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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L9HNO     2-[(E)-3,7,11,15,19,23,27...

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Disease relevance of ubiquinone-10


High impact information on ubiquinone-10


Chemical compound and disease context of ubiquinone-10


Biological context of ubiquinone-10


Anatomical context of ubiquinone-10

  • We conclude that activation of the oxidase enzyme complex in the intact neutrophil resulted in linkage of electron carrier function between endogenous ubiquinone-10 and cytochrome b559 and was without demonstrable effect on proximal electron flow [17].
  • Stopped-flow rapid-scan spectrophotometry was employed to study complicated oxidation processes of ubiquinol-cytochrome c reductase (QCR) that was purified from bovine heart mitochondria and maximally contained 0.36 mol of ubiquinone-10/mol of heme c1 [21].
  • A similar trend was observed in ubiquinone-10-enriched lymphocytes when compared with control cells [22].
  • In women only, NK cell cytotoxicity at different effector-target cell ratios was positively associated with plasma vitamin E and ubiquinone-10 concentrations (P < 0.05) [23].
  • Ubiquinone-10 has recently been proposed as a component of the microbicidal oxidase system of neutrophil leukocytes [Crawford & Schneider (1982) J. Biol. Chem. 257, 6662-6668] [24].

Associations of ubiquinone-10 with other chemical compounds


Gene context of ubiquinone-10


Analytical, diagnostic and therapeutic context of ubiquinone-10


  1. Asymmetric binding of the 1- and 4-C=O groups of QA in Rhodobacter sphaeroides R26 reaction centres monitored by Fourier transform infra-red spectroscopy using site-specific isotopically labelled ubiquinone-10. Brudler, R., de Groot, H.J., van Liemt, W.B., Steggerda, W.F., Esmeijer, R., Gast, P., Hoff, A.J., Lugtenburg, J., Gerwert, K. EMBO J. (1994) [Pubmed]
  2. Decreased serum ubiquinone-10 concentrations in phenylketonuria. Artuch, R., Vilaseca, M.A., Moreno, J., Lambruschini, N., Cambra, F.J., Campistol, J. Am. J. Clin. Nutr. (1999) [Pubmed]
  3. The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits. Djahansouzi, S., Braesen, J.H., Koenig, K., Beisiegel, U., Kontush, A. Atherosclerosis (2001) [Pubmed]
  4. Fission yeast decaprenyl diphosphate synthase consists of Dps1 and the newly characterized Dlp1 protein in a novel heterotetrameric structure. Saiki, R., Nagata, A., Uchida, N., Kainou, T., Matsuda, H., Kawamukai, M. Eur. J. Biochem. (2003) [Pubmed]
  5. Antioxidant vitamins in malnourished Nigerian children. Becker, K., Bötticher, D., Leichsenring, M. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1994) [Pubmed]
  6. Effect of an inhibitor of 3-hydroxy-3-methyglutaryl coenzyme A reductase on serum lipoproteins and ubiquinone-10-levels in patients with familial hypercholesterolemia. Mabuchi, H., Haba, T., Tatami, R., Miyamoto, S., Sakai, Y., Wakasugi, T., Watanabe, A., Koizumi, J., Takeda, R. N. Engl. J. Med. (1981) [Pubmed]
  7. Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia. 1981. Mabuchi, H., Haba, T., Tatami, R., Miyamoto, S., Sakai, Y., Wakasugi, T., Watanabe, A., Koizumi, J., Takeda, R. Atherosclerosis. Supplements. (2004) [Pubmed]
  8. Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Seo, B.B., Kitajima-Ihara, T., Chan, E.K., Scheffler, I.E., Matsuno-Yagi, A., Yagi, T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids. Neuzil, J., Witting, P.K., Stocker, R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Frei, B., Kim, M.C., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  11. Kinetic phases in the electron transfer from P+QA-QB to P+QAQB- and the associated processes in Rhodobacter sphaeroides R-26 reaction centers. Li, J., Gilroy, D., Tiede, D.M., Gunner, M.R. Biochemistry (1998) [Pubmed]
  12. FTIR spectroscopy shows weak symmetric hydrogen bonding of the QB carbonyl groups in Rhodobacter sphaeroides R26 reaction centres. Brudler, R., de Groot, H.J., van Liemt, W.B., Gast, P., Hoff, A.J., Lugtenburg, J., Gerwert, K. FEBS Lett. (1995) [Pubmed]
  13. Effect of replacing the primary quinone by different species on the ultrafast photosynthetic electron transfer in bacterial reaction centres. Logunov, S.L., Knox, P.P., Zakharova, N.I., Korvatovsky, B.N., Paschenko, V.Z., Kononenko, A.A. J. Photochem. Photobiol. B, Biol. (1990) [Pubmed]
  14. Preventive effect of a quinonyl derivative of N-acetylmuramyl dipeptide, QMDP-66, against adriamycin-induced ECG abnormalities in rats. Shimamoto, N., Tanabe, M., Shino, A., Hirata, M., Kawaji, H., Azuma, I., Fukuda, T., Kobayashi, S., Yamamura, Y. Int. J. Immunopharmacol. (1983) [Pubmed]
  15. Plasma phenylalanine is associated with decreased serum ubiquinone-10 concentrations in phenylketonuria. Artuch, R., Colomé, C., Vilaseca, M.A., Sierra, C., Cambra, F.J., Lambruschini, N., Campistol, J. J. Inherit. Metab. Dis. (2001) [Pubmed]
  16. Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Krähenbühl, S., Talos, C., Lauterburg, B.H., Reichen, J. Hepatology (1995) [Pubmed]
  17. Activation of the human neutrophil NADPH oxidase results in coupling of electron carrier function between ubiquinone-10 and cytochrome b559. Gabig, T.G., Lefker, B.A. J. Biol. Chem. (1985) [Pubmed]
  18. Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice. Witting, P.K., Pettersson, K., Letters, J., Stocker, R. Free Radic. Biol. Med. (2000) [Pubmed]
  19. The effects of lipid phase transitions on the interaction of mitochondrial NADH--ubiquinone oxidoreductase with ubiquinol--cytochrome c oxidoreductase. Heron, C., Gore, M.G., Ragan, C.I. Biochem. J. (1979) [Pubmed]
  20. Structural requirements of quinone coenzymes for endogenous and dye-mediated coupled electron transport in bacterial photosynthesis. Baccarini-Melandri, A., Gabellini, N., Melandri, B.A., Hurt, E., Hauska, G. J. Bioenerg. Biomembr. (1980) [Pubmed]
  21. Oxidation process of bovine heart ubiquinol-cytochrome c reductase as studied by stopped-flow rapid-scan spectrophotometry and simulations based on the mechanistic Q cycle model. Orii, Y., Miki, T. J. Biol. Chem. (1997) [Pubmed]
  22. Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Tomasetti, M., Littarru, G.P., Stocker, R., Alleva, R. Free Radic. Biol. Med. (1999) [Pubmed]
  23. Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged >/=90 y. Ravaglia, G., Forti, P., Maioli, F., Bastagli, L., Facchini, A., Mariani, E., Savarino, L., Sassi, S., Cucinotta, D., Lenaz, G. Am. J. Clin. Nutr. (2000) [Pubmed]
  24. The subcellular localization of ubiquinone in human neutrophils. Cross, A.R., Jones, O.T., Garcia, R., Segal, A.W. Biochem. J. (1983) [Pubmed]
  25. Lateral diffusion of ubiquinone during electron transfer in phospholipid- and ubiquinone-enriched mitochondrial membranes. Schneider, H., Lemasters, J.J., Hackenbrock, C.R. J. Biol. Chem. (1982) [Pubmed]
  26. The recognition of a special ubiquinone functionally central in the ubiquinone-cytochrome b-c2 oxidoreductase. Takamiya, K., Prince, R.C., Dutton, P.L. J. Biol. Chem. (1979) [Pubmed]
  27. The reconstitution of L-3-glycerophosphate-cytochrome c oxidoreductase from L-3-glycerophosphate dehydrogenase, ubiquinone-10 and ubiquinol-cytochrome c oxidoreductase. Cottingham, I.R., Ragan, C.I. Biochem. J. (1980) [Pubmed]
  28. Plasma ubiquinol-10 is decreased in patients with hyperlipidaemia. Kontush, A., Reich, A., Baum, K., Spranger, T., Finckh, B., Kohlschütter, A., Beisiegel, U. Atherosclerosis (1997) [Pubmed]
  29. Phenotypes of fission yeast defective in ubiquinone production due to disruption of the gene for p-hydroxybenzoate polyprenyl diphosphate transferase. Uchida, N., Suzuki, K., Saiki, R., Kainou, T., Tanaka, K., Matsuda, H., Kawamukai, M. J. Bacteriol. (2000) [Pubmed]
  30. Catalytic activity of complex I in cell lines that possess replacement mutations in the ND genes in Leber's hereditary optic neuropathy. Majander, A., Finel, M., Savontaus, M.L., Nikoskelainen, E., Wikström, M. Eur. J. Biochem. (1996) [Pubmed]
  31. Decreased plasma ubiquinone-10 concentration in patients with mevalonate kinase deficiency. Hübner, C., Hoffmann, G.F., Charpentier, C., Gibson, K.M., Finckh, B., Puhl, H., Lehr, H.A., Kohlschütter, A. Pediatr. Res. (1993) [Pubmed]
  32. Lipophilic antioxidants in patients with phenylketonuria. Colomé, C., Artuch, R., Vilaseca, M.A., Sierra, C., Brandi, N., Lambruschini, N., Cambra, F.J., Campistol, J. Am. J. Clin. Nutr. (2003) [Pubmed]
  33. Clinical and biochemical phenotype in 11 patients with mevalonic aciduria. Hoffmann, G.F., Charpentier, C., Mayatepek, E., Mancini, J., Leichsenring, M., Gibson, K.M., Divry, P., Hrebicek, M., Lehnert, W., Sartor, K. Pediatrics (1993) [Pubmed]
  34. The distribution of ubiquinone-10 in phospholipid bilayers. A study using differential scanning calorimetry. Katsikas, H., Quinn, P.J. Eur. J. Biochem. (1982) [Pubmed]
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