Disease relevance of Plastanox LTDP

• We therefore investigated whether mice that suffer from oxygen toxicity show significant alterations in the redox status of ascorbate, an important antioxidant, as reflected by changes in the relative amounts of its oxidized and reduced forms [1].
• Further clinical investigation into the efficacy of antioxidant as therapy for chronic migraine is warranted [2].
• C-phycocyanins, major biliproteins of blue green algae (cyanobacteria), widely used as colourants in food and cosmetics are known for their antioxidant as well as therapeutic potential [3].
• These studies suggest that pancreatic MT can function as an intracellular antioxidant as does GSH and that these intracellular antioxidants play a protective role during cerulein-induced acute pancreatitis [4].
• Fourteen week clinical evaluation of an oral antioxidant as a treatment for osteoarthritis secondary to canine hip dysplasia [5].

High impact information on Plastanox LTDP

• Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger, an indirect antioxidant, as well as an important immunomodulatory agent [6].
• Ceruloplasmin failed to function as a peroxyl radical-scavenging antioxidant as evidenced by its inability to inhibit free radical-initiated peroxidation of linoleic acid, suggesting that CP inhibited lipid peroxidation by affecting the availability of ferritin-derived iron [7].
• Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE [8].
• Copper-zinc superoxide dismutase (Cu,Zn-SOD) and manganese superoxide dismutase (Mn-SOD) in some model experiments in vitro demonstrated antioxidant as well as pro-oxidant properties [9].
• Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein [10].

Biological context of Plastanox LTDP

• Furthermore, cDNAs of chaperonin, proteasome, antioxidant as well as genes associated with actin reorganization, which may be necessary for phagocytosis and encapsulation, were also expressed at a higher level after the challenge [11].
• Furthermore, experiments showed a significant decrease in thymocytes apoptosis by antioxidant as measured by annexin-V labeling protocol [12].

Associations of Plastanox LTDP with other chemical compounds

• Nitric oxide provides no direct protection against singlet oxygen exposure, but is an exceptional chain-breaking antioxidant as evident from its ability to blunt oxygen consumption during free radical-mediated lipid peroxidation [13].
• However, none was nearly as potent an antioxidant as the clinical preparation of N-acetylcysteine, with an antioxidant activity of 502 mmol litre-1 [14].
• Studies using reduced glutathione (GSH), the major pulmonary antioxidant, as a model therapeutic agent demonstrated that GSH can be administered directly to the respiratory epithelial surface by aerosol and is fully functional as an antioxidant both in vitro and in vivo [15].
• The results indicate that MT works as an antioxidant as long as Zn is present in Cu-containing MT, while it works as a prooxidant when Zn is not present by liberating 1.5 M equivalents of cuprous ions relative to cupric ions added, and hydroxyl radicals are produced in the presence of hydrogen peroxide [16].
• It was expected that the antioxidant and chelating properties of these functional groups combined with the basicity of the morpholine ring will impact on the antioxidant as well as on the partition and solubility characteristics of the compounds [17].

Gene context of Plastanox LTDP

• Probucol (cumulative dose, 120 mg/kg), a known antioxidant as well as promoter of endogenous antioxidants, significantly reduced the incidence of apoptosis as well as expression of Bax [18].
• BACKGROUND: Albumin is a potent antioxidant as it chelates transitional metals and contains antioxidants like thiol and bilirubin [19].
• On the basis of the present experiments, it was considered that the decrease of alpha-tocopherol might be due to consumption as an antioxidant as lipid peroxides increased in sera and livers [20].

References