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Chemical Compound Review

Vidaza     4-amino-1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Mylosar, Azacitidine, Azacytidine, NSC-102816, NSC102816, ...
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Disease relevance of Azacitidine


High impact information on Azacitidine

  • These results indicate that an azacytidine-induced structural modification (presumably demethylation) in the DNA of a single locus is sufficient to convert 10T1/2 cells into determined myoblasts [5].
  • We show that transfection of 10T1/2 cells with DNA from these azacytidine-induced myoblasts (or from mouse C2C12 myoblasts) results in myogenic conversion of approximately 1 in 15,000 transfected colonies [5].
  • A further selection of cells after growth in agar allowed the isolation of Aza-treated clones that had regained the progressed phenotype [6].
  • Treatment of vimentin-negative BLCL and Langer-Giedion LCL with azacytidine led to a transient reexpression of vimentin [7].
  • It is in myotubes derived from myoblasts obtained by treatment of 10T1/2 cells with azacytidine or transfection with MRF4 [8].

Chemical compound and disease context of Azacitidine


Biological context of Azacitidine


Anatomical context of Azacitidine


Associations of Azacitidine with other chemical compounds


Gene context of Azacitidine


Analytical, diagnostic and therapeutic context of Azacitidine


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