Disease relevance of undecylenic acid

• Topical undecylenic acid for herpes simplex labialis: a multicenter, placebo-controlled trial [1].
• A multicenter, patient-initiated, double-blind, placebo-controlled trial of 15% undecylenic acid cream was conducted with 573 patients with recurrent herpes labialis [1].
• Comparison of in vitro activity of undecylenic acid and tolnaftate against athlete's foot fungi [2].
• Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution [3].
• Effect of undecylenic acid as a topical microbicide against genital herpes infection in mice and guinea pigs [4].

Psychiatry related information on undecylenic acid

• By controlling the reaction time, high-quality carboxy-terminated monolayers, comparable to those formed by ester hydrolysis, can be obtained from a direct, one-step photochemical reaction between H-Si and undecylenic acid [5].

High impact information on undecylenic acid

• When the prepolymer is doped with 0.5 wt % undecylenic acid (UDA), the electroosmotic mobility in a modified PDMS channel rises to (7.6 +/- 0.2) x 10(-)(4) cm(2) V(-)(1) s(-)(1) (in HEPES buffer at pH 8.5), which is nearly twice that in the native PDMS channel [6].
• Undecylenic acid inhibits morphogenesis of Candida albicans [7].
• Undecylenic acid significantly reduced the incidence and duration of viral shedding and the duration and severity of itching but did not increase abortive episodes or reduce times to healing, crusting, or progression of lesion size [1].
• Undecylenic acid 15% cream reduces viral shedding in recurrent herpes labialis, but clinical benefits are minimal and largely restricted to patients initiating therapy during the prodrome [1].
• After hydrogenation of the surface, 10-undecenoic acid, an omega-unsaturated fatty acid, is tethered by 254nm photochemical attachment [8].

Chemical compound and disease context of undecylenic acid

• Structure and polymer form of poly-3-hydroxyalkanoates produced by Pseudomonas oleovorans grown with mixture of sodium octanoate/undecylenic acid and sodium octanoate/5-phenylvaleric acid [9].

Biological context of undecylenic acid

• A simple model is presented that shows that the grafting kinetics is about twice as fast for undecylenic acid as for 1-decene [10].

Associations of undecylenic acid with other chemical compounds

• Testosterone esterified with undecylenic acid was only effective when administered in arachis oil [11].
• Comparative in vitro & in vivo evaluation of tolciclate, tolnaftate, miconazole, clotrimazole & undecylenic acid against Trichophyton mentagrophytes [12].
• We have found that the medium-chain fatty acids (MCFAs) undecanoic acid (11:0), 10-undecenoic acid (11:1 Delta 10), and lauric acid (12:0) can affect the growth of Saccharomyces cerevisiae in a dose-dependent manner [13].

Gene context of undecylenic acid

• Undecylenic acid (UA), a monosaturated fatty acid, is the active ingredient in a number of over-the-counter (OTC) antifungal spray powders, that also exhibits in vitro antibacterial and antiviral activity, including herpes simplex virus (HSV) activity [4].

Analytical, diagnostic and therapeutic context of undecylenic acid

• To demonstrate these effects, we show that the electrophoretic separation of immunocomplexes in free solution can be readily accomplished in a microfluidic chip made of UDA-doped (0.5 wt %) PDMS with a dynamic coating of DDM [6].
• A highly sensitive and selective method for the determination of sorbic (SA) and undecylenic acid (UA) in cosmetic formulations by a high performance liquid chromatography method with electrochemical detection (ECD) is described [14].
• In a double-blind study, the efficacy of 1% tolnaftate cream, 3% undecylenic acid and its zinc salt, and a placebo cream were tested in dermatophytosis of the glaborous skin and groin [15].

References