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Chemical Compound Review

Lusmit     dodecyl3-(2- dodecoxycarbonylethylsulfanyl. ..

Synonyms: Dltdp, Dmptp, DLTP, Antioxidant AS, Milban F, ...
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Disease relevance of Plastanox LTDP


High impact information on Plastanox LTDP


Biological context of Plastanox LTDP

  • Furthermore, cDNAs of chaperonin, proteasome, antioxidant as well as genes associated with actin reorganization, which may be necessary for phagocytosis and encapsulation, were also expressed at a higher level after the challenge [11].
  • Furthermore, experiments showed a significant decrease in thymocytes apoptosis by antioxidant as measured by annexin-V labeling protocol [12].

Associations of Plastanox LTDP with other chemical compounds

  • Nitric oxide provides no direct protection against singlet oxygen exposure, but is an exceptional chain-breaking antioxidant as evident from its ability to blunt oxygen consumption during free radical-mediated lipid peroxidation [13].
  • However, none was nearly as potent an antioxidant as the clinical preparation of N-acetylcysteine, with an antioxidant activity of 502 mmol litre-1 [14].
  • Studies using reduced glutathione (GSH), the major pulmonary antioxidant, as a model therapeutic agent demonstrated that GSH can be administered directly to the respiratory epithelial surface by aerosol and is fully functional as an antioxidant both in vitro and in vivo [15].
  • The results indicate that MT works as an antioxidant as long as Zn is present in Cu-containing MT, while it works as a prooxidant when Zn is not present by liberating 1.5 M equivalents of cuprous ions relative to cupric ions added, and hydroxyl radicals are produced in the presence of hydrogen peroxide [16].
  • It was expected that the antioxidant and chelating properties of these functional groups combined with the basicity of the morpholine ring will impact on the antioxidant as well as on the partition and solubility characteristics of the compounds [17].

Gene context of Plastanox LTDP


  1. Pulmonary oxygen toxicity in mice is characterized by alterations in ascorbate redox status. Rusakow, L.S., Han, J., Hayward, M.A., Griffith, O.W. J. Appl. Physiol. (1995) [Pubmed]
  2. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication. Chayasirisobhon, S. Headache. (2006) [Pubmed]
  3. Photodynamic action of C-phycocyanins obtained from marine and fresh water cyanobacterial cultures: A comparative study using EPR spin trapping technique. Paul, B.T., Patel, A., Selvam, G.S., Mishra, S., Kumar Ghosh, P., Murugesan, R. Free Radic. Res. (2006) [Pubmed]
  4. Metallothionein protects against cerulein-induced acute pancreatitis: analysis using transgenic mice. Fu, K., Tomita, T., Sarras, M.P., De Lisle, R.C., Andrews, G.K. Pancreas (1998) [Pubmed]
  5. Fourteen week clinical evaluation of an oral antioxidant as a treatment for osteoarthritis secondary to canine hip dysplasia. Impellizeri, J.A., Lau, R.E., Azzara, F.A. The Veterinary quarterly. (1998) [Pubmed]
  6. Melatonin: from basic research to cancer treatment clinics. Vijayalaxmi, n.u.l.l., Thomas, C.R., Reiter, R.J., Herman, T.S. J. Clin. Oncol. (2002) [Pubmed]
  7. Inhibition of superoxide and ferritin-dependent lipid peroxidation by ceruloplasmin. Samokyszyn, V.M., Miller, D.M., Reif, D.W., Aust, S.D. J. Biol. Chem. (1989) [Pubmed]
  8. Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE. Yoshida, Y., Itoh, N., Hayakawa, M., Piga, R., Cynshi, O., Jishage, K., Niki, E. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  9. Diethyldithiocarbamate inhibits in vivo Cu,Zn-superoxide dismutase and perturbs free radical processes in the yeast Saccharomyces cerevisiae cells. Lushchak, V., Semchyshyn, H., Lushchak, O., Mandryk, S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  10. Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein. Hughes, M.A., Lee, C.W., Holm, C.F., Ghosh, S., Mills, A., Lockhart, L.A., Reed, S.L., Mann, B.J. Mol. Biochem. Parasitol. (2003) [Pubmed]
  11. Identification of genes involved in the response of haemocytes of Penaeus japonicus by suppression subtractive hybridization (SSH) following microbial challenge. He, N., Liu, H., Xu, X. Fish Shellfish Immunol. (2004) [Pubmed]
  12. Modification of thymocytes membrane radiooxidative damage and apoptosis by eugenol. Pandey, B.N., Mishra, K.P. J. Environ. Pathol. Toxicol. Oncol. (2004) [Pubmed]
  13. Comparing beta-carotene, vitamin E and nitric oxide as membrane antioxidants. Schafer, F.Q., Wang, H.P., Kelley, E.E., Cueno, K.L., Martin, S.M., Buettner, G.R. Biol. Chem. (2002) [Pubmed]
  14. Antioxidant potential of i.v. fluids. Stratford, N. British journal of anaesthesia. (1997) [Pubmed]
  15. Oxidant-protease interaction in the lung. Prospects for antioxidant therapy. Buhl, R., Meyer, A., Vogelmeier, C. Chest (1996) [Pubmed]
  16. Production of hydroxyl radicals by copper-containing metallothionein: roles as prooxidant. Suzuki, K.T., Rui, M., Ueda, J., Ozawa, T. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  17. Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants. Guillonneau, C., Charton, Y., Ginot, Y.M., Fouquier-d'Hérouël, M.V., Bertrand, M., Lockhart, B., Lestage, P., Goldstein, S. European journal of medicinal chemistry. (2003) [Pubmed]
  18. Apoptosis in adriamycin cardiomyopathy and its modulation by probucol. Kumar, D., Kirshenbaum, L.A., Li, T., Danelisen, I., Singal, P.K. Antioxid. Redox Signal. (2001) [Pubmed]
  19. Reduction of urinary thiols in nephrotic syndrome--a possible effect of free iron. Sinha, I., Ghosh, S., Dey, P., Jacob, J., Banerjee, D. Clin. Chim. Acta (2005) [Pubmed]
  20. Lipid peroxides and alpha-tocopherol in rat streptozotocin-induced diabetes mellitus. Higuchi, Y. Acta Med. Okayama (1982) [Pubmed]
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