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MeSH Review

Herpes Labialis

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Disease relevance of Herpes Labialis


High impact information on Herpes Labialis

  • Does idoxuridine help herpes labialis [6]?
  • CONCLUSIONS: Penciclovir cream is the first treatment to clearly demonstrate an impact on the course of recurrent herpes labialis in immunocompetent patients [1].
  • To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays [7].
  • The findings in people with cold sores support our hypothesis that APOE-epsilon 4 and HSV1 together are damaging in the nervous system [8].
  • Peripheral blood mononuclear cells separated from the blood of 29 volunteers within 3 wk of the onset of recurrent oral herpes labialis spontaneously secreted IFN-gamma (and small amounts of IFN-beta) into the culture medium in varying amounts (mean = 77 U/ml, SE = 17) [9].

Chemical compound and disease context of Herpes Labialis


Biological context of Herpes Labialis


Anatomical context of Herpes Labialis

  • Results from a paired t test showed that there was a significant decrease in plasma levels of natural killer cells and serum levels of epinephrine from the week before recurrent herpes labialis lesion occurrence (T1,9 = 2.70; p < 0.05) to the week of recrudescence (T1,9 = 2.41; p < 0.05) [17].
  • To investigate whether genetic factors linked to the human leukocyte antigens (HLA) might influence individual resistance to recurrent herpes labialis (RHL), we studied the frequencies of HLA-A, -B, and -C antigens in a sample of Sicilian population [18].

Gene context of Herpes Labialis

  • These findings suggest that spontaneous IFN production may not occur predictably after an episode of herpes labialis [19].
  • Cell-mediated immune responses in patients with recurrent Herpes Simplex infections. II. Infection-associated deficiency of lymphokine production in patients with recurrent herpes labialis or herpes progenitalis [20].
  • Herpes labialis associated with recombinant human ciliary neurotrophic factor [21].
  • SLE risk increased with history of shingles (OR 2.5, 95% CI 1.1-5.9) and with frequent (more than once per year) cold sores in the 3 years before diagnosis (OR 2.8, 95% CI 1.4-5.4) [22].
  • MATERIALS/METHODS: Twenty patients (12 females; median age 26.6 years) with a history of recurrent herpes labialis >6 episodes each year were treated with systemic zinc sulphate 22.5 mg twice daily for the months of February, March, September and October [23].

Analytical, diagnostic and therapeutic context of Herpes Labialis


  1. Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical Penciclovir Collaborative Study Group. Spruance, S.L., Rea, T.L., Thoming, C., Tucker, R., Saltzman, R., Boon, R. JAMA (1997) [Pubmed]
  2. Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Wozniak, M.A., Itzhaki, R.F., Faragher, E.B., James, M.W., Ryder, S.D., Irving, W.L. Hepatology (2002) [Pubmed]
  3. Prophylactic chemotherapy with acyclovir for recurrent herpes simplex labialis. Spruance, S.L. J. Med. Virol. (1993) [Pubmed]
  4. Enhancement of the eighth cranial nerve and labyrinth on MR imaging in sudden sensorineural hearing loss associated with human herpesvirus 1 infection: case report. Lavi, E.S., Sklar, E.M. AJNR. American journal of neuroradiology. (2001) [Pubmed]
  5. Expression of MxA protein in inflammatory dermatoses. Fäh, J., Pavlovic, J., Burg, G. J. Histochem. Cytochem. (1995) [Pubmed]
  6. Does idoxuridine help herpes labialis? Felser, J.M., Croen, K.D., Sawyer, M.H., Rooney, J.F., Ostrove, J.M., Straus, S.E. N. Engl. J. Med. (1985) [Pubmed]
  7. Acyclovir prevents reactivation of herpes simplex labialis in skiers. Spruance, S.L., Hamill, M.L., Hoge, W.S., Davis, L.G., Mills, J. JAMA (1988) [Pubmed]
  8. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease. Itzhaki, R.F., Lin, W.R., Shang, D., Wilcock, G.K., Faragher, B., Jamieson, G.A. Lancet (1997) [Pubmed]
  9. gamma Interferon production appears to predict time of recurrence of herpes labialis. Cunningham, A.L., Merigan, T.C. J. Immunol. (1983) [Pubmed]
  10. Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferons. Valle, M.J., Jordan, G.W., Haahr, S., Merigan, T.C. J. Immunol. (1975) [Pubmed]
  11. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Spruance, S.L., Jones, T.M., Blatter, M.M., Vargas-Cortes, M., Barber, J., Hill, J., Goldstein, D., Schultz, M. Antimicrob. Agents Chemother. (2003) [Pubmed]
  12. A double-blind, controlled trial of levamisole in the treatment of recurrent herpes labialis. Russell, A.S., Brisson, E., Grace, M. J. Infect. Dis. (1978) [Pubmed]
  13. Effect of foscarnet cream on experimental UV radiation-induced herpes labialis. Bernstein, D.I., Schleupner, C.J., Evans, T.G., Blumberg, D.A., Bryson, Y., Grafford, K., Broberg, P., Martin-Munley, S., Spruance, S.L. Antimicrob. Agents Chemother. (1997) [Pubmed]
  14. Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Evans, T.G., Bernstein, D.I., Raborn, G.W., Harmenberg, J., Kowalski, J., Spruance, S.L. Antimicrob. Agents Chemother. (2002) [Pubmed]
  15. Topical undecylenic acid for herpes simplex labialis: a multicenter, placebo-controlled trial. Shafran, S.D., Sacks, S.L., Aoki, F.Y., Tyrrell, D.L., Schlech, W.F., Mendelson, J., Rosenthal, D., Gill, M.J., Bader, R.L., Chang, I. J. Infect. Dis. (1997) [Pubmed]
  16. Valacyclovir for herpes simplex virus infection: long-term safety and sustained efficacy after 20 years' experience with acyclovir. Tyring, S.K., Baker, D., Snowden, W. J. Infect. Dis. (2002) [Pubmed]
  17. Immune, stress, and mood markers related to recurrent oral herpes outbreaks. Logan, H.L., Lutgendorf, S., Hartwig, A., Lilly, J., Berberich, S.L. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1998) [Pubmed]
  18. Lack of correlation between HLA-B35 resistance against herpes labialis and antibody titers to HSV-1. Gallina, G., Cumbo, V., Messina, P., Caprera, V., Lio, D., Caruso, C. Oral Surg. Oral Med. Oral Pathol. (1989) [Pubmed]
  19. Spontaneous and induced interferon production by peripheral blood mononuclear leukocytes from humans with herpes labialis. Green, J.A., Weiss, P.N., Spruance, S.L. J. Immunol. (1983) [Pubmed]
  20. Cell-mediated immune responses in patients with recurrent Herpes Simplex infections. II. Infection-associated deficiency of lymphokine production in patients with recurrent herpes labialis or herpes progenitalis. O'Reilly, R.J., Chibbaro, A., Anger, E., Lopez, C. J. Immunol. (1977) [Pubmed]
  21. Herpes labialis associated with recombinant human ciliary neurotrophic factor. Kriesel, J.D., Araneo, B., Petajan, J.P., Spruance, S.L., Stromatt, S. J. Infect. Dis. (1994) [Pubmed]
  22. Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history. Cooper, G.S., Dooley, M.A., Treadwell, E.L., St Clair, E.W., Gilkeson, G.S. Journal of clinical epidemiology. (2002) [Pubmed]
  23. Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy. Femiano, F., Gombos, F., Scully, C. J. Oral Pathol. Med. (2005) [Pubmed]
  24. Treatment of herpes labialis with acyclovir. Review of three clinical trials. Raborn, G.W., McGaw, W.T., Grace, M., Percy, J. Am. J. Med. (1988) [Pubmed]
  25. Valaciclovir as a single dose during prodrome of herpes facialis: a pilot randomized double-blind clinical trial. Chosidow, O., Drouault, Y., Garraffo, R., Veyssier, P. Br. J. Dermatol. (2003) [Pubmed]
  26. Anaesthetic management of caesarean section in a patient with active recurrent genital herpes and AIDS-related dementia. Birnbach, D.J., Bourlier, R.A., Choi, R., Thys, D.M. British journal of anaesthesia. (1995) [Pubmed]
  27. A case of herpes-associated erythema multiforme in a Japanese child. Uemura, T., Nagayama, M., Kawashima, M. J. Dermatol. (1993) [Pubmed]
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