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Chemical Compound Review

Cadox     2-methyl-2-tert-butylperoxy- propane

Synonyms: DTBP, t-BuOOH, Kayabutyl D, Perbutyl D, Trigonox B, ...
 
 
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Disease relevance of t-Butyl peroxide

 

High impact information on t-Butyl peroxide

  • Surprisingly, transcriptional fusion analysis indicated that BosR exerted a positive regulatory effect on napA that is inducible with t-butyl peroxide [1].
  • Indeed, anthracycline-pretreated myocytes become more susceptible to the low-level oxidative stress imposed by repetitive additions of tert-butyl peroxide [3].
  • Ultraviolet light-induced free radical alkylation with 2-propanol or D-ribose, initiated with di-tert-butyl peroxide, of poly (G), poly (U20G), and poly(A) led to the substitution of the appropriate group for the H-8 atom of the purines and addition across the 5,6-double bond of the pyrimidines [4].
  • On the other hand, spontaneous and oxidative (addition of tert-butylperoxide) stress-induced eryptosis was significantly larger in neonatal erythrocytes [5].
  • The transient absorption spectra obtained after laser flash photolysis in the presence of di-tert-butyl peroxide showed the features of benzylic radicals with formation and decay kinetics not significantly influenced by the presence of oxygen [6].
 

Biological context of t-Butyl peroxide

 

Anatomical context of t-Butyl peroxide

  • Human liver microsomes supplemented with NADPH generated the dihydroisoquinolinium ion metabolite along with other hydroxylated metabolites, whereas when supplemented with t-butyl peroxide, only the dihydroisoquinolinium ion metabolite was observed [10].
 

Associations of t-Butyl peroxide with other chemical compounds

 

Gene context of t-Butyl peroxide

  • Overexpression of PGHS1 strongly potentiated NF-kappa B activation by phorbol esters and dramatically elevated the generation of intracellular reactive oxygen species (ROS) in response to low concentrations of t-butyl peroxide [13].
 

Analytical, diagnostic and therapeutic context of t-Butyl peroxide

  • Through selective thermal decomposition of the initiator TBPO, films with well-defined chemical structures and full functionality retention can be deposited, which is evident in the Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses [14].

References

  1. Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activator. Boylan, J.A., Posey, J.E., Gherardini, F.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Comparison of the skin tumor-promoting potential of different organic peroxides in SENCAR mice. Gimenez-Conti, I.B., Binder, R.L., Johnston, D., Slaga, T.J. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  3. Inhibition of membrane-associated calcium-independent phospholipase A2 as a potential culprit of anthracycline cardiotoxicity. Swift, L., McHowat, J., Sarvazyan, N. Cancer Res. (2003) [Pubmed]
  4. Light-induced free radical alkylation of polynucleotides and their enzymatic digestion. Leonov, D., Elad, D. Nucleic Acids Res. (1977) [Pubmed]
  5. Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes. Hermle, T., Shumilina, E., Attanasio, P., Akel, A., Kempe, D.S., Lang, P.A., Podolski, M., Gatz, S., Bachmann, R., Bachmann, C., Abele, H., Huber, S., Wieder, T., Lang, F. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  6. Benzo[d]-1,2-oxaphospholes as precursors of stabilized C-centered radicals. Pérez-Prieto, J., Galian, R.E., Miranda, M.A., Catalina, F., Martín-Vargas, N., López-Ortiz, F. Org. Lett. (2004) [Pubmed]
  7. Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population. Lahiri, D.K., Xu, Y., Klaunig, J., Baiyewu, O., Ogunniyi, A., Hall, K., Hendrie, H., Sahota, A. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  8. Free-radical scavenging by Ouratea parviflora in experimentally-induced liver injuries. Carbonari, K.A., Ferreira, E.A., Rebello, J.M., Felipe, K.B., Rossi, M.H., Felício, J.D., Filho, D.W., Yunes, R.A., Pedrosa, R.C. Redox Rep. (2006) [Pubmed]
  9. Heating unsaturated fatty acids in air produces hemagglutinins. Patrikios, I.S., Britton, O., Bing, D.K., Russell, C.S. Biochim. Biophys. Acta (1994) [Pubmed]
  10. Metabolism of nomifensine to a dihydroisoquinolinium ion metabolite by human myeloperoxidase, hemoglobin, monoamine oxidase A, and cytochrome P450 enzymes. Obach, R.S., Dalvie, D.K. Drug Metab. Dispos. (2006) [Pubmed]
  11. Reactivity of alkyl versus silyl peroxides. The consequences of 1, 2-silicon bridging on the epoxidation of alkenes with silyl hydroperoxides and bis(trialkylsilyl)peroxides. Estévez, C.M., Dmitrenko, O., Winter, J.E., Bach, R.D. J. Org. Chem. (2000) [Pubmed]
  12. Kinetics and mechanism of gas-phase thermolysis using headspace-gas chromatographic analysis. Cafferata, L.F., Manzione, C.J. Journal of chromatographic science. (2001) [Pubmed]
  13. Novel intracellular signaling function of prostaglandin H synthase-1 in NF-kappa B activation. Munroe, D.G., Wang, E.Y., MacIntyre, J.P., Tam, S.S., Lee, D.H., Taylor, G.R., Zhou, L., Plante, R.K., Kazmi, S.M., Bäuerle, P.A. J. Inflamm. (1995) [Pubmed]
  14. Initiated chemical vapor deposition of linear and cross-linked poly(2-hydroxyethyl methacrylate) for use as thin-film hydrogels. Chan, K., Gleason, K.K. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
 
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