Disease relevance of N-AMYLAMINE

• Butylamine and pentylamine derivatives of PSMA copolymers exhibited more than 80% hemolysis at endosomal pH values, which suggests their potential as a platform of "smart" polymeric carriers for enhanced cytoplasmic delivery of a variety of therapeutic macromolecules [1].
• Expression of transglutaminase activity in the A375 and A2058 human melanoma cell extracts was revealed by its ability to induce galectin-3 oligomerization and 5-(biotinamido) pentylamine incorporation [2].

Psychiatry related information on N-AMYLAMINE

• n-Pentylamine: effect on motor activity of mice [3].

High impact information on N-AMYLAMINE

• Guinea pig liver transglutaminase incorporated 5-(biotinamido) pentylamine and [3H] histamine into BHMT in a time-dependent manner [4].
• The established and currently popular technique of spreading DNA on carbon membranes treated by glow discharge in an atmosphere of pentylamine is limited with regard to its reproducibility and the proper distribution of spread molecules on the surface of the membranes [5].
• Identification of amine acceptor protein substrates of transglutaminase in liver extracts: use of 5-(biotinamido) pentylamine as a probe [6].
• Carboxylic groups of the grafted polyAAc were activated with carbodiimide (EDC) for biotinylation by reaction with 5-(biotinamido) pentylamine [7].
• The deamination of n-pentylamine by monoamine oxidase and a semicarbazide-sensitive amine oxidase of rat heart [8].

Chemical compound and disease context of N-AMYLAMINE

• Depression of locomotor activity produced by combined treatment with alpha-methyl-tyrosine, reserpine and dopa was counteracted by pentylamine and hexylamine; they did not produce such an effect in the absence of dopa [9].

Biological context of N-AMYLAMINE

• Inhibition of enzyme activity by monoclonal antibodies (MAbs) was used to indicate which cytochrome P450 isozymes in Sprague-Dawley rat liver microsomes catalyse hydroxylation of the oesophageal carcinogen N-nitrosomethyl-n-amylamine (NMAA) to give 2- to 5-hydroxy-NMAA (HO-NMAA), formaldehyde and pentaldehyde [10].

Anatomical context of N-AMYLAMINE

• Liver microsomes (0.3-0.6 mg protein) were incubated (15 min, 23 degrees C) with 0.4 mg MAb and, after adding NMAA to 6 mM, incubated for 20 min at 37 degrees C. Mixtures were analysed for HO-NMAAs by gas chromatography-thermal energy analysis and for aldehydes by high-performance liquid chromatography of their 2,4-dinitrophenylhydrazones [10].
• Because of the large mass of skeletal muscle compared with liver, it is considered that the changes in muscle MAO could play an important role in determining the rate of oxidation of pentylamine in vivo [11].

Associations of N-AMYLAMINE with other chemical compounds

• Site-directed mutagenesis of either alpha Phe(55) or beta Ile(107) (a residue in the beta subunit which interacts with alpha Phe(55)) converts MADH into enzymes with specificities for long-chain amines, amylamine or propylamine [12].
• It is shown that entrapment of increasingly hydrophobic monoamines (methylamine to amylamine) all lead to an induced DeltapH of 3 units and essentially complete drug uptake under the conditions employed, but do not lead to improved retention of vincristine and ciprofloxacin [13].
• Incubation of adult oesophagus and liver slices with 3H-labelled NMAA produced DNA labelling, including labelled N7-and O6-methylguanine, with 14 times higher specific radioactivity in DNA from oesophagus than from liver [14].
• We defined the target of ammonia action by structure-function analysis with a series of primary amines (ammonia, methylamine, ethylamine, propylamine, butylamine, pentylamine, hexylamine, heptylamine, and octylamine) that vary principally in size and lipid solubilities [15].
• The effects of a series of inhibitors of monoamine oxidase (EC 1.4.3.4) and diamine oxidase (EC 1.4.3.6) and of two chelating agents were studied in rats, with respect to the catabolism of labeled pentylamine and putrescine to radioactive carbon dioxide [16].

Gene context of N-AMYLAMINE

• Detection of the amine acceptor protein substrates of transglutaminase with 5-(biotinamido) pentylamine [17].

Analytical, diagnostic and therapeutic context of N-AMYLAMINE

• Simple analysis of four bisphosphonates simultaneously by reverse phase liquid chromatography using n-amylamine as volatile ion-pairing agent [18].
• There was no effect of hypophysectomy on the rate of pentylamine oxidation [11].

References