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Chemical Compound Review

CHEMBL136496     1,2,3,4-tetrachloro-5-(3,4...

Synonyms: AG-F-35342, PCB 156, AC1L1YWN, LS-44411, CTK4H9867, ...
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Disease relevance of CB 156


High impact information on CB 156


Biological context of CB 156


Anatomical context of CB 156


Gene context of CB 156

  • At an estimated daily intake of 81 micrograms PCB 156/kg body wt/day CYP1A1 and CYP1A2 activities were induced [1].
  • Aroclor formulations and their subsequent usage are considered to be the most important sources in terms of human exposure to some TEF-rated congeners, notably PCB-118, PCB-156 and part of PCB-126 [9].

Analytical, diagnostic and therapeutic context of CB 156


  1. Toxic potency of 2,3,3',4,4',5-hexachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat. Van Birgelen, A.P., Van der Kolk, J., Fase, K.M., Bol, I., Poiger, H., Van den Berg, M., Brouwer, A. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  2. Relationship between Ah receptor-mediated polychlorinated biphenyl (PCB)-induced humoral immunosuppression and thymic atrophy. Silkworth, J.B., Antrim, L. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  3. Promotion of enzyme altered foci in female rat 2,3,3',4,4',5-hexachlorobiphenyl. Haag-Grönlund, M., Kato, Y., Fransson-Steen, R., Scheu, G., Wärngârd, L. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  4. Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment. Van Birgelen, A.P., Smit, E.A., Kampen, I.M., Groeneveld, C.N., Fase, K.M., Van der Kolk, J., Poiger, H., Van den Berg, M., Koeman, J.H., Brouwer, A. Eur. J. Pharmacol. (1995) [Pubmed]
  5. Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. Peters, A.K., Leonards, P.E., Zhao, B., Bergman, A., Denison, M.S., Van den Berg, M. Toxicol. Lett. (2006) [Pubmed]
  6. Uptake and distribution of three PCB congeners and endosulfan by developing white leghorn chicken embryos (Gallus domesticus). Bargar, T.A., Scott, G.I., Cobb, G.P. Arch. Environ. Contam. Toxicol. (2001) [Pubmed]
  7. Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity. Parkinson, A., Cockerline, R., Safe, S. Chem. Biol. Interact. (1980) [Pubmed]
  8. Proliferative responses of harbor seal (Phoca vitulina) T lymphocytes to model marine pollutants. Neale, J.C., van de Water, J.A., Harvey, J.T., Tjeerdema, R.S., Gershwin, M.E. Dev. Immunol. (2002) [Pubmed]
  9. Dioxin-like PCBs in the environment-human exposure and the significance of sources. Alcock, R.E., Behnisch, P.A., Jones, K.C., Hagenmaier, H. Chemosphere (1998) [Pubmed]
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