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Chemical Compound Review

copper; zinc     copper; zinc

Synonyms: B-124, AC1L4JU8, 81219-95-6, Copper alloy, Cu,Zn (U.S. Bronze B-124)
 
 
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Disease relevance of Copper alloy, Cu,Zn (U.S. Bronze B-124)

 

High impact information on Copper alloy, Cu,Zn (U.S. Bronze B-124)

  • Copper-zinc superoxide dismutase (CuZnSOD, SOD1 protein) is an abundant copper- and zinc-containing protein that is present in the cytosol, nucleus, peroxisomes, and mitochondrial intermembrane space of human cells [1].
  • Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper [6].
  • Copper/zinc superoxide dismutase activity in trisomy 21 by translocation [7].
  • Copper, zinc, and iron in normal and leukemic lymphocytes from children [4].
  • Copper/zinc superoxide dismutase (SOD1) is an abundant intracellular enzyme with an essential role in antioxidant defense [8].
 

Chemical compound and disease context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

  • Copper-zinc superoxide dismutase activity did not change with heat stress or drug treatment, whereas manganese superoxide dismutase activity was increased in old animals only [9].
 

Biological context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

 

Anatomical context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

 

Associations of Copper alloy, Cu,Zn (U.S. Bronze B-124) with other chemical compounds

 

Gene context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

 

Analytical, diagnostic and therapeutic context of Copper alloy, Cu,Zn (U.S. Bronze B-124)

References

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  2. ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene. Gralla, E.B., Thiele, D.J., Silar, P., Valentine, J.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Fullerton, H.J., Ditelberg, J.S., Chen, S.F., Sarco, D.P., Chan, P.H., Epstein, C.J., Ferriero, D.M. Ann. Neurol. (1998) [Pubmed]
  4. Copper, zinc, and iron in normal and leukemic lymphocytes from children. Carpentieri, U., Myers, J., Thorpe, L., Daeschner, C.W., Haggard, M.E. Cancer Res. (1986) [Pubmed]
  5. Copper-zinc superoxide dismutase from Caulobacter crescentus CB15. A novel bacteriocuprein form of the enzyme. Steinman, H.M. J. Biol. Chem. (1982) [Pubmed]
  6. Structure and mechanism of copper, zinc superoxide dismutase. Tainer, J.A., Getzoff, E.D., Richardson, J.S., Richardson, D.C. Nature (1983) [Pubmed]
  7. Copper/zinc superoxide dismutase activity in trisomy 21 by translocation. Garber, P., Sinet, P.M., Jerome, H., Lejeune, J. Lancet (1979) [Pubmed]
  8. Mechanisms of biosynthesis of mammalian copper/zinc superoxide dismutase. Bartnikas, T.B., Gitlin, J.D. J. Biol. Chem. (2003) [Pubmed]
  9. Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress. Morrison, J.P., Coleman, M.C., Aunan, E.S., Walsh, S.A., Spitz, D.R., Kregel, K.C. J. Appl. Physiol. (2005) [Pubmed]
  10. Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Fujimura, M., Morita-Fujimura, Y., Narasimhan, P., Copin, J.C., Kawase, M., Chan, P.H. Stroke (1999) [Pubmed]
  11. Structure of fully reduced bovine copper zinc superoxide dismutase at 1.15 A. Hough, M.A., Hasnain, S.S. Structure (Camb.) (2003) [Pubmed]
  12. Antioxidant enzyme gene expression in rats with remnant kidney induced chronic renal failure. Van Den Branden, C., Ceyssens, B., De Craemer, D., De Bleser, P., Hellemans, K., Geerts, A., Verbeelen, D. Exp. Nephrol. (2000) [Pubmed]
  13. Overexpression of copper-zinc superoxide dismutase in trisomy 21. De La Torre, R., Casado, A., López-Fernández, E., Carrascosa, D., Ramírez, V., Sáez, J. Experientia (1996) [Pubmed]
  14. Lipid and trace element composition of human milk. Belavady, B. Acta paediatrica Scandinavica. (1978) [Pubmed]
  15. Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability. Bergeron, C., Petrunka, C., Weyer, L. Am. J. Pathol. (1996) [Pubmed]
  16. In male mouse germ cells, copper-zinc superoxide dismutase utilizes alternative promoters that produce multiple transcripts with different translation potential. Gu, W., Morales, C., Hecht, N.B. J. Biol. Chem. (1995) [Pubmed]
  17. Immunohistochemical identification of superoxide dismutases, catalase, and glutathione-S-transferases in rat femora. Deahl, S.T., Oberley, L.W., Oberley, T.D., Elwell, J.H. J. Bone Miner. Res. (1992) [Pubmed]
  18. Antioxidant enzymes and lipoperoxide in blood in uremic children and adolescents. Asayama, K., Shiki, Y., Ito, H., Hasegawa, O., Miyao, A., Hayashibe, H., Dobashi, K., Kato, K. Free Radic. Biol. Med. (1990) [Pubmed]
  19. Copper, zinc, and magnesium content of breast milk of Indian women. Rajalakshmi, K., Srikantia, S.G. Am. J. Clin. Nutr. (1980) [Pubmed]
  20. Antioxidant defense systems of two lipidopteran insect cell lines. Wang, Y., Oberley, L.W., Murhammer, D.W. Free Radic. Biol. Med. (2001) [Pubmed]
  21. Copper-zinc containing and manganese containing superoxide dismutase in the ground squirrel/Citellus citellus/--the effect of hibernation. Petrović, V.M., Milić, B., Spasić, M., Saicić, Z. Free Radic. Res. Commun. (1986) [Pubmed]
  22. Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. Zhang, Y., Zhao, W., Zhang, H.J., Domann, F.E., Oberley, L.W. Cancer Res. (2002) [Pubmed]
  23. Developmental changes in murine brain antioxidant enzymes. Khan, J.Y., Black, S.M. Pediatr. Res. (2003) [Pubmed]
  24. Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. Noshita, N., Sugawara, T., Hayashi, T., Lewén, A., Omar, G., Chan, P.H. J. Neurosci. (2002) [Pubmed]
  25. Ovarian function in superoxide dismutase 1 and 2 knockout mice. Matzuk, M.M., Dionne, L., Guo, Q., Kumar, T.R., Lebovitz, R.M. Endocrinology (1998) [Pubmed]
  26. Effects of ambient oxygen concentration on the growth and antioxidant defenses of of human cell cultures established from fetal and postnatal skin. Balin, A.K., Pratt, L., Allen, R.G. Free Radic. Biol. Med. (2002) [Pubmed]
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  29. Purification and some properties of Cu,Zn superoxide dismutase from Radix lethospermi seed, kind of Chinese traditional medicine. Haddad, N.I., Yuan, Q. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2005) [Pubmed]
  30. Trace element status in plasma and erythrocytes in hyperemesis gravidarum. Dökmeci, F., Engin-Ustün, Y., Ustün, Y., Kavas, G.O., Kocatürk, P.A. The Journal of reproductive medicine. (2004) [Pubmed]
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