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Gene Review

Anxa5  -  annexin A5

Mus musculus

Synonyms: Anchorin CII, Annexin A5, Annexin V, Annexin-5, Anx5, ...
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Disease relevance of Anxa5

  • Mouse annexin V genomic organization includes an endogenous retrovirus [1].
  • Effects of Phytolacca acinosa polysaccharides I (PAP-I), 5 approximately 40 mg/kg in timing of 7 times/wk, 3 times/wk and 1 time/wk on their antitumor efficiency in Sarcoma-180 bearing mice were comparatively investigated [2].
  • Here, we report that AxV preferentially targets irradiated lymphoma cells to CD8+ dendritic cells for in vivo clearance, elicits the release of proinflammatory cytokines and dramatically enhances the protection elicited against the tumor [3].
  • The in vivo antithrombotic activities of the most active constructs were 3- to 10-fold higher than that of ANV in a mouse arterial thrombosis model [4].
  • Previously, we have found that human liver annexin V (hA-V; in earlier reports referred as Endonexin II) is a specific hepatitis B surface antigen (HBsAg) binding protein [5].

Psychiatry related information on Anxa5

  • The numbers in thymocytes, especially CD4(+)CD8(+) population, were decreased significantly and apoptotic cells, as assessed by Annexin V expression, were reciprocally increased after the exposure to the psychological stress [6].

High impact information on Anxa5


Chemical compound and disease context of Anxa5


Biological context of Anxa5

  • Therefore, expression of the Anxa5 gene may represent a novel marker characterizing cell lineages involved in the development of the vascular as well as the skeletal system [15].
  • When anxA5 binds to the PtdSer-expressing membranes during apoptosis, it crystallizes as an extended two-dimensional network and activates thereby a novel portal of cell entry that results in the internalization of the PtdSer-expressing membrane patches [16].
  • This down-regulation depends on the abilities of anxA5 to bind to PtdSer and to form a two-dimensional crystal at the membrane [16].
  • The intensively studied annexin A5 has been identified by its effects on blood coagulation, and subsequently, its function as a calcium-specific ion channel was described [17].
  • Myotube formation in vitro can be inhibited by the PS binding protein annexin V, in contrast to its mutant M1234, which lacks the ability to bind to PS [18].

Anatomical context of Anxa5


Associations of Anxa5 with chemical compounds


Physical interactions of Anxa5


Regulatory relationships of Anxa5


Other interactions of Anxa5

  • We furthermore show that THP-1 cells produce and externalize anxA5 that cause the internalization of TF in an autocrine type of mechanism [16].
  • Fas expression and apoptosis were determined by FACScan analysis of phycoerythrin-anti-Fas mAb staining and annexin V staining, respectively [35].
  • LPS-induced cytotoxicity, poly(ADP-ribose) polymerase cleavage, and annexin V staining were also highest in p60-/- p80-/- cells and lowest in wt cells [36].
  • Further studies on IL-1, TNF and IL-6 secreted from macrophages and the level of CSF activity in serum of normal mice with different schedules showed that PAP-I (10 mg/kg, 3 time/wk) was the best one in regulating the production of IL-1, TNF, IL-6 and CSF activity [2].
  • A variety of assays were used to assess the progression of apoptosis: DNA size analysis on agarose gel electrophoresis, flow cytometry with annexin V/PI staining, and analysis of expression levels of Bcl-2 family and NF-kappaB mRNA and proteins by RT-PCR, Western blotting, and EMSA [37].

Analytical, diagnostic and therapeutic context of Anxa5


  1. Mouse annexin V genomic organization includes an endogenous retrovirus. Rodriguez-Garcia, M.I., Morgan, R.O., Fernandez, M.R., Bances, P., Fernandez, M.P. Biochem. J. (1999) [Pubmed]
  2. Effects of Phytolacca acinosa polysaccharides I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1, IL-2, IL-6, TNF, CSF activity in normal mice. Wang, H.B., Zheng, Q.Y. Immunopharmacology and immunotoxicology. (1997) [Pubmed]
  3. Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. Bondanza, A., Zimmermann, V.S., Rovere-Querini, P., Turnay, J., Dumitriu, I.E., Stach, C.M., Voll, R.E., Gaipl, U.S., Bertling, W., Pöschl, E., Kalden, J.R., Manfredi, A.A., Herrmann, M. J. Exp. Med. (2004) [Pubmed]
  4. Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants. Chen, H.H., Vicente, C.P., He, L., Tollefsen, D.M., Wun, T.C. Blood (2005) [Pubmed]
  5. Transfection of a rat hepatoma cell line with a construct expressing human liver annexin V confers susceptibility to hepatitis B virus infection. Gong, Z.J., De Meyer, S., van Pelt, J., Hertogs, K., Depla, E., Soumillion, A., Fevery, J., Yap, S.H. Hepatology (1999) [Pubmed]
  6. Chlorella vulgaris culture supernatant (CVS) reduces psychological stress-induced apoptosis in thymocytes of mice. Hasegawa, T., Noda, K., Kumamoto, S., Ando, Y., Yamada, A., Yoshikai, Y. Int. J. Immunopharmacol. (2000) [Pubmed]
  7. Real-time imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart. Dumont, E.A., Reutelingsperger, C.P., Smits, J.F., Daemen, M.J., Doevendans, P.A., Wellens, H.J., Hofstra, L. Nat. Med. (2001) [Pubmed]
  8. Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs. Wang, X.Z., Stepp, S.E., Brehm, M.A., Chen, H.D., Selin, L.K., Welsh, R.M. Immunity (2003) [Pubmed]
  9. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. Gebuhr, T.C., Kovalev, G.I., Bultman, S., Godfrey, V., Su, L., Magnuson, T. J. Exp. Med. (2003) [Pubmed]
  10. Annexin V delays apoptosis while exerting an external constraint preventing the release of CD4+ and PrPc+ membrane particles in a human T lymphocyte model. Gidon-Jeangirard, C., Hugel, B., Holl, V., Toti, F., Laplanche, J.L., Meyer, D., Freyssinet, J.M. J. Immunol. (1999) [Pubmed]
  11. The influence on the immunomodulatory effects of dying and dead cells of Annexin V. Munoz, L.E., Franz, S., Pausch, F., F??rnrohr, B., Sheriff, A., Vogt, B., Kern, P.M., Baum, W., Stach, C., von Laer, D., Brachvogel, B., Poschl, E., Herrmann, M., Gaipl, U.S. J. Leukoc. Biol. (2007) [Pubmed]
  12. Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3beta and transcription factor beta-catenin. Bergmann, M.W., Rechner, C., Freund, C., Baurand, A., El Jamali, A., Dietz, R. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  13. In vivo detection of apoptotic cells in the testis using fluorescence labeled annexin V in a mouse model of testicular torsion. Yang, S.K., Attipoe, S., Klausner, A.P., Tian, R., Pan, D., Rich, T.A., Turner, T.T., Steers, W.D., Lysiak, J.J. J. Urol. (2006) [Pubmed]
  14. Influence of beta-adrenoceptor antagonists on hemorrhage-induced cellular immune suppression. Oberbeck, R., van Griensven, M., Nickel, E., Tschernig, T., Wittwer, T., Pape, H.C. Shock (2002) [Pubmed]
  15. Sequential expression of annexin A5 in the vasculature and skeletal elements during mouse development. Brachvogel, B., Welzel, H., Moch, H., von der Mark, K., Hofmann, C., Pöschl, E. Mech. Dev. (2001) [Pubmed]
  16. Annexin A5 down-regulates surface expression of tissue factor: a novel mechanism of regulating the membrane receptor repertoir. Ravassa, S., Bennaghmouch, A., Kenis, H., Lindhout, T., Hackeng, T., Narula, J., Hofstra, L., Reutelingsperger, C. J. Biol. Chem. (2005) [Pubmed]
  17. Annexin A5 is not essential for skeletal development. Brachvogel, B., Dikschas, J., Moch, H., Welzel, H., von der Mark, K., Hofmann, C., Pöschl, E. Mol. Cell. Biol. (2003) [Pubmed]
  18. Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation. van den Eijnde, S.M., van den Hoff, M.J., Reutelingsperger, C.P., van Heerde, W.L., Henfling, M.E., Vermeij-Keers, C., Schutte, B., Borgers, M., Ramaekers, F.C. J. Cell. Sci. (2001) [Pubmed]
  19. Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation. Wilson, H.L., Francis, S.E., Dower, S.K., Crossman, D.C. J. Immunol. (2004) [Pubmed]
  20. Lymph node cells from BALB/c mice with chronic visceral leishmaniasis exhibiting cellular anergy and apoptosis: Involvement of Ser/Thr phosphatase. Mukherjee, P., Sen, P.C., Ghose, A.C. Apoptosis (2006) [Pubmed]
  21. Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes. Chen, L., Brosnan, C.F. J. Immunol. (2006) [Pubmed]
  22. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. Alpdogan, O., Muriglan, S.J., Eng, J.M., Willis, L.M., Greenberg, A.S., Kappel, B.J., van den Brink, M.R. J. Clin. Invest. (2003) [Pubmed]
  23. Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity. Merchant, M.S., Woo, C.W., Mackall, C.L., Thiele, C.J. J. Natl. Cancer Inst. (2002) [Pubmed]
  24. Multiple forms of angiostatin induce apoptosis in endothelial cells. Lucas, R., Holmgren, L., Garcia, I., Jimenez, B., Mandriota, S.J., Borlat, F., Sim, B.K., Wu, Z., Grau, G.E., Shing, Y., Soff, G.A., Bouck, N., Pepper, M.S. Blood (1998) [Pubmed]
  25. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Shui, J.W., Hu, M.C., Tan, T.H. Mol. Cell. Biol. (2007) [Pubmed]
  26. Cutting edge: Ly49A inhibits TCR/CD3-induced apoptosis and IL-2 secretion. Roger, J., Chalifour, A., Lemieux, S., Duplay, P. J. Immunol. (2001) [Pubmed]
  27. Modulation of O-glycans and N-glycans on murine CD8 T cells fails to alter annexin V ligand induction by galectin 1. Carlow, D.A., Williams, M.J., Ziltener, H.J. J. Immunol. (2003) [Pubmed]
  28. CD4(+) T-cell-mediated mechanisms of corneal allograft rejection: role of Fas-induced apoptosis. Hegde, S., Beauregard, C., Mayhew, E., Niederkorn, J.Y. Transplantation (2005) [Pubmed]
  29. HPMA copolymers containing doxorubicin bound by a proteolytically or hydrolytically cleavable bond: comparison of biological properties in vitro. Kovár, M., Kovár, L., Subr, V., Etrych, T., Ulbrich, K., Mrkvan, T., Loucká, J., Ríhová, B. Journal of controlled release : official journal of the Controlled Release Society. (2004) [Pubmed]
  30. Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Leo, L., Di Paola, J., Judd, B.A., Koretzky, G.A., Lentz, S.R. Blood (2002) [Pubmed]
  31. Effects of Phytolacca acinosa polysaccharides I on immune function in mice. Wang, H.B., Zheng, Q.Y., Qian, D.H., Fang, J., Ju, D.W. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1993) [Pubmed]
  32. Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. Komatsu, K., Buchanan, F.G., Katkuri, S., Morrow, J.D., Inoue, H., Otaka, M., Watanabe, S., DuBois, R.N. Gastroenterology (2005) [Pubmed]
  33. Fas-mediated cholangiopathy in the murine model of graft versus host disease. Ueno, Y., Ishii, M., Yahagi, K., Mano, Y., Kisara, N., Nakamura, N., Shimosegawa, T., Toyota, T., Nagata, S. Hepatology (2000) [Pubmed]
  34. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Sattler, M., Pride, Y.B., Ma, P., Gramlich, J.L., Chu, S.C., Quinnan, L.A., Shirazian, S., Liang, C., Podar, K., Christensen, J.G., Salgia, R. Cancer Res. (2003) [Pubmed]
  35. IL-10 protects mouse intestinal epithelial cells from Fas-induced apoptosis via modulating Fas expression and altering caspase-8 and FLIP expression. Bharhani, M.S., Borojevic, R., Basak, S., Ho, E., Zhou, P., Croitoru, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  36. Genetic deletion of the tumor necrosis factor receptor p60 or p80 sensitizes macrophages to lipopolysaccharide-induced nuclear factor-kappa B, mitogen-activated protein kinases, and apoptosis. Takada, Y., Aggarwal, B.B. J. Biol. Chem. (2003) [Pubmed]
  37. Toxoplasma gondii Inhibits Apoptosis in Infected Cells by Caspase Inactivation and NF-kappaB Activation. Kim, J.Y., Ahn, M.H., Jun, H.S., Jung, J.W., Ryu, J.S., Min, D.Y. Yonsei Med. J. (2006) [Pubmed]
  38. IL-2-mediated apoptosis of kidney tubular epithelial cells is regulated by the caspase-8 inhibitor c-FLIP. Du, C., Guan, Q., Yin, Z., Zhong, R., Jevnikar, A.M. Kidney Int. (2005) [Pubmed]
  39. Influence of cadmium on murine thymocytes: potentiation of apoptosis and oxidative stress. Pathak, N., Khandelwal, S. Toxicol. Lett. (2006) [Pubmed]
  40. Effects of Phytolacca acinosa polysaccharides I combined with interleukin-2 on the cytotoxicity of murine splenocytes against tumor cells. Wang, H.B., Chen, W.Z., Bao, E.J., Zheng, Q.Y., Song, H.L., Fang, J., Xu, Y.X., Chen, H.S. Yao Xue Xue Bao (1995) [Pubmed]
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