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Chemical Compound Review

Trimidox     4-[amino- (hydroxyamino)methylidene]- 2,6...

Synonyms: CCRIS 7910, AG-H-94543, CHEMBL1214553, AC1NUZ8S, LS-29453, ...
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Disease relevance of Trimidox


High impact information on Trimidox


Chemical compound and disease context of Trimidox


Biological context of Trimidox


Anatomical context of Trimidox


Associations of Trimidox with other chemical compounds


Gene context of Trimidox

  • In contrast, extracellular signal-regulated kinase (ERK) inhibitors U0126 and PD98059 strongly potentiated the apoptotic effect of trimidox [16].
  • As trimidox was able to upregulate the expression of the transferrin receptor in HL-60 human promyelocytic leukaemia cells, we have now investigated the capability of trimidox to interfere with iron metabolism [17].
  • Trimidox induces c-myc expression, which is indispensible for apoptosis of N.1 cells, and expression of plasminogen activator/urokinase type (upa), which supports the apoptotic process under more physiological conditions [5].
  • This report shows that the induction of apoptosis by trimidox occurs through a cytochrome c-dependent pathway, which sequentially activates caspase-3 and caspase-9 [16].

Analytical, diagnostic and therapeutic context of Trimidox

  • Viewed in concert, these findings suggest that trimidox is a new and potent inhibitor of ribonucleotide reductase and that it is a promising candidate for the chemotherapy of cancer in humans [2].
  • Amidox (AX), didox (DX) and trimidox (TX), compounds synthetized as new ribonucleotide reductase inhibitors, have been investigated by ultraviolet (UV) spectrophotometry, polarography and high performance liquid chromatography (HPLC) [18].
  • A significant increase in the amount of cytochrome c release was detected after treatment with trimidox [16].


  1. In vivo and in vitro comparison of the short-term hematopoietic toxicity between hydroxyurea and trimidox or didox, novel ribonucleotide reductase inhibitors with potential anti-HIV-1 activity. Mayhew, C.N., Phillips, J.D., Greenberg, R.N., Birch, N.J., Elford, H.L., Gallicchio, V.S. Stem Cells (1999) [Pubmed]
  2. Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase. Szekeres, T., Gharehbaghi, K., Fritzer, M., Woody, M., Srivastava, A., van't Riet, B., Jayaram, H.N., Elford, H.L. Cancer Chemother. Pharmacol. (1994) [Pubmed]
  3. Trimidox-mediated morphological changes during erythroid differentiation is associated with the stimulation of hemoglobin and F-cell production in human K562 cells. Iyamu, E.W., Adunyah, S.E., Elford, H.L., Fasold, H., Turner, E.A. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  4. Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells. Figul, M., Söling, A., Dong, H.J., Chou, T.C., Rainov, N.G. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  5. The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells. Rosenberger, G., Fuhrmann, G., Grusch, M., Fassl, S., Elford, H.L., Smid, K., Peters, G.J., Szekeres, T., Krupitza, G. Life Sci. (2000) [Pubmed]
  6. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Szekeres, T., Fritzer, M., Strobl, H., Gharehbaghi, K., Findenig, G., Elford, H.L., Lhotka, C., Schoen, H.J., Jayaram, H.N. Blood (1994) [Pubmed]
  7. Trimidox, an inhibitor of ribonucleotide reductase, induces apoptosis and activates caspases in HL-60 promyelocytic leukemia cells. Fritzer-Szekeres, M., Grusch, M., Luxbacher, C., Horvath, S., Krupitza, G., Elford, H.L., Szekeres, T. Exp. Hematol. (2000) [Pubmed]
  8. Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds. Lee, R., Beauparlant, P., Elford, H., Ponka, P., Hiscott, J. Virology (1997) [Pubmed]
  9. Enhanced effects of adriamycin by combination with a new ribonucleotide reductase inhibitor, trimidox, in murine leukemia. Fritzer-Szekeres, M., Novotny, L., Romanova, D., Göbl, R., Sedlak, J., Vachalkova, A., Rauko, P., Elford, H.L., Szekeres, T. Life Sci. (1998) [Pubmed]
  10. Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea. Mayhew, C.N., Mampuru, L.J., Chendil, D., Ahmed, M.M., Phillips, J.D., Greenberg, R.N., Elford, H.L., Gallicchio, V.S. Antiviral Res. (2002) [Pubmed]
  11. Hydroxyurea and trimidox enhance the radiation effect in human pancreatic adenocarcinoma cells. Leyden, D., Ahmed, N., Hassan, H.T. Anticancer Res. (2000) [Pubmed]
  12. Interaction of gallium nitrate with other inhibitors of ribonucleotide reductase: effects on the proliferation of human leukemic cells. Myette, M.S., Elford, H.L., Chitambar, C.R. Cancer Lett. (1998) [Pubmed]
  13. Short-term treatment with novel ribonucleotide reductase inhibitors Trimidox and Didox reverses late-stage murine retrovirus-induced lymphoproliferative disease with less bone marrow toxicity than hydroxyurea. Mayhew, C.N., Phillips, J.D., Cibull, M.L., Elford, H.L., Gallicchio, V.S. Antivir. Chem. Chemother. (2002) [Pubmed]
  14. Combination of inhibitors of lymphocyte activation (hydroxyurea, trimidox, and didox) and reverse transcriptase (didanosine) suppresses development of murine retrovirus-induced lymphoproliferative disease. Mayhew, C.N., Sumpter, R., Inayat, M., Cibull, M., Phillips, J.D., Elford, H.L., Gallicchio, V.S. Antiviral Res. (2005) [Pubmed]
  15. Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells. Fritzer-Szekeres, M., Salamon, A., Grusch, M., Horvath, Z., Höchtl, T., Steinbrugger, R., Jäger, W., Krupitza, G., Elford, H.L., Szekeres, T. Biochem. Pharmacol. (2002) [Pubmed]
  16. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Kanno, S., Uwai, K., Tomizawa, A., Hiura, T., Osanai, Y., Ujibe, M., Takeshita, M., Ohtake, T., Kimura, K., Ishikawa, M. Basic & clinical pharmacology & toxicology. (2006) [Pubmed]
  17. Iron binding capacity of trimidox (3,4,5-trihydroxybenzamidoxime), a new inhibitor of the enzyme ribonucleotide reductase. Szekeres, T., Vielnascher, E., Novotny, L., Vachalkova, A., Fritzer, M., Findenig, G., Göbl, R., Elford, H.L., Goldenberg, H. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. (1995) [Pubmed]
  18. The new inhibitors of ribonucleotide reductase--comparison of some physico-chemical properties. Romanova, D., Vachalkova, A., Szekeres, T., Elford, H.L., Novotny, L. Journal of pharmaceutical and biomedical analysis. (1997) [Pubmed]
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