The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Moxisylyte     [4-(2-dimethylaminoethoxy)-2- methyl-5...

Synonyms: Arlytene, Moxilite, Moxisylyt, Moxisilita, Opilon, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Thymoxamine


Psychiatry related information on Thymoxamine

  • We assessed the efficiency and tolerance of the alpha-blocking agent moxisylyte in 2 double-blind studies versus placebo performed in 12 neurogenic patients with spinal cord lesions and in 61 patients presenting with either psychogenic impotence (30) or erectile dysfunction that was predominantly neither psychogenic, hormonal nor neurogenic (31) [5].
  • To explore the role of alpha-1-adrenoreceptor-mediated pathways on human upper gut motor function in vivo, we studied the effects of the alpha-1-agonist phenylephrine and the alpha-1-antagonist thymoxamine on oro-caecal transit and antroduodenal motor activity [6].
  • 1 An alpha-adrenergic receptor blocking agent, thymoxamine (150 mg i.v.) in the early night sleep of young adults increased REM sleep duration and also brief awakenings in the early night, while slow wave sleep, stage 3+4, was diminished [7].
  • Thymoxamine HCl (10 mg/kg IP), a specific alpha-adrenergic receptor blocker, depressed self-stimulation at all sites, but significantly more severely at DA sites [8].

High impact information on Thymoxamine


Chemical compound and disease context of Thymoxamine


Biological context of Thymoxamine


Anatomical context of Thymoxamine


Associations of Thymoxamine with other chemical compounds

  • The non-selective alpha adrenoceptor antagonists phentolamine (10(-5) M) and thymoxamine (10(-5) M) and the alpha 1 adrenoceptor antagonist prazosin (10(-5) M) partially blocked the response to noradrenaline, while the alpha 2 adrenoceptor antagonist idazoxan (10(-5) M) and timolol (10(-5) M) had no effect [23].
  • Post-micturition residual volumes and clinical symptoms of 49 patients with MSA were evaluated at trial entry and after 4 weeks (prazosin; n=21 and moxisylyte; n=28) [24].
  • Five normal subjects were given on three separate occasions intravenous infusions of thymoxamine (0.15 mg kg-1 loading dose followed by 0.15 mg kg-1 h-1), chlorpheniramine (1.5 mg loading dose followed by 1.5 mg h-1) and normal saline (placebo) [22].
  • 6. alpha-Adrenoceptor blockade with thymoxamine (0.3 mg kg-1 bolus + 0.3 mg kg-1 h-1 infusion), singly and combined with intravenous propranolol (10 mg i.v. over 10 min), did not alter the pressor or tachycardic effects of 500 micrograms TRH [25].
  • Six normal males were given continuous 3 h i.v. infusions of normal saline, methoxamine (alpha-1 adrenoceptor agonist) and thymoxamine (alpha-1 adrenoceptor antagonist) [26].

Gene context of Thymoxamine

  • In in vitro studies with human and rabbit corpus cavernosum strips in organ chambers, the alpha-adrenergic receptor antagonists (alpha-ARAs) moxisylyte and yohimbine and their corresponding nitrosylated compounds, SNO-moxisylyte (NMI-221) and SNO-yohimbine (NMI-187), concentration-dependently relaxed endothelin-induced contraction [27].
  • Normal values were those of the International Continence Society. Alpha blocker test was done by intravenous injection of thymoxamine (0.5 mg/kg) and was considered as positive if urethral closure pressure (UCP) decrease was greater than 30% after 10 minutes [28].
  • Thymoxamine, a prodrug, is rapidly deacetylated in the plasma to give two phase I metabolites, DMAT and DAT, which are further sulpho- and glucuro-conjugated and then excreted mainly in the urine [29].

Analytical, diagnostic and therapeutic context of Thymoxamine


  1. Time course of thymoxamine reversal of phenylephrine-induced mydriasis. Wright, M.M., Skuta, G.L., Drake, M.V., Chang, L.F., Rabbani, R., Musch, D.C., Teikari, J. Arch. Ophthalmol. (1990) [Pubmed]
  2. Thymoxamine test. Differentiating angle-closure glaucoma form open-angle glaucoma with narrow angles. Wand, M., Grant, W.M. Arch. Ophthalmol. (1978) [Pubmed]
  3. Reduction of systemic vascular resistance by competitive alpha adrenergic blockage with thymoxamine after cardiopulmonary bypass for cardiac operations. Cottrell, A.J., Pearson, D.T. J. Thorac. Cardiovasc. Surg. (1981) [Pubmed]
  4. Intraocular thymoxamine for miosis during surgery. Grehn, F. Am. J. Ophthalmol. (1987) [Pubmed]
  5. Efficiency and side effects of intracavernous injections of moxisylyte in impotent patients: a dose-finding study versus placebo. Costa, P., Sarrazin, B., Bressolle, F., Colson, M.H., Bondil, P., Saudubray, F. J. Urol. (1993) [Pubmed]
  6. The effect of alpha-1-adrenoreceptor agonist and antagonist administration on human upper gastrointestinal transit and motility. McIntyre, A.S., Thompson, D.G., Burnham, W.R., Walker, E. Aliment. Pharmacol. Ther. (1992) [Pubmed]
  7. Apha-adrenergic receptor blockade increases human REM sleep. Oswald, I., Thacore, V.R., Adam, K., Brezinová, V. British journal of clinical pharmacology. (1975) [Pubmed]
  8. Catecholamines and self-stimulation: evidence suggesting a reinforcing role for noradrenaline and a motivating role for dopamine. Herberg, L.J., Stephens, D.N., Franklin, K.B. Pharmacol. Biochem. Behav. (1976) [Pubmed]
  9. Autonomic regulation of postprandial plasma somatostatin, gastrin, and insulin. Lucey, M.R., Wass, J.A., Fairclough, P., Webb, J., Webb, S., Medbak, S., Rees, L.H. Gut (1985) [Pubmed]
  10. Dose-related effect of moxisylyte on maximal urethral closing pressure in patients with spinal cord injuries. Costa, P., Bressolle, F., Sarrazin, B., Mosser, J., Sabatier, R. Clin. Pharmacol. Ther. (1993) [Pubmed]
  11. Effects of alpha 1-adrenergic blockade on pulsatile luteinizing hormone, follicle-stimulating hormone, and prolactin secretion in polycystic ovary syndrome. Paradisi, R., Venturoli, S., Capelli, M., Spada, M., Giambiasi, M.E., Magrini, O., Porcu, E., Fabbri, R., Flamigni, C. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  12. The effect of thymoxamine and cromolyn sodium on postexercise bronchoconstriction in asthma. Patel, K.R., Kerr, J.W., MacDonald, E.B., MacKenzie, A.M. J. Allergy Clin. Immunol. (1976) [Pubmed]
  13. Effect of thymoxamine on aqueous humor formation in the normal human eye as measured by fluorophotometry. Lee, D.A., Brubaker, R.F., Nagataki, S. Invest. Ophthalmol. Vis. Sci. (1981) [Pubmed]
  14. Double-blind multicenter study comparing alprostadil alpha-cyclodextrin with moxisylyte chlorhydrate in patients with chronic erectile dysfunction. Buvat, J., Costa, P., Morlier, D., Lecocq, B., Stegmann, B., Albrecht, D. J. Urol. (1998) [Pubmed]
  15. Evaluation of the effect of thymoxamine solution 0.5% on mydriasis induced by ibopamine solution 1%. Drago, F., Dal Bello, A., Marino, V., Pisati, R., Lodola, E., Barbieri, P. Eur. J. Clin. Pharmacol. (1993) [Pubmed]
  16. Reversal of tropicamide-induced mydriasis by thymoxamine eye drops. McKinna, H., Stewart-Jones, J.H., Edgar, D.F., Turner, P. Current medical research and opinion. (1988) [Pubmed]
  17. Intraocular thymoxamine or acetylcholine for the reversal of mydriasis. Pfeiffer, N., Grehn, F., Wellek, S., Schwenn, O. German journal of ophthalmology. (1994) [Pubmed]
  18. Pharmacokinetics of moxisylyte in healthy volunteers after intravenous and intracavernous administration. Costa, P., Bressolle, F., Sarrazin, B., Mosser, J., Galtier, M. Journal of pharmaceutical sciences. (1993) [Pubmed]
  19. The esterase-like activity of serum albumin may be due to cholinesterase contamination. Chapuis, N., Brühlmann, C., Reist, M., Carrupt, P.A., Mayer, J.M., Testa, B. Pharm. Res. (2001) [Pubmed]
  20. Inhibition of the activity of sympathetic preganglionic neurones and neurones activated by visceral afferents, by alpha-methylnoradrenaline and endogenous catecholamines. Kadzielawa, K. Neuropharmacology (1983) [Pubmed]
  21. Pilot experiments on the actions of drugs injected into the human corpus cavernosum penis. Brindley, G.S. Br. J. Pharmacol. (1986) [Pubmed]
  22. Thymoxamine: lack of antihistaminic effects in clinical doses in man. Al-Damluji, S., Grossman, A., Turner, P., Besser, G.M. British journal of clinical pharmacology. (1987) [Pubmed]
  23. Pharmacological characterization of human ciliary muscle adrenoceptors in vitro. Zetterström, C., Hahnenberger, R. Exp. Eye Res. (1988) [Pubmed]
  24. Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte. Sakakibara, R., Hattori, T., Uchiyama, T., Suenaga, T., Takahashi, H., Yamanishi, T., Egoshi, K., Sekita, N. J. Auton. Nerv. Syst. (2000) [Pubmed]
  25. The acute cardiovascular actions of intravenous thyrotrophin releasing hormone (TRH) in man are mediated by non-catecholaminergic mechanisms. Bouloux, P.M., Corsello, S., Besser, M., Grossman, A. British journal of clinical pharmacology. (1996) [Pubmed]
  26. Food-induced cortisol secretion is mediated by central alpha-1 adrenoceptor modulation of pituitary ACTH secretion. Al-Damluji, S., Iveson, T., Thomas, J.M., Pendlebury, D.J., Rees, L.H., Besser, G.M. Clin. Endocrinol. (Oxf) (1987) [Pubmed]
  27. Design and evaluation of nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of impotence. de Tejada, I.S., Garvey, D.S., Schroeder, J.D., Shelekhin, T., Letts, L.G., Fernández, A., Cuevas, B., Gabancho, S., Martínez, V., Angulo, J., Trocha, M., Marek, P., Cuevas, P., Tam, S.W. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  28. Urodynamics in patients with pheochromocytoma: a peri-operative study of 10 cases. Carnaille, B.M., Rigot, J.M., Bailleul, J.P., Quievreux, J.L., Wemeau, J.L., Proye, C.A. World journal of surgery. (1992) [Pubmed]
  29. Pharmacokinetics of a prodrug thymoxamine: dose-dependence of the metabolite ratio in healthy subjects. Marquer, C., Trouvin, J.H., Lacolle, J.Y., Dupont, C., Jacquot, C. European journal of drug metabolism and pharmacokinetics. (1991) [Pubmed]
  30. Determination of metabolites of thymoxamine in plasma by high performance liquid chromatography. Geahchan, A.E., Chambon, P.L. Anal. Chem. (1980) [Pubmed]
  31. Chronic paroxysmal hemicrania. X. On the autonomic involvement. Sjaastad, O., Aasly, J., Fredriksen, T., Wysocka Bakowska, M.M. Cephalalgia : an international journal of headache. (1986) [Pubmed]
  32. Multiple-dose pharmacokinetics of moxisylyte after oral administration to healthy volunteers. Costa, P., Bressolle, F., Jarroux, E., Sarrazin, B., Mosser, J., Navratil, H., Galtier, M. Journal of pharmaceutical sciences. (1993) [Pubmed]
WikiGenes - Universities