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Gene Review

CSR1  -  acetolactate synthase

Arabidopsis thaliana

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Disease relevance of CSR1

  • Four mutants (A122V, W574S, W574L and S653N) of the AHAS gene from Arabidopsis thaliana were constructed, expressed in Escherichia coli, and the enzymes were purified [1].

High impact information on CSR1

  • The Trp pathway enzymes and cytosolic glutamine synthetase were induced under all of the amino acid starvation test conditions, whereas methionine synthase and acetolactate synthase were not [2].
  • This report describes the 3D structure of Arabidopsis thaliana AHAS in complex with five sulfonylureas (to 2.5 A resolution) and with the imidazolinone, imazaquin (IQ; 2.8 A) [3].
  • The ALS gene encoding acetolactase synthase, which confers resistance to chlorsulfuron, functioned as a versatile marker for selection of plants grown in tissue culture as well as in soil [4].
  • Nucleotide sequence of a mutant acetolactate synthase gene from an imidazolinone-resistant Arabidopsis thaliana var. Columbia [5].
  • Taking advantage of the properties of such migration-selection balance, an artificial cline was built up to optimize the conditions where the fitness cost of two herbicide-resistant mutants (acetolactate synthase and auxin-induced target genes) in the model species Arabidopsis thaliana could be more accurately measured [6].

Biological context of CSR1


Associations of CSR1 with chemical compounds


Other interactions of CSR1


Analytical, diagnostic and therapeutic context of CSR1


  1. Herbicide-resistant forms of Arabidopsis thaliana acetohydroxyacid synthase: characterization of the catalytic properties and sensitivity to inhibitors of four defined mutants. Chang, A.K., Duggleby, R.G. Biochem. J. (1998) [Pubmed]
  2. Induction of Arabidopsis tryptophan pathway enzymes and camalexin by amino acid starvation, oxidative stress, and an abiotic elicitor. Zhao, J., Williams, C.C., Last, R.L. Plant Cell (1998) [Pubmed]
  3. Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase. McCourt, J.A., Pang, S.S., King-Scott, J., Guddat, L.W., Duggleby, R.G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. High-frequency germinal transposition of DsALS in Arabidopsis. Honma, M.A., Baker, B.J., Waddell, C.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  5. Nucleotide sequence of a mutant acetolactate synthase gene from an imidazolinone-resistant Arabidopsis thaliana var. Columbia. Sathasivan, K., Haughn, G.W., Murai, N. Nucleic Acids Res. (1990) [Pubmed]
  6. Building of an experimental cline with Arabidopsis thaliana to estimate herbicide fitness cost. Roux, F., Giancola, S., Durand, S., Reboud, X. Genetics (2006) [Pubmed]
  7. Organization, inheritance and expression of acetohydroxyacid synthase genes in the cotton allotetraploid Gossypium hirsutum. Grula, J.W., Hudspeth, R.L., Hobbs, S.L., Anderson, D.M. Plant Mol. Biol. (1995) [Pubmed]
  8. A double mutant allele, csr1-4, of Arabidopsis thaliana encodes an acetolactate synthase with altered kinetics. Mourad, G., Williams, D., King, J. Planta (1995) [Pubmed]
  9. Costs of resistance: a test using transgenic Arabidopsis thaliana. Bergelson, J., Purrington, C.B., Palm, C.J., López-Gutiérrez, J.C. Proc. Biol. Sci. (1996) [Pubmed]
  10. Molecular characterization and genetic origin of the Brassica napus acetohydroxyacid synthase multigene family. Rutledge, R.G., Quellet, T., Hattori, J., Miki, B.L. Mol. Gen. Genet. (1991) [Pubmed]
  11. Intragenic recombination in the CSR1 locus of Arabidopsis. Mourad, G., Haughn, G., King, J. Mol. Gen. Genet. (1994) [Pubmed]
  12. Steady-state kinetics and molecular evolution of Escherichia coli MenD [(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase], an anomalous thiamin diphosphate-dependent decarboxylase-carboligase. Bhasin, M., Billinsky, J.L., Palmer, D.R. Biochemistry (2003) [Pubmed]
  13. Regulatory interactions in Arabidopsis thaliana acetohydroxyacid synthase. Lee, Y.T., Duggleby, R.G. FEBS Lett. (2002) [Pubmed]
  14. The dominance of the herbicide resistance cost in several Arabidopsis thaliana mutant lines. Roux, F., Gasquez, J., Reboud, X. Genetics (2004) [Pubmed]
  15. Acetohydroxyacid synthase mutations conferring resistance to imidazolinone or sulfonylurea herbicides in sunflower. Kolkman, J.M., Slabaugh, M.B., Bruniard, J.M., Berry, S., Bushman, B.S., Olungu, C., Maes, N., Abratti, G., Zambelli, A., Miller, J.F., Leon, A., Knapp, S.J. Theor. Appl. Genet. (2004) [Pubmed]
  16. Molecular characterization of true and ectopic gene targeting events at the acetolactate synthase gene in Arabidopsis. Endo, M., Osakabe, K., Ichikawa, H., Toki, S. Plant Cell Physiol. (2006) [Pubmed]
  17. Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl. Pang, S.S., Guddat, L.W., Duggleby, R.G. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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