Disease relevance of Copper alloy, Cu,Zn (U.S. Bronze B-124)

• Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis [1].
• Copper, zinc superoxide dismutase (SOD1 gene product) (superoxide:superoxide oxidoreductase, EC 1.15.1.1) is a copper-containing enzyme that functions to prevent oxygen toxicity [2].
• Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia [3].
• Copper, zinc, and iron were quantitated in the serum and lymphoid cells of the peripheral blood of healthy children and children with acute lymphocytic leukemia [4].
• Copper-zinc superoxide dismutase from Caulobacter crescentus CB15. A novel bacteriocuprein form of the enzyme [5].

High impact information on Copper alloy, Cu,Zn (U.S. Bronze B-124)

• Copper-zinc superoxide dismutase (CuZnSOD, SOD1 protein) is an abundant copper- and zinc-containing protein that is present in the cytosol, nucleus, peroxisomes, and mitochondrial intermembrane space of human cells [1].
• Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper [6].
• Copper/zinc superoxide dismutase activity in trisomy 21 by translocation [7].
• Copper, zinc, and iron in normal and leukemic lymphocytes from children [4].
• Copper/zinc superoxide dismutase (SOD1) is an abundant intracellular enzyme with an essential role in antioxidant defense [8].

Chemical compound and disease context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

• Copper-zinc superoxide dismutase activity did not change with heat stress or drug treatment, whereas manganese superoxide dismutase activity was increased in old animals only [9].

Biological context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

• Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice [10].
• Copper zinc superoxide dismutase (CuZnSOD) forms a crucial component of the cellular response to oxidative stress by catalyzing the dismutation of the superoxide radical to hydrogen peroxide and water [11].
• Copper/zinc superoxide dismutase and glutathione peroxidase gene expression remain at a normal level during progression of the model, whereas their activities show a temporary decrease in the early remnant kidney [12].
• Copper-zinc superoxide dismutase (CuZnSOD) is one of the proteins encoded by chromosome 21 (21q22.1) [13].
• Copper, zinc, and magnesium concentrations were high in sampled obtained during the first month of lactation [14].

Anatomical context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

• Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability [15].
• Copper-zinc superoxide dismutase (SOD-1) is an enzyme that is widely expressed in eukaryotic cells and performs a vital role in protecting cells against free radical damage [16].
• Copper-zinc superoxide dismutase was detected within some articular and epiphyseal chondrocytes of younger animals [17].
• Copper-zinc superoxide dismutase, glutathione peroxidase, and catalase in erythrocytes were unaltered [18].
• Copper, zinc, and magnesium content of breast milk of Indian women [19].

Associations of Copper alloy, Cu,Zn (U.S. Bronze B-124) with other chemical compounds

• Specifically, the Sf-9 insect cell line contained Manganese and Copper-Zinc superoxide dismutase (MnSOD and CuZnSOD) for reducing the superoxide radical (O(2)(*-)) to hydrogen peroxide (H(2)O(2)) and ascorbate peroxidase (APOX) for reducing the resulting H(2)O(2) to H(2)O [20].
• Copper-zinc containing and manganese containing superoxide dismutase in the ground squirrel/Citellus citellus/--the effect of hibernation [21].

Gene context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

• Copper zinc superoxide dismutase (CuZnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen in the cytoplasm [22].
• Copper-zinc SOD and glutathione peroxidase protein levels were low, whereas manganese SOD and catalase protein levels were high at E18 and P1 [23].
• Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice [24].
• Copper/zinc superoxide dismutase (SOD1) and manganese superoxide dismutase (SOD2) are the two major intracellular enzymes which inactivate superoxide radicals [25].
• Copper/zinc superoxide dismutase and glucose-6-phosphate dehydrogenase were similar in fetal and postnatal tissues and were unaltered appreciably by hyperoxic exposure [26].

Analytical, diagnostic and therapeutic context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

• Molecular cloning, characterization, and expression of a cDNA coding Copper/Zinc superoxide dismutase from black porgy [27].
• To our knowledge, there have been no previous reports regarding the immunohistochemistry and image cytometry to demonstrate elevated Copper/zinc superoxide dismutase (Cu/Zn SOD) expression and numbers of the clonal cells in human gliomas [28].
• Copper-zinc superoxide dismutase (Cu,Zn SOD) has been extracted, purified and characterized from Radix lethospermi seed (RLS), a kind of Chinese traditional medicine [29].
• Copper, zinc and magnesium concentrations in both plasma and erythrocytes were estimated before and after treatment [30].
• 1. Copper, zinc superoxide dismutase (Cu,Zn SOD) has been purified to homogeneity from chicken erythrocytes by anion-exchange, immobilized metal affinity and size exclusion chromatography [31].

References