Chemical Compound Review:
NMOR 4-nitrosomorpholine
Synonyms:
NSC-139, CCRIS 473, NSC139, CHEMBL165908, LS-254, ...
Dombrowski,
Jost,
Manekeller,
Evert,
Grasl-Kraupp,
Luebeck,
Wagner,
Löw-Baselli,
de Gunst,
Waldhör,
Moolgavkar,
Schulte-Hermann,
Mayer,
Metzger,
Leonetti,
Beier,
Benner,
Bannasch,
Futakuchi,
Hirose,
Ogiso,
Kato,
Sano,
Ogawa,
Shirai,
- N-Nitrosodiethanolamine in synthetic cutting fluids: a part-per-hundred impurity. Fan, T.Y., Morrison, J., Rounbehler, D.P., Ross, R., Fine, D.H., Miles, W., Sen, N.P. Science (1977)
- Tumor induction by carcinogenic agents in aquarium fish. Pliss, G.B., Khudoley, V.V. J. Natl. Cancer Inst. (1975)
- Persistently increased expression of a 3-methylcholanthrene-inducible phenol uridine diphosphate-glucuronosyltransferase in rat hepatocyte nodules and hepatocellular carcinomas. Bock, K.W., Münzel, P.A., Röhrdanz, E., Schrenk, D., Eriksson, L.C. Cancer Res. (1990)
- Dose-response study with N-nitrosomorpholine in drinking water of F-344 rats. Lijinsky, W., Kovatch, R.M., Riggs, C.W., Walters, P.T. Cancer Res. (1988)
- Effect of ethanol on early stages in nitrosamine carcinogenesis in rat liver. Schwarz, M., Buchmann, A., Wiesbeck, G., Kunz, W. Cancer Lett. (1983)
- In vivo formation of N-nitrosomorpholine in CD-1 mice exposed by inhalation to nitrogen dioxide and by gavage to morpholine. Van Stee, E.W., Sloane, R.A., Simmons, J.E., Brunnemann, K.D. J. Natl. Cancer Inst. (1983)
- Greater effectiveness of hepatocyte and liver S9 preparations from hamsters than rat preparations in activating N-nitroso compounds to metabolites mutagenic to Salmonella. Raineri, R., Poiley, J.A., Andrews, A.W., Pienta, R.J., Lijinsky, W. J. Natl. Cancer Inst. (1981)
- Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Iyengar, R., Stuehr, D.J., Marletta, M.A. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Cocarcinogenic effects of islet hormones and N-nitrosomorpholine in hepatocarcinogenesis after intrahepatic transplantation of pancreatic islets in streptozotocin-diabetic rats. Dombrowski, F., Jost, C.M., Manekeller, S., Evert, M. Cancer Res. (2005)
- DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Schulte-Hermann, R., Timmermann-Trosiener, I., Barthel, G., Bursch, W. Cancer Res. (1990)
- Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants. Zeindl-Eberhart, E., Klugbauer, S., Dimitrijevic, N., Jungblut, P.R., Lamer, S., Rabes, H.M. Electrophoresis (2001)
- Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone. Weber, E., Moore, M.A., Bannasch, P. Carcinogenesis (1988)
- Endogenous incorporation of nitric oxide from L-arginine into N-nitrosomorpholine stimulated by Escherichia coli lipopolysaccharide in the rat. Leaf, C.D., Wishnok, J.S., Tannenbaum, S.R. Carcinogenesis (1991)
- Bacterial formation of N-nitroso compounds from administered precursors in the rat stomach after omeprazole-induced achlorhydria. Calmels, S., Béréziat, J.C., Ohshima, H., Bartsch, H. Carcinogenesis (1991)
- Urinary markers for exposures to alkylating or nitrosating agents. Wishnok, J.S., Tannenbaum, S.R., Stillwell, W.G., Glogowski, J.A., Leaf, C.D. Environ. Health Perspect. (1993)
- Separation in distinct subpopulations by elutriation of liver cells following exposure of rats to N-nitrosomorpholine. Wanson, J.C., Bernaert, D., Penasse, W., Mosselmans, R., Bannasch, P. Cancer Res. (1980)
- Kinetic analysis of the fate of nitric oxide synthesized by macrophages in vitro. Lewis, R.S., Tamir, S., Tannenbaum, S.R., Deen, W.M. J. Biol. Chem. (1995)
- Transfer of bcl-xs plasmid is effective in preventing and inhibiting rat hepatocellular carcinoma induced by N-nitrosomorpholine. Baba, M., Iishi, H., Tatsuta, M. Gene Ther. (2001)
- Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by single oral exposures to N-nitrosomorpholine. Weber, E., Bannasch, P. Carcinogenesis (1994)
- Accumulation of p53 protein in chemically induced oval cells during early stages of rodent hepatocarcinogenesis. Wirnitzer, U., Enzmann, H., Rosenbruch, M., Bomhard, E.M. Carcinogenesis (1995)
- Absence of volatile nitrosamines in human feces. Lee, L., Archer, M.C., Bruce, W.R. Cancer Res. (1981)
- Sequential morphologic alterations in the bronchial epithelium of Syrian golden hamsters during N-nitrosomorpholine-induced pulmonary tumorigenesis. Reznik-Schüller, H. Am. J. Pathol. (1977)
- Quantitative analysis of tumor initiation in rat liver: role of cell replication and cell death (apoptosis). Grasl-Kraupp, B., Luebeck, G., Wagner, A., Löw-Baselli, A., de Gunst, M., Waldhör, T., Moolgavkar, S., Schulte-Hermann, R. Carcinogenesis (2000)
- Endogenous formation of N-nitrosomorpholine in mice from 15NO2 by inhalation and morpholine by gavage. Van Stee, E.W., Sloane, R.A., Simmons, J.E., Moorman, M.P., Brunnemann, K.D. Carcinogenesis (1995)
- A sensitive method for detecting in vivo formation of N-nitrosomorpholine and its application to rats given low doses of morpholine and sodium nitrite. Hecht, S.S., Morrison, J.B. Cancer Res. (1984)
- In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W., Schulte-Hermann, R. Hepatology (1995)
- Rat hepatocarcinogenesis induced by N-nitrosodiethylamine and N-nitrosomorpholine continuously administered at low doses. From basophilic areas of hepatocytes to hepatocellular tumors. Cortinovis, C., Klimek, F., Nogueira, E. Am. J. Pathol. (1991)
- Differential expression of key enzymes of energy metabolism in preneoplastic and neoplastic rat liver lesions induced by N-nitrosomorpholine and dehydroepiandrosterone. Mayer, D., Metzger, C., Leonetti, P., Beier, K., Benner, A., Bannasch, P. Int. J. Cancer (1998)
- Enhancement by isoproterenol of hepatocarcinogenesis induced by N-nitrosomorpholine in Sprague-Dawley rats. Uehara, H., Nakaizumi, A., Baba, M., Iishi, H., Tatsuta, M. Int. J. Cancer (1993)
- Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. Fujita, K., Kamataki, T. Environ. Mol. Mutagen. (2001)
- Role of transforming growth factor alpha and prostaglandins in preferential growth of preneoplastic rat hepatocytes. Hufnagl, K., Parzefall, W., Marian, B., Käfer, M., Bukowska, K., Schulte-Hermann, R., Grasl-Kraupp, B. Carcinogenesis (2001)
- Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes. Masui, T., Nakanishi, H., Inada, K., Imai, T., Mizoguchi, Y., Yada, H., Futakuchi, M., Shirai, T., Tatematsu, M. Cancer Lett. (1997)
- Overexpression of insulin receptor substrate-1 emerges early in hepatocarcinogenesis and elicits preneoplastic hepatic glycogenosis. Nehrbass, D., Klimek, F., Bannasch, P. Am. J. Pathol. (1998)
- Inhibition by somatostatin of hepatocarcinogenesis induced by N-nitrosomorpholine in Sprague-Dawley rats. Nakaizumi, A., Uehara, H., Baba, M., Iishi, H., Tatsuta, M. Carcinogenesis (1993)
- Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate. Weşierska-Gadek, J., Bugajska-Schretter, A., Löw-Baselli, A., Grasl-Kraupp, B. Mol. Carcinog. (1999)
- Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model. Futakuchi, M., Hirose, M., Ogiso, T., Kato, K., Sano, M., Ogawa, K., Shirai, T. Jpn. J. Cancer Res. (1999)