Disease relevance of Bergamol

• Detection of a new enzyme for stereoselective hydrolysis of linalyl acetate using simple plate assays for the characterization of cloned esterases from Burkholderia gladioli [1].
• The effects of equi-molar doses of linalyl acetate on local edema were less relevant and more delayed than that of the corresponding alcohol [2].

High impact information on Bergamol

• Taken together, our findings lead us to speculate that the antimicrobial effect of (+)menthol, thymol, and linalyl acetate may result, at least partially, from a perturbation of the lipid fraction of microorganism plasma membrane, resulting in alterations of membrane permeability and in leakage of intracellular materials [3].
• Carboxylesterases containing the sequence motif GGGX catalyze the hydrolysis of esters of chiral tertiary alcohols, albeit with only low to moderate enantioselectivity, for three model substrates (linalyl acetate, methyl-1-pentin-1-yl acetate, 2-phenyl-3-butin-2-yl acetate) [4].
• The purpose of the study was to investigete skin absorption and elimination of three acyclic terpenes: citronellol (C), linalool (L) and linalyl acetate (LA) [5].
• Lavandula angustifolia Hidcote species, which contains a higher level of linalyl acetate and linalool but little camphor, was evaluated as the highest quality among the four different Lavandula species [6].
• Furthermore, suppression of the phenylephrine-induced contraction and MLC phosphorylation with linalyl acetate was canceled by the pretreatment with calyculin A [7].

Biological context of Bergamol

• The use of 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS-) esters and linalyl acetate for these assays clearly allowed to discriminate substrate specificities for two different cloned esterases, EP6 and EP10 [1].
• The drug release kinetics of two substances, LLA and BZC, are observed, in showing a burst effect, then a diffusion process, which can be modelled assuming that the particles are homogeneous spheres [8].

Anatomical context of Bergamol

• Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain [7].
• Thus, the present experiments were designed to investigate the relaxation mechanism of linalyl acetate as the major ingredient of lavender essential oil in rabbit carotid artery specimens [7].
• The relaxation effect of linalyl acetate at a concentration near the EC50 was partially but significantly attenuated by nitroarginine as an inhibitor of nitric oxide synthase, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one as an inhibitor of guanylyl cyclase, or by the denudation of endothelial cells [7].
• In specimens without endothelium, the phenylephrine-induced contraction and phosphorylation of myosin light chain (MLC) were significantly attenuated after the pretreatment with linalyl acetate [7].

Associations of Bergamol with other chemical compounds

• These results suggest that linalyl acetate relaxes the vascular smooth muscle through partially activation of nitric oxide/cyclic guanosine monophosphate pathway, and partially MLC dephosphorylation via activating MLC phosphatase [7].
• We examined the effects of linalool, linalyl acetate, borneol, camphene, cineol, terpinen-4-ol, alpha-pinene and beta-myrcene using the Geller and Vogel conflict tests in ICR mice [9].
• Lavandula angustifolia Miller essential oil and some of its main constituents, i.e. linalool, linalyl acetate, and camphor were tested in vitro for their bioactivities against Psoroptes cuniculi (Delafond, 1859), mite of the rabbit [10].

Gene context of Bergamol

• The biovariability of Citrus bergamia grown wild in Calabria (Italy) was investigated as far as chemical markers (linalool, linalyl acetate and bergapten) content and antioxidant and antifungal activities of the methanolic extracts [11].

References