Disease relevance of Arklone P

• Adenovirus (Type 2)-infected HeLa cells were sonicated and treated with 1,1,2-trichlorotrifluoroethane [1].
• The interaction of Freon 113 (1,1,2-trichloro-1,2,2-trifluoroethane) and hypoxia on the heart conduction system was studied using electrocardiogram monitoring of isolated perfused rat hearts [2].
• Two cases of atrial fibrillation and one case of sudden death occurred in workers exposed to trifluorotrichloroethane (CFC 113) as a solvent/degreasing agent [3].
• Virus partially purified with Genetron 113 was precipitated by antisera to fowlpox and pigeon pox viruses [4].
• Based mainly on a 5 to 10% decrease in body weight gain at the 10,000 and 20,000 ppm exposure levels, the no-observed-effect level for FC-113 in this study was 2000 ppm [5].

High impact information on Arklone P

• The poly(U) polymerase was freed of membranes by sodium dodecyl sulfate and 1,1,2-trichlorotrifluoroethane extraction, and RNA was removed by precipitation with 2 M LiCl [6].
• Both positive and negative ions formed from Freons 1,1,1-trichlorotrifluoroethane (CFC 113a), 1,1,2-trichlorotrifluoroethane (CFC 113), and 1,1,1,2-tetrachlorodifluoroethane (CFC 112a) were analyzed using an atmospheric pressure chemical ionization mass spectrometry (APCI-MS) instrument [7].
• Exposing mice to Freon TF by inhalation more closely matches the normal route of human exposure to fluorocarbons [8].
• The widely used fluorocarbon refrigerant and cleaning solvent 1,1,2-trichloro-1,2,2-trifluoroethane (Freon TF), though generally considered biologically inert, enhances the metabolic activation of chemical carcinogens [8].
• Exposures to 1,1,2-trichloro-1,2,2-trifluoroethane or fluorocarbon (FC) 113 were evaluated in a horizontal laminar airflow (HLAF) clean room and a vertical laminar airflow (VLAF) clean room [9].

Chemical compound and disease context of Arklone P

• Chronic inhalation toxicity/carcinogenicity study in rats exposed to fluorocarbon 113 (FC-113) [5].

Biological context of Arklone P

• Human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane (FC113) [10].
• First, to examine the hepatic effects of occupational exposure to 1,1,2-trichloro-1,2,2-trifluoroethane (FC 113) using conventional and newer tests (serum bile acids) of hepatobiliary function [11].

Associations of Arklone P with other chemical compounds

• The initial investigation involved exposure to FC 113 while a follow-up study was undertaken after changes in work practices were made including replacement of FC 113 with trichloroethylene (TRI) [11].

Analytical, diagnostic and therapeutic context of Arklone P

• The same sensitivity was obtained with SVDV-spiked faeces, if the samples were pre-treated with 1,1,2-trichlorotrifluoroethane/chloroform and subsequently concentrated using an ultrafiltration system and RNA extracted with the Purescript kit [12].
• The floc composition in the CFC-113 system, where the drug particles cream, was determined by high-performance liquid chromatography analysis [13].
• Model metered dose inhalers (MDI) of both individual samples and mixtures of the drugs were formulated as suspensions in solvent CFC-113 [14].
• Freon-TF freeze drying method for SEM sample [15].

References