Disease relevance of EINECS 247-991-8

• The effect of octadecenoic acid on the growth of japanese encephalitis virus in Novikoff hepatoma cells [1].
• The fatty acid profiles of the three Rochalimaea strains were similar, with octadecenoic acid (C18:1) the most abundant, followed by octadecanoic (C18:0) and hexadecanoic (C16:0) acids [2].
• The cellular fatty acid compositions were determined for 42 strains of Pseudomonas cepacia from five cystic fibrosis centers in North America. All isolates contained significant (20%) amounts of hexadecanoic (C16:0), and cis-9 hexadecenoic (C16:1 cis9) acids and an isomer of octadecenoic acid (C18:1) [3].
• These results showed that octadecenoic acid and trans FAs had strong promotion activities for the Lactobacillus growth due to their incorporation into membrane lipids [4].
• The origin and metabolism of octadecenoic acid (18 : 1) was examined in intact Novikoff rat hepatoma cells by using labeled precursors and two isomeric octadecenoic acids which differed in their abilities to stimulate cell growth in a serum-free medium [5].

High impact information on EINECS 247-991-8

• BACKGROUND: Vaccenic acid (11-trans octadecenoic acid; VA), a major trans fatty acid in the fat of ruminants, is produced in the rumen and converted in tissues to rumenic acid (9-cis, 11-trans octadecenoic acid; RA), an isomer of conjugated linoleic acid, by Delta(9)-desaturase [6].
• Trans isomers of octadecenoic acid had catabolic effects on adipocyte metabolism that occurred regardless of the position of the double bond, the fatty acid concentration in media or the fatty acid to albumin ratio [7].
• In accordance with the induction of stearoyl-CoA desaturase, the increase in the proportion of octadecenoic acid in hepatic lipid lasted throughout the 22-week treatment [8].
• Certain isomers of octadecenoic acid (i.e., cis-9) and eicosatrienoic acid (i.e.,cis-8,11,14) permitted continued replication of mitochondria and provided cultures that contained only 4 to 5% cells that formed petite colonies [9].
• Identification of the trans isomers of octadecenoic acid in human milk [10].

Chemical compound and disease context of EINECS 247-991-8

• The sources of octadecenoic acid (18:1) and the importance of the stearoyl-CoA desaturase system in maintaining elevated levels of this fatty acid in the Morris hepatoma 7288C have been investigated [11].

Biological context of EINECS 247-991-8

• Replacing cis octadecenoic acid with trans isomers in media containing rat adipocytes stimulates lipolysis and inhibits glucose utilization [7].
• Thus, both the location of the double bond in the acyl-chain and the geometrical configuration specifically influence the rate of oxidation and esterification of octadecenoic acid in perfused rat liver [12].
• The hydrogenation of a range of double-bond positional and configurational octadecenoic acid isomers (cis (delta 2 and delta 4 to delta 13) and trans (delta 2 and delta 5 to delta 13] to stearic acid by a rumen Fusocillus sp. were examined [13].

Anatomical context of EINECS 247-991-8

• Correlating with the changes in the desaturation activity, concentration of octadecenoic acid was increased in hepatic microsomes, whole liver and serum [14].
• Beta-oxidation of the geometric and positional isomers of octadecenoic acid by rat heart and liver mitochondria [15].
• Accumulation and depletion of trans octadecenoic acid in rat peripheral nerve phospholipid [16].
• Octadecenoic acid content was significantly higher in blood plasma of animals fed added oils from cottonseed and soybean than those fed with corn oil and control [17].
• The percentage of octadecenoic acid in total fatty acid of hepatic microsomes, homogenates and serum was increased markedly by the administration of peroxisome proliferators [18].

Associations of EINECS 247-991-8 with other chemical compounds

• Cell free preparations of Tetrahymena thermophila contain an enzyme that catalyzes the direct desaturation of stearoyl CoA to octadecenoic acid [19].
• 11-[3- -14 C] Octadecenoic acid, 11,14-[1- -14C] nonadecadienoic acid, 11,14-[1- -14 C] eicosadienoic acid, 11,14-[1- -14 C] heneicosadienoic acid and 11,14,17-[3- -14 C] eicosatrienoic acid were fed and injected into tail veins of rats raised on balanced and fat-free diets [20].

References