4 expression in ECV cells when cultured under hypoxic conditions [20].
  • Ultrasound exerts an influence downstream of syndecan-4 and PKCalpha to specifically activate Rac1, itself a critical regulator of tissue repair, and to a lesser extent RhoA [21].

Other interactions of Sdc4


Analytical, diagnostic and therapeutic context of Sdc4


  1. Cooperation of syndecan-2 and syndecan-4 among cell surface heparan sulfate proteoglycans in the actin cytoskeletal organization of Lewis lung carcinoma cells. Kusano, Y., Yoshitomi, Y., Munesue, S., Okayama, M., Oguri, K. J. Biochem. (2004) [Pubmed]
  2. Role of Syndecan-4 in the cellular invasion of Orientia tsutsugamushi. Kim, H.R., Choi, M.S., Kim, I.S. Microb. Pathog. (2004) [Pubmed]
  3. Infection of WHV/c-myc transgenic mice with Moloney murine leukaemia virus and proviral insertion near the syndecan-4 gene in an early liver tumour. Renard, C.A., Transy, C., Tiollais, P., Buendia, M.A. Res. Virol. (1998) [Pubmed]
  4. Plasma levels of syndecan-4 (ryudocan) are elevated in patients with acute myocardial infarction. Kojima, T., Takagi, A., Maeda, M., Segawa, T., Shimizu, A., Yamamoto, K., Matsushita, T., Saito, H. Thromb. Haemost. (2001) [Pubmed]
  5. Syndecan-4 as a molecule involved in defense mechanisms. Ishiguro, K., Kojima, T., Muramatsu, T. Glycoconj. J. (2002) [Pubmed]
  6. Syndecan-4 and focal adhesion function. Woods, A., Couchman, J.R. Curr. Opin. Cell Biol. (2001) [Pubmed]
  7. Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Cornelison, D.D., Wilcox-Adelman, S.A., Goetinck, P.F., Rauvala, H., Rapraeger, A.C., Olwin, B.B. Genes Dev. (2004) [Pubmed]
  8. Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. Echtermeyer, F., Streit, M., Wilcox-Adelman, S., Saoncella, S., Denhez, F., Detmar, M., Goetinck, P. J. Clin. Invest. (2001) [Pubmed]
  9. Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent manner. Saoncella, S., Calautti, E., Neveu, W., Goetinck, P.F. J. Biol. Chem. (2004) [Pubmed]
  10. Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. Gao, Y., Li, M., Chen, W., Simons, M. J. Cell. Physiol. (2000) [Pubmed]
  11. Syndecan-4 dependent FGF stimulation of mouse vibrissae growth. Iwabuchi, T., Goetinck, P.F. Mech. Dev. (2006) [Pubmed]
  12. Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family. Spring, J., Goldberger, O.A., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Bernfield, M. Genomics (1994) [Pubmed]
  13. Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Cornelison, D.D., Filla, M.S., Stanley, H.M., Rapraeger, A.C., Olwin, B.B. Dev. Biol. (2001) [Pubmed]
  14. Syndecan-4 expression is associated with follicular atresia in mouse ovary. Ishiguro, K., Kojima, T., Taguchi, O., Saito, H., Muramatsu, T., Kadomatsu, K. Histochem. Cell Biol. (1999) [Pubmed]
  15. Syndecan-4 modulates focal adhesion kinase phosphorylation. Wilcox-Adelman, S.A., Denhez, F., Goetinck, P.F. J. Biol. Chem. (2002) [Pubmed]
  16. Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor. Deepa, S.S., Yamada, S., Zako, M., Goldberger, O., Sugahara, K. J. Biol. Chem. (2004) [Pubmed]
  17. Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions. Ishiguro, K., Kadomatsu, K., Kojima, T., Muramatsu, H., Tsuzuki, S., Nakamura, E., Kusugami, K., Saito, H., Muramatsu, T. J. Biol. Chem. (2000) [Pubmed]
  18. Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice. Ishiguro, K., Kadomatsu, K., Kojima, T., Muramatsu, H., Iwase, M., Yoshikai, Y., Yanada, M., Yamamoto, K., Matsushita, T., Nishimura, M., Kusugami, K., Saito, H., Muramatsu, T. J. Biol. Chem. (2001) [Pubmed]
  19. Dynamin II interacts with syndecan-4, a regulator of focal adhesion and stress-fiber formation. Yoo, J., Jeong, M.J., Cho, H.J., Oh, E.S., Han, M.Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  20. Myocyte-dependent regulation of endothelial cell syndecan-4 expression. Role of TNF-alpha. Zhang, Y., Pasparakis, M., Kollias, G., Simons, M. J. Biol. Chem. (1999) [Pubmed]
  21. Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1. Mahoney, C.M., Morgan, M.R., Harrison, A., Humphries, M.J., Bass, M.D. J. Biol. Chem. (2009) [Pubmed]
  22. Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. Midwood, K.S., Valenick, L.V., Hsia, H.C., Schwarzbauer, J.E. Mol. Biol. Cell (2004) [Pubmed]
  23. Differential expression of glycosaminoglycans and proteoglycans in the migratory pathway of the primordial germ cells of the mouse. Soto-Suazo, M., San Martin, S., Ferro, E.S., Zorn, T.M. Histochem. Cell Biol. (2002) [Pubmed]
  24. Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation. Chung, J.S., Dougherty, I., Cruz, P.D., Ariizumi, K. J. Immunol. (2007) [Pubmed]
  25. Molecular cloning, genomic organization, promoter activity, and tissue-specific expression of the mouse ryudocan gene. Tsuzuki, S., Kojima, T., Katsumi, A., Yamazaki, T., Sugiura, I., Saito, H. J. Biochem. (1997) [Pubmed]
  26. Molecular cloning and expression of two distinct cDNA-encoding heparan sulfate proteoglycan core proteins from a rat endothelial cell line. Kojima, T., Shworak, N.W., Rosenberg, R.D. J. Biol. Chem. (1992) [Pubmed]
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