The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Scd1  -  stearoyl-Coenzyme A desaturase 1

Rattus norvegicus

Synonyms: Acyl-CoA desaturase 1, Delta(9)-desaturase 1, Delta-9 desaturase 1, Fatty acid desaturase 1, Scd, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Scd1


High impact information on Scd1


Chemical compound and disease context of Scd1


Biological context of Scd1


Anatomical context of Scd1


Associations of Scd1 with chemical compounds


Other interactions of Scd1


Analytical, diagnostic and therapeutic context of Scd1


  1. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. Tovar, A.R., Torre-Villalvazo, I., Ochoa, M., Elías, A.L., Ortíz, V., Aguilar-Salinas, C.A., Torres, N. J. Lipid Res. (2005) [Pubmed]
  2. Stearoyl-coenzyme A desaturase activity in Novikoff hepatoma. Prasad, M.R., Joshi, V.C. Lipids (1979) [Pubmed]
  3. Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet. Brenner, R.R., Rimoldi, O.J., Lombardo, Y.B., González, M.S., Bernasconi, A.M., Chicco, A., Basabe, J.C. Lipids (2003) [Pubmed]
  4. Analysis of the stearoyl-CoA desaturase system in the Morris hepatoma 7288C and 7288CTC. Zoeller, R.A., Wood, R. Lipids (1984) [Pubmed]
  5. Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids. Jones, B.H., Maher, M.A., Banz, W.J., Zemel, M.B., Whelan, J., Smith, P.J., Moustaïd, N. Am. J. Physiol. (1996) [Pubmed]
  6. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. Gutiérrez-Juárez, R., Pocai, A., Mulas, C., Ono, H., Bhanot, S., Monia, B.P., Rossetti, L. J. Clin. Invest. (2006) [Pubmed]
  7. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Tomita, K., Azuma, T., Kitamura, N., Nishida, J., Tamiya, G., Oka, A., Inokuchi, S., Nishimura, T., Suematsu, M., Ishii, H. Gastroenterology (2004) [Pubmed]
  8. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. Heinemann, F.S., Korza, G., Ozols, J. J. Biol. Chem. (2003) [Pubmed]
  9. Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease. Heinemann, F.S., Ozols, J. Mol. Biol. Cell (1998) [Pubmed]
  10. A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. Bellenger, J., Bellenger, S., Clément, L., Mandard, S., Diot, C., Poisson, J.P., Narce, M. FASEB J. (2004) [Pubmed]
  11. Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance. Voss, M.D., Beha, A., Tennagels, N., Tschank, G., Herling, A.W., Quint, M., Gerl, M., Metz-Weidmann, C., Haun, G., Korn, M. Diabetologia (2005) [Pubmed]
  12. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang, F., Pan, T., Nielsen, L.D., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  13. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Falvella, F.S., Pascale, R.M., Gariboldi, M., Manenti, G., De Miglio, M.R., Simile, M.M., Dragani, T.A., Feo, F. Carcinogenesis (2002) [Pubmed]
  14. Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. Mihara, K. J. Biochem. (1990) [Pubmed]
  15. Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Saether, T., Tran, T.N., Rootwelt, H., Christophersen, B.O., Haugen, T.B. Biol. Reprod. (2003) [Pubmed]
  16. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. Choi, Y., Kim, Y.C., Han, Y.B., Park, Y., Pariza, M.W., Ntambi, J.M. J. Nutr. (2000) [Pubmed]
  17. Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of GAP-43 subsequent to the activation of SREBP-1 and the up-regulation of stearoyl-CoA desaturase during postnatal development of the brain. Velasco, A., Tabernero, A., Medina, J.M. Brain Res. (2003) [Pubmed]
  18. Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. Kakuma, T., Lee, Y., Unger, R.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  19. CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression. Lin, J., Choi, Y.H., Hartzell, D.L., Li, C., Della-Fera, M.A., Baile, C.A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  20. Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet. Polson, D.A., Thompson, M.P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  21. Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. Michel, C., van Echten-Deckert, G., Rother, J., Sandhoff, K., Wang, E., Merrill, A.H. J. Biol. Chem. (1997) [Pubmed]
  22. Induction of stearoyl CoA desaturase is associated with high-level induction of emerin RNA. Mziaut, H., Korza, G., Elkahloun, A.G., Ozols, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  23. Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions. Breuer, S., Pech, K., Buss, A., Spitzer, C., Ozols, J., Hol, E.M., Heussen, N., Noth, J., Schwaiger, F.W., Schmitt, A.B. BMC neuroscience [electronic resource]. (2004) [Pubmed]
WikiGenes - Universities