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Scd1  -  stearoyl-Coenzyme A desaturase 1

Rattus norvegicus

Synonyms: Acyl-CoA desaturase 1, Delta(9)-desaturase 1, Delta-9 desaturase 1, Fatty acid desaturase 1, Scd, ...
 
 
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Disease relevance of Scd1

 

High impact information on Scd1

 

Chemical compound and disease context of Scd1

 

Biological context of Scd1

 

Anatomical context of Scd1

 

Associations of Scd1 with chemical compounds

 

Other interactions of Scd1

 

Analytical, diagnostic and therapeutic context of Scd1

References

  1. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. Tovar, A.R., Torre-Villalvazo, I., Ochoa, M., Elías, A.L., Ortíz, V., Aguilar-Salinas, C.A., Torres, N. J. Lipid Res. (2005) [Pubmed]
  2. Stearoyl-coenzyme A desaturase activity in Novikoff hepatoma. Prasad, M.R., Joshi, V.C. Lipids (1979) [Pubmed]
  3. Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet. Brenner, R.R., Rimoldi, O.J., Lombardo, Y.B., González, M.S., Bernasconi, A.M., Chicco, A., Basabe, J.C. Lipids (2003) [Pubmed]
  4. Analysis of the stearoyl-CoA desaturase system in the Morris hepatoma 7288C and 7288CTC. Zoeller, R.A., Wood, R. Lipids (1984) [Pubmed]
  5. Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids. Jones, B.H., Maher, M.A., Banz, W.J., Zemel, M.B., Whelan, J., Smith, P.J., Moustaïd, N. Am. J. Physiol. (1996) [Pubmed]
  6. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. Gutiérrez-Juárez, R., Pocai, A., Mulas, C., Ono, H., Bhanot, S., Monia, B.P., Rossetti, L. J. Clin. Invest. (2006) [Pubmed]
  7. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Tomita, K., Azuma, T., Kitamura, N., Nishida, J., Tamiya, G., Oka, A., Inokuchi, S., Nishimura, T., Suematsu, M., Ishii, H. Gastroenterology (2004) [Pubmed]
  8. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. Heinemann, F.S., Korza, G., Ozols, J. J. Biol. Chem. (2003) [Pubmed]
  9. Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease. Heinemann, F.S., Ozols, J. Mol. Biol. Cell (1998) [Pubmed]
  10. A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. Bellenger, J., Bellenger, S., Clément, L., Mandard, S., Diot, C., Poisson, J.P., Narce, M. FASEB J. (2004) [Pubmed]
  11. Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance. Voss, M.D., Beha, A., Tennagels, N., Tschank, G., Herling, A.W., Quint, M., Gerl, M., Metz-Weidmann, C., Haun, G., Korn, M. Diabetologia (2005) [Pubmed]
  12. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang, F., Pan, T., Nielsen, L.D., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  13. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Falvella, F.S., Pascale, R.M., Gariboldi, M., Manenti, G., De Miglio, M.R., Simile, M.M., Dragani, T.A., Feo, F. Carcinogenesis (2002) [Pubmed]
  14. Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. Mihara, K. J. Biochem. (1990) [Pubmed]
  15. Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Saether, T., Tran, T.N., Rootwelt, H., Christophersen, B.O., Haugen, T.B. Biol. Reprod. (2003) [Pubmed]
  16. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. Choi, Y., Kim, Y.C., Han, Y.B., Park, Y., Pariza, M.W., Ntambi, J.M. J. Nutr. (2000) [Pubmed]
  17. Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of GAP-43 subsequent to the activation of SREBP-1 and the up-regulation of stearoyl-CoA desaturase during postnatal development of the brain. Velasco, A., Tabernero, A., Medina, J.M. Brain Res. (2003) [Pubmed]
  18. Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. Kakuma, T., Lee, Y., Unger, R.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  19. CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression. Lin, J., Choi, Y.H., Hartzell, D.L., Li, C., Della-Fera, M.A., Baile, C.A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  20. Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet. Polson, D.A., Thompson, M.P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  21. Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. Michel, C., van Echten-Deckert, G., Rother, J., Sandhoff, K., Wang, E., Merrill, A.H. J. Biol. Chem. (1997) [Pubmed]
  22. Induction of stearoyl CoA desaturase is associated with high-level induction of emerin RNA. Mziaut, H., Korza, G., Elkahloun, A.G., Ozols, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  23. Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions. Breuer, S., Pech, K., Buss, A., Spitzer, C., Ozols, J., Hol, E.M., Heussen, N., Noth, J., Schwaiger, F.W., Schmitt, A.B. BMC neuroscience [electronic resource]. (2004) [Pubmed]
 
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