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High impact information on Apocynaceae

  • Actinophyllic acid, a potent indole alkaloid inhibitor of the coupled enzyme assay carboxypeptidase u/hippuricase from the leaves of Alstonia actinophylla (Apocynaceae) [1].
  • Gastroprotective mechanisms of indole alkaloids from Himatanthus lancifolius [2].
  • The indole alkaloids mixture (AlkF) obtained from the barks of Himatanthus lancifolius (Muell. Arg.) Woodson was evaluated for gastroprotective properties in rodents [2].
  • The optimized HPLC system was applied for the separation of 23 standard indole alkaloids as well as for qualitative and quantitative analyses of crude alkaloid extracts of Rauvolfia serpentina X Rhazya stricta hybrid cell cultures [3].
  • The latex from Himatanthus sucuuba is used in popular amazonian medicine as an anti-inflammatory remedy [4].

Biological context of Apocynaceae

  • Rhazimine from Rhazya stricta: a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation [5].
  • The enzymatic properties of Plumeria rubra latex have been evaluated for the first time, showing a high activity in both hydrolysis and synthesis reactions, and compared to the biocatalytic behavior of babaco (Vasconcellea x Heilbornii cv.) latex [6].
  • In synthesis reactions (esterification, alcoholysis, and interesterification) biocatalyzed by Plumeria latex, correlation between best reaction yields and water activity cannot be done [6].
  • A cysteine protease, with a high cysteine content and a high degree of amino terminal sequence homology with ervatamins B and C, has been purified from the latex of Ervatamia heyneana (Family Apocynaceae) [7].
  • The effects of a leaf extract of the traditional medicinal plant Rhazya stricta (0.25, 1.0 and 4.0 g/kg/day for 3 days) on reduced glutathione (GSH), lipid peroxidation (LP) and ascorbic acid (AA) concentrations in the liver and kidneys were studied in rats 24 h after the last dose [8].

Anatomical context of Apocynaceae

  • This study reveals that the bark of Himatanthus lancifolius possesses one or more indole alkaloids able to alter non-vascular and vascular smooth muscle responsiveness, an event that may involve the blocking of calcium entry or changes on intracellular calcium utilization or mobilization [9].

Associations of Apocynaceae with chemical compounds


Gene context of Apocynaceae


  1. Actinophyllic acid, a potent indole alkaloid inhibitor of the coupled enzyme assay carboxypeptidase u/hippuricase from the leaves of Alstonia actinophylla (Apocynaceae). Carroll, A.R., Hyde, E., Smith, J., Quinn, R.J., Guymer, G., Forster, P.I. J. Org. Chem. (2005) [Pubmed]
  2. Gastroprotective mechanisms of indole alkaloids from Himatanthus lancifolius. Baggio, C.H., De Martini Otofuji, G., de Souza, W.M., de Moraes Santos, C.A., Torres, L.M., Rieck, L., de Andrade Marques, M.C., Mesia-Vela, S. Planta Med. (2005) [Pubmed]
  3. High-performance liquid chromatographic, capillary electrophoretic and capillary electrophoretic-electrospray ionisation mass spectrometric analysis of selected alkaloid groups. Stöckigt, J., Sheludk, Y., Unger, M., Gerasimenko, I., Warzecha, H., Stöckigt, D. Journal of chromatography. A. (2002) [Pubmed]
  4. Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba. de Miranda, A.L., Silva, J.R., Rezende, C.M., Neves, J.S., Parrini, S.C., Pinheiro, M.L., Cordeiro, M.C., Tamborini, E., Pinto, A.C. Planta Med. (2000) [Pubmed]
  5. Rhazimine from Rhazya stricta: a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. Saeed, S.A., Simjee, R.U., Mahmood, F., Sultana, N., Atta-ur-Rahman, n.u.l.l. Planta Med. (1993) [Pubmed]
  6. Comparison of the lipase activity in hydrolysis and acyl transfer reactions of two latex plant extracts from babaco (Vasconcellea x Heilbornii Cv.) and Plumeria rubra: Effect of the Aqueous microenvironment. Cambon, E., Gouzou, F., Pina, M., Barea, B., Barouh, N., Lago, R., Ruales, J., Tsai, S.W., Villeneuve, P. J. Agric. Food Chem. (2006) [Pubmed]
  7. A high cysteine containing thiol proteinase from the latex of Ervatamia heyneana: purification and comparison with ervatamin B and C from Ervatamia coronaria. Patel, B.K., Jagannadham, M.V. J. Agric. Food Chem. (2003) [Pubmed]
  8. Antioxidant action of extract of the traditional medicinal plant Rhazya stricta Decne. in rats. Ali, B.H., Alqarawi, A.A., Bashir, A.K., Tanira, M.O. Phytotherapy research : PTR. (2000) [Pubmed]
  9. Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsiveness. Rattmann, Y.D., Terluk, M.R., Souza, W.M., Santos, C.A., Biavatti, M.W., Torres, L.B., Mesia-Vela, S., Rieck, L., da Silva-Santos, J.E., Marques, M.C. Journal of ethnopharmacology. (2005) [Pubmed]
  10. Chonemorphine, stigmasterol, and ecdysterone: steroids isolated through bioassay-directed plant screening programs. Shah, V.C., D'Sa, A.S., de Souza, N.J. Steroids (1989) [Pubmed]
  11. South American plants III: Isolation of fulvoplumierin from Himatanthus sucuuba (M. Arg.) Woodson (Apocynaceae). Perdue, G.P., Blomster, R.N. Journal of pharmaceutical sciences. (1978) [Pubmed]
  12. Chemical constituents of Echites hirsuta (Apocynaceae). Chien, M.M., Svoboda, G.H., Schiff, P.L., Slatkin, D.J., Knapp, J.E. Journal of pharmaceutical sciences. (1979) [Pubmed]
  13. Antimutagens from Plumeria acuminata Ait. Guevara, A.P., Amor, E., Russell, G. Mutat. Res. (1996) [Pubmed]
  14. Inhibition of serine proteases by anti-inflammatory triterpenoids. Rajic, A., Kweifio-Okai, G., Macrides, T., Sandeman, R.M., Chandler, D.S., Polya, G.M. Planta Med. (2000) [Pubmed]
  15. Confluentic acid and 2'-O-methylperlatolic acid, monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba. Endo, Y., Hayashi, H., Sato, T., Maruno, M., Ohta, T., Nozoe, S. Chem. Pharm. Bull. (1994) [Pubmed]
  16. The effect on plasma glucose, insulin and glucagon levels of treatment of diabetic rats with the medicinal plant Rhazya stricta and with glibenclamide, alone and in combination. Ali, B.H. J. Pharm. Pharmacol. (1997) [Pubmed]
  17. Isolation of opioid-active compounds from Tabernaemontana pachysiphon leaves. Ingkaninan, K., Ijzerman, A.P., Taesotikult, T., Verpoorte, R. J. Pharm. Pharmacol. (1999) [Pubmed]
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