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Chemical Compound Review

Lanthanum-138     lanthanum

Synonyms: AC1L42WB, 138La, 15816-87-2, Lanthanum, isotope of mass 138
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Disease relevance of lanthanum


Psychiatry related information on lanthanum


High impact information on lanthanum

  • HERG current is K+ selective, declines with depolarizations above 0 mV, is activated by extracellular K+, and is blocked by lanthanum [9].
  • The channel is indistinguishable from ICRAC in the following features: sequence of selectivity to divalent cations; an anomalous mole fraction effect; whole-cell current kinetics; block by lanthanum; loss of selectivity in the absence of divalent cations; and single-channel conductance to Na+ in divalent-ion-free conditions [10].
  • In these experiments, up to 79% of the total tissue sialic acid was removed, and electron microscopy studies showed that this removal was accompanied by marked reduction of lanthanum binding to the sarcolemma [11].
  • Initiation of meiotic maturation in Xenopus laevis oocytes by lanthanum [12].
  • Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride [13].

Chemical compound and disease context of lanthanum

  • When mice were sensitized with dinitrofluorobenzene on skin sites pretreated with topical lanthanum chloride, and challenged on untreated ear skin, a markedly reduced contact hypersensitivity response was observed [14].
  • In a randomised 1-year trial, numerically fewer lanthanum carbonate (elemental lanthanum < or =3750 mg/day) recipients had renal bone disease at study end than at baseline; however, in the calcium carbonate < or =9000 mg/day group, numerically more patients had renal bone disease at study end compared with baseline [15].
  • The effects of lanthanum and gadolinium on currents evoked by excitatory amino acids were studied in cultured rat hippocampal and cortical neurons, in freshly dissociated dorsal root ganglion neurons, and in human embryonic kidney 293 cells expressing the GluR6 kainate receptor subunit [16].
  • 4. The blockade of the Na(+)-Ca2+ exchanger by the amiloride derivative 5-(N-4-chlorobenzyl)-2',4'-dimethylbenzamil (CB-DMB), lanthanum (La3+) and the Ca2+ chelator EGTA, completely reverted the protective effect exerted by the removal of Na+ ions on C6 glioma cells exposed to chemical hypoxia [17].
  • Low concentrations of lanthanum (0.1-0.5 mM) augmented the caffeine contracture [18].

Biological context of lanthanum


Anatomical context of lanthanum


Associations of lanthanum with other chemical compounds


Gene context of lanthanum

  • Protection of SH-SY5Y cells against MPP(+) was significantly decreased upon the overexpression of antisense TRPC1 cDNA construct or the addition of a nonspecific transient receptor potential channel blocker lanthanum [30].
  • Absence of a functional IL-10 gene in IL-10KO mice resulted in a significant augmentation of apical diffusion of lanthanum after DNBS-induced colitis [31].
  • Zinc-induced apoptosis was independent of inhibition of PKA, PKC, guanylate cyclase and MAPK, but it was suppressed in the presence of 100 microM lanthanum chloride [32].
  • Lanthanum (La3+) depresses IGFBP release from all three cell types (> 80% for GM10 and T98G cells and > 65% for MDBK cells) [33].
  • Furthermore, somatostatin enhanced the uptake of 45calcium in renal cortical slices which could be blocked by lanthanum, an inhibitor of Ca2+ influx [34].

Analytical, diagnostic and therapeutic context of lanthanum


  1. Lanthanum probe studies of cellular pathophysiology induced by hypoxia in isolated cardiac muscle. Burton, K.P., Hagler, H.K., Templeton, G.H., Willerson, J.T., Buja, L.M. J. Clin. Invest. (1977) [Pubmed]
  2. Suppression of experimental atherosclerosis by the Ca++-antagonist lanthanum. Possible role of calcium in atherogenesis. Kramsch, D.M., Aspen, A.J., Apstein, C.S. J. Clin. Invest. (1980) [Pubmed]
  3. Hepatocyte tight-junctional permeability is increased in rat experimental colitis. Lora, L., Mazzon, E., Martines, D., Fries, W., Muraca, M., Martin, A., d'Odorico, A., Naccarato, R., Citi, S. Gastroenterology (1997) [Pubmed]
  4. Lysosomes in myocardial infarction: studies by means of cytochemistry and subcellular fractionation, with observations on the effects of methylprednisolone. Hoffstein, S., Weissmann, G., Fox, A.C. Circulation (1976) [Pubmed]
  5. Junctional specialization in estrogen-induced renal adenocarcinomas of the golden hamster. Letourneau, R.J., Li, J.J., Rosen, S., Villee, C.A. Cancer Res. (1975) [Pubmed]
  6. The influence of calcium on short-term memory. Gibbs, M.E., Gibbs, C.L., Ng, K.T. Neurosci. Lett. (1979) [Pubmed]
  7. Effect of stress-related hormones on short term memory. Gibbs, M.E., De Vaus, J., Ng, K.T. Behav. Brain Res. (1986) [Pubmed]
  8. Effect of different factors modifying the activity of some enzyme systems of the endoplastic reticulum on the sensitivity of cell organelles against the damaging action of chemical agents. I: Interrelations between the activity of some enzyme systems located in endoplasmic reticulum and hepatotoxicity of carbon tetrachloride. Popov, C.S., Yantchev, I., Georgiev, G., Geneva, L. British journal of experimental pathology. (1976) [Pubmed]
  9. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Sanguinetti, M.C., Jiang, C., Curran, M.E., Keating, M.T. Cell (1995) [Pubmed]
  10. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Yue, L., Peng, J.B., Hediger, M.A., Clapham, D.E. Nature (2001) [Pubmed]
  11. Removal of sialic acid from cardiac sarcolemma does not affect contractile function in electrically stimulated guinea pig left atria. Harding, S.E., Halliday, J. Nature (1980) [Pubmed]
  12. Initiation of meiotic maturation in Xenopus laevis oocytes by lanthanum. Schorderet-Slatkine, S., Schorderet, M., Baulieu, E. Nature (1976) [Pubmed]
  13. Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. Boucek, M.M., Snyderman, R. Science (1976) [Pubmed]
  14. Inhibition of Langerhans cell ATPase and contact sensitization by lanthanides--role of T-suppressor cells. Gruner, S., Diezel, W., Strunk, D., Eckert, R., Siems, W., Anhalt, G.J. J. Invest. Dermatol. (1991) [Pubmed]
  15. Lanthanum carbonate. Swainston Harrison, T., Scott, L.J. Drugs (2004) [Pubmed]
  16. Antagonism of neuronal kainate receptors by lanthanum and gadolinium. Huettner, J.E., Stack, E., Wilding, T.J. Neuropharmacology (1998) [Pubmed]
  17. Pharmacological evidence that the activation of the Na(+)-Ca2+ exchanger protects C6 glioma cells during chemical hypoxia. Amoroso, S., De Maio, M., Russo, G.M., Catalano, A., Bassi, A., Montagnani, S., Renzo, G.D., Annunziato, L. Br. J. Pharmacol. (1997) [Pubmed]
  18. The effects of external potassium, multivalent cations and temperature on caffeine contractures in rat skeletal muscle. Anwyl, R., Bruton, J.D., McLoughlin, J.V. Br. J. Pharmacol. (1984) [Pubmed]
  19. Stimulation by leukotriene D4 of increases in the cytosolic concentration of calcium in dimethylsulfoxide-differentiated HL-60 cells. Baud, L., Goetzl, E.J., Koo, C.H. J. Clin. Invest. (1987) [Pubmed]
  20. Calcium restriction prolongs metaphase in dividing Tradescantia stamen hair cells. Hepler, P.K. J. Cell Biol. (1985) [Pubmed]
  21. Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. Witke, W., Li, W., Kwiatkowski, D.J., Southwick, F.S. J. Cell Biol. (2001) [Pubmed]
  22. Cold calcium signaling in Arabidopsis involves two cellular pools and a change in calcium signature after acclimation. Knight, H., Trewavas, A.J., Knight, M.R. Plant Cell (1996) [Pubmed]
  23. Bile formation in the rat: the role of the paracellular shunt pathway. Layden, T.J., Elias, E., Boyer, J.L. J. Clin. Invest. (1978) [Pubmed]
  24. Effects of aspirin on tight junction structure of the canine gastric mucosa. Meyer, R.A., McGinley, D., Posalaky, Z. Gastroenterology (1986) [Pubmed]
  25. Effects of anionic surfactants on hamster small intestinal membrane structure and function: relationship to surface activity. Gullikson, G.W., Cline, W.S., Lorenzsonn, V., Benz, L., Olsen, W.A., Bass, P. Gastroenterology (1977) [Pubmed]
  26. Glucose-induced alterations of cytosolic free calcium in cultured rat tail artery vascular smooth muscle cells. Barbagallo, M., Shan, J., Pang, P.K., Resnick, L.M. J. Clin. Invest. (1995) [Pubmed]
  27. Characterization of calcium uptake by brush border membrane vesicles of human small intestine. Ghishan, F.K., Arab, N., Nylander, W. Gastroenterology (1989) [Pubmed]
  28. Epithelial permeability and the transepithelial migration of human neutrophils. Milks, L.C., Brontoli, M.J., Cramer, E.B. J. Cell Biol. (1983) [Pubmed]
  29. Detection of the membrane-calcium distribution during mitosis in Haemanthus endosperm with chlorotetracycline. Wolniak, S.M., Hepler, P.K., Jackson, W.T. J. Cell Biol. (1980) [Pubmed]
  30. TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. Bollimuntha, S., Singh, B.B., Shavali, S., Sharma, S.K., Ebadi, M. J. Biol. Chem. (2005) [Pubmed]
  31. Role of IL-10 in hepatocyte tight junction alteration in mouse model of experimental colitis. Mazzon, E., Puzzolo, D., Caputi, A.P., Cuzzocrea, S. Mol. Med. (2002) [Pubmed]
  32. Induction of apoptosis in mammalian cells by cadmium and zinc. Wätjen, W., Haase, H., Biagioli, M., Beyersmann, D. Environ. Health Perspect. (2002) [Pubmed]
  33. Use of lanthanum to accurately quantify insulin-like growth factor binding to proteins on cell surfaces. McCusker, R.H., Clemmons, D.R. J. Cell. Biochem. (1997) [Pubmed]
  34. Somatostatin: a metabolic regulator. Dileepan, K.N., Wagle, S.R. Life Sci. (1985) [Pubmed]
  35. Calcium in epithelial cell contraction. Lee, H.C., Auersperg, N. J. Cell Biol. (1980) [Pubmed]
  36. Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells. Filip, D.A., Radu, A., Simionescu, M. Circ. Res. (1986) [Pubmed]
  37. Regulation of intercellular adhesion strength in fibroblasts. Chan, M.W., El Sayegh, T.Y., Arora, P.D., Laschinger, C.A., Overall, C.M., Morrison, C., McCulloch, C.A. J. Biol. Chem. (2004) [Pubmed]
  38. Does the phosphate binder lanthanum carbonate affect bone in rats with chronic renal failure? Behets, G.J., Dams, G., Vercauteren, S.R., Damment, S.J., Bouillon, R., De Broe, M.E., D'Haese, P.C. J. Am. Soc. Nephrol. (2004) [Pubmed]
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