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Aoc3  -  amine oxidase, copper containing 3

Rattus norvegicus

Synonyms: Copper amine oxidase, Membrane primary amine oxidase, SSAO, Semicarbazide-sensitive amine oxidase, VAP-1, ...
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Disease relevance of Aoc3


High impact information on Aoc3


Chemical compound and disease context of Aoc3


Biological context of Aoc3


Anatomical context of Aoc3


Associations of Aoc3 with chemical compounds


Regulatory relationships of Aoc3

  • Interleukin-1-beta (IL-1beta) can promote inflammation by up-regulating vascular adhesion molecules and inhibit inflammation by activating the hypothalamic-pituitary-adrenal (HPA) axis to produce anti-inflammatory glucocorticoids [22].

Other interactions of Aoc3


Analytical, diagnostic and therapeutic context of Aoc3


  1. Rat cytomegalovirus infection in kidney allograft recipients is associated with increased expression of intracellular adhesion molecule-1 vascular adhesion molecule-1, and their ligands leukocyte function antigen-1 and very late antigen-4 in the graft. Kloover, J.S., Soots, A.P., Krogerus, L.A., Kauppinen, H.O., Loginov, R.J., Holma, K.L., Bruggeman, C.A., Ahonen, P.J., Lautenschlager, I.T. Transplantation (2000) [Pubmed]
  2. Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide. Vidrio, H., Medina, M., González-Romo, P., Lorenzana-Jiménez, M., Díaz-Arista, P., Baeza, A. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  3. Developmental vasculotoxicity associated with inhibition of semicarbazide-sensitive amine oxidase. Langford, S.D., Trent, M.B., Balakumaran, A., Boor, P.J. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  4. Selective overexpression of inflammatory molecules in hearts from brain-dead rats. Segel, L.D., vonHaag, D.W., Zhang, J., Follette, D.M. J. Heart Lung Transplant. (2002) [Pubmed]
  5. Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase. Boor, P.J., Trent, M.B., Lyles, G.A., Tao, M., Ansari, G.A. Toxicology (1992) [Pubmed]
  6. Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis. Körner, H., Goodsall, A.L., Lemckert, F.A., Scallon, B.J., Ghrayeb, J., Ford, A.L., Sedgwick, J.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Vascular adhesion molecule-1 and intercellular adhesion molecule-1 expression on rat liver cells after lipopolysaccharide administration in vivo. van Oosten, M., van de Bilt, E., de Vries, H.E., van Berkel, T.J., Kuiper, J. Hepatology (1995) [Pubmed]
  8. Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection. Martelius, T., Salaspuro, V., Salmi, M., Krogerus, L., Höckerstedt, K., Jalkanen, S., Lautenschlager, I. Am. J. Pathol. (2004) [Pubmed]
  9. Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. Souto, R.P., Vallega, G., Wharton, J., Vinten, J., Tranum-Jensen, J., Pilch, P.F. J. Biol. Chem. (2003) [Pubmed]
  10. Combined treatment with benzylamine and low dosages of vanadate enhances glucose tolerance and reduces hyperglycemia in streptozotocin-induced diabetic rats. Marti, L., Abella, A., Carpéné, C., Palacín, M., Testar, X., Zorzano, A. Diabetes (2001) [Pubmed]
  11. Semicarbazide protection from in vivo oxidant injury of vascular tissue by allylamine. Awasthi, S., Boor, P.J. Toxicol. Lett. (1993) [Pubmed]
  12. 2-bromoethylamine, a suicide inhibitor of semicarbazide-sensitive amine oxidase, increases hydralazine hypotension in rats. Vidrio, H., Medina, M. J. Cardiovasc. Pharmacol. (2005) [Pubmed]
  13. The role of plasma semicarbazide-sensitive amine oxidase in allylamine and beta-aminopropionitrile cardiovascular toxicity: mechanisms of myocardial protection and aortic medial injury in rats. Conklin, D.J., Trent, M.B., Boor, P.J. Toxicology (1999) [Pubmed]
  14. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Gong, B., Trent, M.B., Srivastava, D., Boor, P.J. Birth Defects Res. Part A Clin. Mol. Teratol. (2006) [Pubmed]
  15. Simultaneous determination of formaldehyde and methylglyoxal in urine: involvement of semicarbazide-sensitive amine oxidase-mediated deamination in diabetic complications. Deng, Y., Yu, P.H. Journal of chromatographic science. (1999) [Pubmed]
  16. Molecular cloning and characterization of rat semicarbazide-sensitive amine oxidase. Ochiai, Y., Itoh, K., Sakurai, E., Tanaka, Y. Biol. Pharm. Bull. (2005) [Pubmed]
  17. Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Ellerman, K.E., Like, A.A. Diabetologia (2000) [Pubmed]
  18. A new role for monoamine oxidases in the modulation of macrophage-inducible nitric oxide synthase gene expression. Vega, A., Chacón, P., Monteseirín, J., El Bekay, R., Alvarez, M., Alba, G., Conde, J., Martín-Nieto, J., Bedoya, F.J., Pintado, E., Sobrino, F. J. Leukoc. Biol. (2004) [Pubmed]
  19. Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells. Enrique-Tarancón, G., Marti, L., Morin, N., Lizcano, J.M., Unzeta, M., Sevilla, L., Camps, M., Palacín, M., Testar, X., Carpéné, C., Zorzano, A. J. Biol. Chem. (1998) [Pubmed]
  20. High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent. Park, C.W., Kim, J.H., Lee, J.H., Kim, Y.S., Ahn, H.J., Shin, Y.S., Kim, S.Y., Choi, E.J., Chang, Y.S., Bang, B.K., Lee, J.W. Diabetologia (2000) [Pubmed]
  21. The interaction of hydralazine with a semicarbazide-sensitive amine oxidase in brown adipose tissue of the rat. Its use as a radioactive ligand for the enzyme. Barrand, M.A., Callingham, B.A. Biochem. J. (1985) [Pubmed]
  22. Chronic morphine potentiates the inflammatory response by disrupting interleukin-1beta modulation of the hypothalamic-pituitary-adrenal axis. House, S.D., Mao, X., Wu, G., Espinelli, D., Li, W.X., Chang, S.L. J. Neuroimmunol. (2001) [Pubmed]
  23. Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. I. Inhibition by a selective monoamine oxidase-B inhibitor, MD 780236. Kinemuchi, H., Morikawa, F., Ueda, T., Arai, Y. Jpn. J. Pharmacol. (1986) [Pubmed]
  24. Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis. Polfliet, M.M., Zwijnenburg, P.J., van Furth, A.M., van der Poll, T., Döpp, E.A., Renardel de Lavalette, C., van Kesteren-Hendrikx, E.M., van Rooijen, N., Dijkstra, C.D., van den Berg, T.K. J. Immunol. (2001) [Pubmed]
  25. A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates. Holt, A., Sharman, D.F., Baker, G.B., Palcic, M.M. Anal. Biochem. (1997) [Pubmed]
  26. Inhibition of monoamine oxidase A-form and semicarbazide-sensitive amine oxidase by selective and reversible monoamine oxidase-A inhibitors, amiflamine and FLA 788(+). Morikawa, F., Ueda, T., Arai, Y., Kinemuchi, H. Pharmacology (1986) [Pubmed]
  27. Semicarbazide-sensitive amine oxidase and extracellular matrix deposition by smooth-muscle cells. Langford, S.D., Trent, M.B., Boor, P.J. Cardiovasc. Toxicol. (2002) [Pubmed]
  28. Solubilization and some properties of a semicarbazide-sensitive amine oxidase in brown adipose tissue of the rat. Barrand, M.A., Callingham, B.A. Biochem. J. (1984) [Pubmed]
  29. The influence of amine metabolizing enzymes on the pharmacology of tyramine in the isolated perfused mesenteric arterial bed of the rat. Elliott, J., Callingham, B.A., Sharman, D.F. Br. J. Pharmacol. (1989) [Pubmed]
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