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Chemical Compound Review

SureCN26605     4-(3-bromophenyl)-N-(pyridin- 4-ylmethyl)-5...

Synonyms: DB04669, AC1NS1PM, CT8, triazolo[1,5-a]pyrimidine 3
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Disease relevance of TRIAZOLOPYRIMIDINE


High impact information on TRIAZOLOPYRIMIDINE


Biological context of TRIAZOLOPYRIMIDINE


Anatomical context of TRIAZOLOPYRIMIDINE


Associations of TRIAZOLOPYRIMIDINE with other chemical compounds



  • Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists [3].
  • In accordance with the EPPO guideline for the efficacy evaluation of plant protection products, resistance risk analysis PP 1/213(1), a method was established to determine the baseline sensitivity of key weed species to florasulam, a new triazolopyrimidine sulfonanilide herbicide for post-emergence control of dicotyledonous weeds in cereals [12].

Analytical, diagnostic and therapeutic context of TRIAZOLOPYRIMIDINE


  1. Triazolopyrimidine (trapidil), a platelet-derived growth factor antagonist, inhibits parathyroid bone disease in an animal model for chronic hyperparathyroidism. Lotinun, S., Sibonga, J.D., Turner, R.T. Endocrinology (2003) [Pubmed]
  2. Inhibition of the CD40 pathway of monocyte activation by triazolopyrimidine. Zhou, L., Ismaili, J., Stordeur, P., Thielemans, K., Goldman, M., Pradier, O. Clin. Immunol. (1999) [Pubmed]
  3. Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists. Vu, C.B., Shields, P., Peng, B., Kumaravel, G., Jin, X., Phadke, D., Wang, J., Engber, T., Ayyub, E., Petter, R.C. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  4. Suppression of fibroblast proliferation in vitro and of myointimal hyperplasia in vivo by the triazolopyrimidine, Trapidil. Tiell, M.L., Sussman, I.I., Gordon, P.B., Saunders, R.N. Artery (1983) [Pubmed]
  5. Trapidil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit. Liu, M.W., Roubin, G.S., Robinson, K.A., Black, A.J., Hearn, J.A., Siegel, R.J., King, S.B. Circulation (1990) [Pubmed]
  6. Antimitogenic effects of trapidil in coronary artery smooth muscle cells by direct activation of protein kinase A. Bönisch, D., Weber, A.A., Wittpoth, M., Osinski, M., Schrör, K. Mol. Pharmacol. (1998) [Pubmed]
  7. Fast and reproducible vascular neointima formation in the hamster carotid artery: effects of trapidil and captopril. Matsuno, H., Stassen, J.M., Hoylaerts, M.F., Vermylen, J., Deckmyn, H. Thromb. Haemost. (1995) [Pubmed]
  8. Effects of triazolopyrimidine on lipid peroxidation and nitric oxide levels in the corticosteroid-impaired healing of rat tracheal anastomoses. Polat, G., Talas, D.U., Polat, A., Nayci, A., Atiş, S., Bağdatoğlu, O., Cömelekoğlu, U., Atik, U. Cell Biochem. Funct. (2005) [Pubmed]
  9. A randomized comparison of trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, versus aspirin in prevention of angiographic restenosis after coronary artery Palmaz-Schatz stent implantation. Galassi, A.R., Tamburino, C., Nicosia, A., Russo, G., Grassi, R., Monaco, A., Giuffrida, G. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (1999) [Pubmed]
  10. Intragenic recombination in the CSR1 locus of Arabidopsis. Mourad, G., Haughn, G., King, J. Mol. Gen. Genet. (1994) [Pubmed]
  11. Chemical marker for ALS-inhibitor herbicides: 2-aminobutyric acid proportional in sub-lethal applications. Loper, B.R., Cobb, W.T., Anderson, K.A. J. Agric. Food Chem. (2002) [Pubmed]
  12. Establishment of the baseline sensitivity and monitoring response of Papaver rhoeas populations to florasulam. Paterson, E.A., Shenton, Z.L., Straszewski, A.E. Pest Manag. Sci. (2002) [Pubmed]
  13. Effects of trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, in preventing restenosis after percutaneous transluminal coronary angioplasty. Okamoto, S., Inden, M., Setsuda, M., Konishi, T., Nakano, T. Am. Heart J. (1992) [Pubmed]
  14. Analysis of triazolopyrimidine herbicides in soils using field-enhanced sample injection-coelectroosmotic capillary electrophoresis combined with solid-phase extraction. Hernández-Borges, J., García-Montelongo, F.J., Cifuentes, A., Rodríguez-Delgado, M.A. Journal of chromatography. A. (2005) [Pubmed]
  15. The trapidil restenosis trial (STARC study): background, methods and clinical characteristics of the patient population. Maresta, A., Balducelli, M., Cantini, L., Casari, A., Chioin, R., Fontanelli, A., Monici Preti, P.A., Repetto, S., Raffaghello, S. Clinical trials and meta-analysis. (1994) [Pubmed]
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