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Disease relevance of Citrus

  • D-Limonene and the citrus fruit oils given p.o. 1 h prior to NNK, also administered p.o., inhibited pulmonary adenoma formation and the occurrence of forestomach tumors [1].
  • A series of viroids and viroid-like RNAs extracted from citron (Citrus medica), grapevine (Vitis vinifera), and avocado (Persea americanum) displayed differential binding capacities to cellulose in the presence of ethanol [2].
  • BACKGROUND: Recent investigations have demonstrated that the citrus red mite (Panonychus citri, CRM) is the most important allergen in citrus fruit farmers with asthma and rhinitis and a common sensitizing allergen in children living near citrus orchards [3].
  • Total tooth loss and prevalent cardiovascular disease in men and women: possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables [4].

High impact information on Citrus

  • Modified citrus pectin (pH-modified), a soluble component of plant fiber derived from citrus fruit, has been shown to interfere with cell-cell interactions mediated by cell surface carbohydrate-binding galectin-3 molecules [5].
  • Ethylene appears to enhance the degreening of citrus fruit through de novo synthesis of the Chlase protein, which in turn is inhibited by the senescence-delaying regulators, gibberellin A3 and N6-benzyladenine [6].
  • AA alone and in citrus fruit medium decreased erythrocyte sorbitol 12.6 and 27.2%, respectively, with the latter being significantly more effective [7].
  • It is unknown whether pomelo, a closely related citrus fruit, interacts with cyclosporine in humans [8].
  • Accumulation of carotenoids and expression of carotenoid biosynthetic genes during maturation in citrus fruit [9].

Chemical compound and disease context of Citrus


Biological context of Citrus


Anatomical context of Citrus


Associations of Citrus with chemical compounds


Gene context of Citrus


Analytical, diagnostic and therapeutic context of Citrus


  1. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils. Wattenberg, L.W., Coccia, J.B. Carcinogenesis (1991) [Pubmed]
  2. Separation of viroid RNAs by cellulose chromatography indicating conformational distinctions. Semancik, J.S. Virology (1986) [Pubmed]
  3. Relationship between sensitization to citrus red mite (Panonychus citri) and the prevalence of atopic diseases in adolescents living near citrus orchards. Kim, S.H., Kim, Y.K., Lee, M.H., Hong, S.C., Bae, J.M., Min, K.U., Kim, Y.Y., Cho, S.H. Clin. Exp. Allergy (2002) [Pubmed]
  4. Total tooth loss and prevalent cardiovascular disease in men and women: possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables. Lowe, G., Woodward, M., Rumley, A., Morrison, C., Tunstall-Pedoe, H., Stephen, K. Journal of clinical epidemiology. (2003) [Pubmed]
  5. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. Pienta, K.J., Naik, H., Akhtar, A., Yamazaki, K., Replogle, T.S., Lehr, J., Donat, T.L., Tait, L., Hogan, V., Raz, A. J. Natl. Cancer Inst. (1995) [Pubmed]
  6. Ethylene induces de novo synthesis of chlorophyllase, a chlorophyll degrading enzyme, in Citrus fruit peel. Trebitsh, T., Goldschmidt, E.E., Riov, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. In vitro and in vivo reduction of erythrocyte sorbitol by ascorbic acid. Vinson, J.A., Staretz, M.E., Bose, P., Kassm, H.M., Basalyga, B.S. Diabetes (1989) [Pubmed]
  8. Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Grenier, J., Fradette, C., Morelli, G., Merritt, G.J., Vranderick, M., Ducharme, M.P. Clin. Pharmacol. Ther. (2006) [Pubmed]
  9. Accumulation of carotenoids and expression of carotenoid biosynthetic genes during maturation in citrus fruit. Kato, M., Ikoma, Y., Matsumoto, H., Sugiura, M., Hyodo, H., Yano, M. Plant Physiol. (2004) [Pubmed]
  10. A rapid and sensitive dot-blot hybridization assay for the detection of citrus exocortis viroid in Citrus medica with digoxigenin-labelled RNA probes. Fonseca, M.E., Marcellino, L.H., Gander, E. J. Virol. Methods (1996) [Pubmed]
  11. Analysis of sucrose synthase genes in citrus suggests different roles and phylogenetic relationships. Komatsu, A., Moriguchi, T., Koyama, K., Omura, M., Akihama, T. J. Exp. Bot. (2002) [Pubmed]
  12. Inhibitors of platelet lipoxygenase from Ponkan fruit. Nogata, Y., Sekiya, K., Ohta, H., Kusumoto, K., Ishizu, T. Phytochemistry (2001) [Pubmed]
  13. Sucrose activation of mitosis in lemon fruit explants (Citrus limon L.). Kordan, H.A. Experientia (1977) [Pubmed]
  14. Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells. Ogata, S., Miyake, Y., Yamamoto, K., Okumura, K., Taguchi, H. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  15. Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice. Tanaka, T., Sugiura, H., Inaba, R., Nishikawa, A., Murakami, A., Koshimizu, K., Ohigashi, H. Carcinogenesis (1999) [Pubmed]
  16. Modulation of digoxin transport across Caco-2 cell monolayers by citrus fruit juices: lime, lemon, grapefruit, and pummelo. Xu, J., Go, M.L., Lim, L.Y. Pharm. Res. (2003) [Pubmed]
  17. The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice. Minagawa, A., Otani, Y., Kubota, T., Wada, N., Furukawa, T., Kumai, K., Kameyama, K., Okada, Y., Fujii, M., Yano, M., Sato, T., Ito, A., Kitajima, M. Jpn. J. Cancer Res. (2001) [Pubmed]
  18. Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. Miyazawa, M., Shindo, M., Shimada, T. Xenobiotica (2001) [Pubmed]
  19. Citrus fruit flavor and aroma biosynthesis: isolation, functional characterization, and developmental regulation of Cstps1, a key gene in the production of the sesquiterpene aroma compound valencene. Sharon-Asa, L., Shalit, M., Frydman, A., Bar, E., Holland, D., Or, E., Lavi, U., Lewinsohn, E., Eyal, Y. Plant J. (2003) [Pubmed]
  20. Mechanism of neurotrophic action of nobiletin in PC12D cells. Nagase, H., Yamakuni, T., Matsuzaki, K., Maruyama, Y., Kasahara, J., Hinohara, Y., Kondo, S., Mimaki, Y., Sashida, Y., Tank, A.W., Fukunaga, K., Ohizumi, Y. Biochemistry (2005) [Pubmed]
  21. Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietary and other factors. Hemminki, K., Jiang, Y., Ma, X., Yang, K., Egevad, L., Lindblad, P. Carcinogenesis (2002) [Pubmed]
  22. A non-photosynthetic ferredoxin gene is induced by ethylene in Citrus organs. Alonso, J.M., Chamarro, J., Granell, A. Plant Mol. Biol. (1995) [Pubmed]
  23. Molecular characterization of the mitochondrial citrate synthase gene of an acidless pummelo (Citrus maxima). Canel, C., Bailey-Serres, J.N., Roose, M.L. Plant Mol. Biol. (1996) [Pubmed]
  24. Cloning and molecular analysis of cDNAs encoding three sucrose phosphate synthase isoforms from a citrus fruit (Citrus unshiu Marc.). Komatsu, A., Takanokura, Y., Omura, M., Akihama, T. Mol. Gen. Genet. (1996) [Pubmed]
  25. Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin. Orallo, F., Camiña, M., Alvarez, E., Basaran, H., Lugnier, C. Planta Med. (2005) [Pubmed]
  26. Determination of fenpropimorph in citrus fruit by reversed-phase high-performance liquid chromatography. Tadeo, J.L., Lafuente, M.T. J. Chromatogr. (1987) [Pubmed]
  27. Copper/zinc-superoxide dismutase from lemon cDNA and enzyme stability. Lin, M.W., Lin, M.T., Lin, C.T. J. Agric. Food Chem. (2002) [Pubmed]
  28. Extraction parameters and capillary electrophoresis analysis of limonin glucoside and phlorin in citrus byproducts. Braddock, R.J., Bryan, C.R. J. Agric. Food Chem. (2001) [Pubmed]
  29. Residues analysis of post-harvest imidazole fungicides in citrus fruit by HPLC and GLC. Lafuente, M.T., Tadeo, J.L. International journal of environmental analytical chemistry. (1985) [Pubmed]
  30. A simple method of sample preparation for analysis of biphenyl residues in citrus fruit peels by gas chromatography. Anklam, E., Müller, A. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. (1994) [Pubmed]
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