Disease relevance of LS-678

• Identification and sequencing of beta-myrcene catabolism genes from Pseudomonas sp. strain M1 [1].
• Peri- and postnatal developmental toxicity of beta-myrcene in the rat [2].
• From the data presented in this paper the no-observed-adverse-effect level for embryo-foetotoxicity could be set at 0.5 g beta-myrcene/kg body weight [3].

High impact information on LS-678

• Based on sequence and biotransformation data, we propose a pathway for beta-myrcene catabolism in Pseudomonas sp. strain M1 [1].
• One of the selected cosmids, containing a 22-kb genomic insert, was able to complement the N22 mutant for growth on beta-myrcene [1].
• Influence of beta-myrcene on sister-chromatid exchanges induced by mutagens in V79 and HTC cells [4].
• Gas chromatography analysis of the essential oils of leaves and bark collected from the newly discovered tree Pleodendron costaricense identified alpha-pinene, beta-pinene, beta-myrcene, beta-thujene, and beta-caryophyllene as their major constituents [5].
• The final steps in the pheromone-biosynthetic pathway of the pine engraver beetle, Ips pini (Say) (Coleoptera: Scolytidae) are unknown, but likely involve myrcene (7-methyl-3-methylene-1,6-octadiene) hydroxylation to produce the aggregation pheromone component, ipsdienol (2-methyl-6-methylene-2,7-octadien-4-ol) [6].

Biological context of LS-678

• Absence of genotoxic activity of beta-myrcene in the in vivo cytogenetic bone marrow assay [7].

Anatomical context of LS-678

• These data suggest that beta-myrcene has no benzodiazepine-like anxiolytic activity and that an activity on the central nervous system (antidepressive or antipsychotic) is unlikely [8].

Associations of LS-678 with other chemical compounds

• A gas chromatography flame ionization detection method for the quantification of bioactive marker compounds (neral, geranial, geraniol, limonene, citronellal, and beta-myrcene) in the essential oil of Cymbopogon citratus (lemon grass) was developed [9].
• Metabolites isolated from the urine of rats after oral administration of beta-myrcene (I) were: 10-hydroxylinalool (II), 7-methyl-3-methylene-oct-6-ene-1,2-diol (IV), 1-hydroxymethyl-4-isopropenyl cyclohexanol (VI), 10-carboxylinalool (III) and 2-hydroxy-7-methyl-3-methylene-oct-6-enoic acid (V) [10].
• We examined the effects of linalool, linalyl acetate, borneol, camphene, cineol, terpinen-4-ol, alpha-pinene and beta-myrcene using the Geller and Vogel conflict tests in ICR mice [11].
• Topical applications of linalool, beta-myrcene, or alpha-terpineol at near lethal rates to adult cockroaches before they mated had no significant influence on the reproductive parameters examined [12].
• beta-Myrcene (MYR, 7-methyl-3-methylene-1,6 octadiene) is a peripheral analgesic substance and one of the major constituents of lemongrass oil (Cymbopogon citratus, Stapf), a plant widely used in Brazilian folk medicine [7].

Gene context of LS-678

• The main monoterpene constituents of each oil, beta-myrcene (in PR) and limonene (in CB), were tested in the LPS-induced pleurisy model and assayed also for immunoregulatory activity by measurement of the inhibition of NO and production of the cytokines, gamma-interferon and IL-4 [13].

Analytical, diagnostic and therapeutic context of LS-678

• The chemical structures of the active components were determined on the basis of mass spectrometry linked to gas chromatography, indicating E-beta-ocimene and beta-myrcene as stimulants for neurone type 1, E,E-alpha-farnesene for neurone type 2 and homo-farnesene for neurone type 3 [14].

References