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Chemical Compound Review

Orotidine     3-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: SureCN20894, AG-F-04855, CHEBI:25722, HMDB00788, AC1L3ORG, ...
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Disease relevance of Orotidine


High impact information on Orotidine


Biological context of Orotidine

  • Density functional models of the mechanism for decarboxylation in orotidine decarboxylase [9].
  • All four obligate heterozygotes showed orotic acid and orotidine excretion in excess of 3 S.D. above the control mean and a further 7 women had one or more excretion values in excess of 3 S.D., while 16 gave a value of less than 2 S.D. for both metabolites [10].

Anatomical context of Orotidine


Associations of Orotidine with other chemical compounds


Gene context of Orotidine


Analytical, diagnostic and therapeutic context of Orotidine


  1. Orotidine accumulation in human erythrocytes during allopurinol therapy: association with high urinary oxypurinol-7-riboside concentrations in renal failure and in the Lesch-Nyhan syndrome. Simmonds, H.A., Reiter, S., Davies, P.M., Cameron, J.S. Clin. Sci. (1991) [Pubmed]
  2. Influence of dose and age on the response of the allopurinol test for ornithine carbamoyltransferase deficiency in control infants. Riudor, E., Arranz, J.A., Rodés, M., Rubio, V., Sentís, M., Burlina, A.B. J. Inherit. Metab. Dis. (2000) [Pubmed]
  3. Comparative activity of erythrocyte adenosine deaminase and orotidine decarboxylase in Diamond-Blackfan anemia. Glader, B.E., Backer, K. Am. J. Hematol. (1986) [Pubmed]
  4. Purifications and properties of orotidine-phosphorolyzing enzyme and purine nucleoside phosphorylase from Erwinia carotovora AJ 2992. Shirae, H., Yokozeki, K. Agric. Biol. Chem. (1991) [Pubmed]
  5. Allopurinol-induced orotidinuria. A test for mutations at the ornithine carbamoyltransferase locus in women. Hauser, E.R., Finkelstein, J.E., Valle, D., Brusilow, S.W. N. Engl. J. Med. (1990) [Pubmed]
  6. Isolation and partial characterization of a 5'-nucleotidase specific for orotidine-5'-monophosphate. El Kouni, M.H., Cha, S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  7. Effect of 5-azacytidine on DNA methylation and on the enzymes of de novo pyrimidine biosynthesis in Bacillus subtilis Marburg strain. Guha, S. Eur. J. Biochem. (1984) [Pubmed]
  8. Simultaneous determination of plasma and urinary uric acid, xanthine, hypoxanthine, allopurinol, oxipurinol, orotic acid, orotidine and creatinine by high-performance liquid chromatography. Miyazaki, H., Matsunaga, Y., Yoshida, K., Arakawa, S., Hashimoto, M. J. Chromatogr. (1983) [Pubmed]
  9. Density functional models of the mechanism for decarboxylation in orotidine decarboxylase. Lundberg, M., Blomberg, M.R., Siegbahn, P.E. Journal of molecular modeling (Online) (2002) [Pubmed]
  10. The allopurinol loading test for identification of carriers for ornithine carbamoyl transferase deficiency: studies in a healthy control population and females at risk. Sebesta, I., Fairbanks, L.D., Davies, P.M., Simmonds, H.A., Leonard, J.V. Clin. Chim. Acta (1994) [Pubmed]
  11. Stimulation by 6-azauridine of carbamoyl phosphate synthesis for pyrimidine biosynthesis in mouse spleen slices. Tatibana, M., Kita, K., Asai, T. Eur. J. Biochem. (1982) [Pubmed]
  12. Efficiency of hemodialysis of pyrimidine compounds in patients with chronic renal failure. Daniewska-Michalska, D., Motyl, T., Gellert, R., Kukulska, W., Podgurniak, M., Opechowska-Pacocha, E., Ostrowski, K. Nephron (1993) [Pubmed]
  13. Automated quantitative analysis for orotidine and uridine/thymine in urine by high-performance liquid chromatography with column switching. Kidouchi, K., Nakamura, C., Katoh, T., Kibe, T., Ohba, S., Wada, Y. Adv. Exp. Med. Biol. (1991) [Pubmed]
  14. A reversible selection system for UMP synthase gene amplification and deamplification. Suttle, D.P. Somat. Cell Mol. Genet. (1989) [Pubmed]
  15. Stable yeast transformation with chimeric plasmids using a 2 micron-circular DNA-less strain as a recipient. Blanc, H., Gerbaud, C., Slonimski, P.P., Guérineau, M. Mol. Gen. Genet. (1979) [Pubmed]
  16. Urinary excretion of orotic acid, orotidine and other pyrimidines in a patient with purine nucleoside phosphorylase deficiency. van Gennip, A.H., Grift, J., de Bree, P.K., Zegers, B.J., Stoop, J.W., Wadman, S.K. Clin. Chim. Acta (1979) [Pubmed]
  17. The urinary excretion of orotic acid and orotidine, measured by an isotope dilution assay. Tax, W.J., Veerkamp, J.H., Schretlen, E.D. Clin. Chim. Acta (1978) [Pubmed]
  18. Sequence analysis of the pyr-4 (orotidine 5'-P decarboxylase) gene of Neurospora crassa. Newbury, S.F., Glazebrook, J.A., Radford, A. Gene (1986) [Pubmed]
  19. Metabolic conversion of orotic acid hydrazide into a nucleotide in mouse and rat liver. Krauss, G.J., Grancharov, K., Genchev, D., Walther, R., Spassovska, N., Karamanov, G., Reinbothe, H., Golovinsky, E. Biomed. Biochim. Acta (1983) [Pubmed]
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