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Chemical Compound Review

Azahexan     pentan-1-amine

Synonyms: Amylamine, azahexane, Pentylamine, Norleucamine, Monoamylamine, ...
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Disease relevance of N-AMYLAMINE

  • Butylamine and pentylamine derivatives of PSMA copolymers exhibited more than 80% hemolysis at endosomal pH values, which suggests their potential as a platform of "smart" polymeric carriers for enhanced cytoplasmic delivery of a variety of therapeutic macromolecules [1].
  • Expression of transglutaminase activity in the A375 and A2058 human melanoma cell extracts was revealed by its ability to induce galectin-3 oligomerization and 5-(biotinamido) pentylamine incorporation [2].

Psychiatry related information on N-AMYLAMINE


High impact information on N-AMYLAMINE


Chemical compound and disease context of N-AMYLAMINE


Biological context of N-AMYLAMINE


Anatomical context of N-AMYLAMINE

  • Liver microsomes (0.3-0.6 mg protein) were incubated (15 min, 23 degrees C) with 0.4 mg MAb and, after adding NMAA to 6 mM, incubated for 20 min at 37 degrees C. Mixtures were analysed for HO-NMAAs by gas chromatography-thermal energy analysis and for aldehydes by high-performance liquid chromatography of their 2,4-dinitrophenylhydrazones [10].
  • Because of the large mass of skeletal muscle compared with liver, it is considered that the changes in muscle MAO could play an important role in determining the rate of oxidation of pentylamine in vivo [11].

Associations of N-AMYLAMINE with other chemical compounds


Gene context of N-AMYLAMINE


Analytical, diagnostic and therapeutic context of N-AMYLAMINE


  1. pH-responsive poly(styrene-alt-maleic anhydride) alkylamide copolymers for intracellular drug delivery. Henry, S.M., El-Sayed, M.E., Pirie, C.M., Hoffman, A.S., Stayton, P.S. Biomacromolecules (2006) [Pubmed]
  2. Transglutaminase-mediated oligomerization of galectin-3 modulates human melanoma cell interactions with laminin. van den Brûle, F.A., Liu, F.T., Castronovo, V. Cell Adhes. Commun. (1998) [Pubmed]
  3. n-Pentylamine: effect on motor activity of mice. Widy-Tyszkiewicz, E., Sourkes, T.L. Pharmacol. Biochem. Behav. (1980) [Pubmed]
  4. In vitro modification of betaine-homocysteine S-methyltransferase by tissue-type transglutaminase. Ichikawa, A., Ohashi, Y., Terada, S., Natsuka, S., Ikura, K. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  5. A new method for the routine spreading of DNA in protein-free conditions. Bratosin-Guttman, S. J. Struct. Biol. (1992) [Pubmed]
  6. Identification of amine acceptor protein substrates of transglutaminase in liver extracts: use of 5-(biotinamido) pentylamine as a probe. Ikura, K., Kita, K., Fujita, I., Hashimoto, H., Kawabata, N. Arch. Biochem. Biophys. (1998) [Pubmed]
  7. Immobilization of streptavidin-horseradish peroxidase onto a biotinylated poly(acrylic acid) backbone that had been radiation-grafted to a PTFE film. Sadurní, P., Alagón, A., Aliev, R., Burillo, G., Hoffman, A.S. Journal of biomaterials science. Polymer edition. (2005) [Pubmed]
  8. The deamination of n-pentylamine by monoamine oxidase and a semicarbazide-sensitive amine oxidase of rat heart. Guffroy, C., Fowler, C.J., Strolin Benedetti, M. J. Pharm. Pharmacol. (1983) [Pubmed]
  9. Effect of aliphatic monoamines on motor activity of mice: no direct interaction with dopaminergic D2 receptor. Widy-Tyszkiewicz, E., Członkowski, A. Polish journal of pharmacology and pharmacy. (1983) [Pubmed]
  10. Use of monoclonal antibodies to identify cytochrome P450 isozymes in rat liver microsomes that hydroxylate N-nitrosomethylamylamine at each of six positions. Mirvish, S.S., Ji, C., Huang, Q., Wang, S., Park, S.S., Gelboin, H.V. IARC Sci. Publ. (1991) [Pubmed]
  11. Metabolism of monoamines and diamines in hyperthyroid and hypothyroid rats. Sourkes, T.L., Missala, K., Bastomsky, C.H., Fang, T.Y. Can. J. Biochem. (1977) [Pubmed]
  12. Probing mechanisms of catalysis and electron transfer by methylamine dehydrogenase by site-directed mutagenesis of alpha Phe55. Davidson, V.L. Biochim. Biophys. Acta (2003) [Pubmed]
  13. Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients. Maurer-Spurej, E., Wong, K.F., Maurer, N., Fenske, D.B., Cullis, P.R. Biochim. Biophys. Acta (1999) [Pubmed]
  14. Metabolism of the oesophageal carcinogen N-nitrosomethylamylamine: changes with age, clearance from blood and DNA alkylation. Mirvish, S.S., Ji, C., Makary, M., Schut, H.A., Krokos, C. IARC Sci. Publ. (1987) [Pubmed]
  15. Ammonia blockade of intestinal epithelial K+ conductance. Hrnjez, B.J., Song, J.C., Prasad, M., Mayol, J.M., Matthews, J.B. Am. J. Physiol. (1999) [Pubmed]
  16. Action of inhibitors on monoamine and diamine metabolism in the rat. Sourkes, T.L., Missala, K. Can. J. Biochem. (1977) [Pubmed]
  17. Detection of the amine acceptor protein substrates of transglutaminase with 5-(biotinamido) pentylamine. Singh, R.N., McQueen, T., Mehta, K. Anal. Biochem. (1995) [Pubmed]
  18. Simple analysis of four bisphosphonates simultaneously by reverse phase liquid chromatography using n-amylamine as volatile ion-pairing agent. Xie, Z., Jiang, Y., Zhang, D.Q. Journal of chromatography. A. (2006) [Pubmed]
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