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Gene Review

AKAP8  -  A kinase (PRKA) anchor protein 8

Homo sapiens

Synonyms: A-kinase anchor protein 8, A-kinase anchor protein 95 kDa, AKAP 95, AKAP-8, AKAP-95, ...
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Disease relevance of AKAP8

  • A fragment covering amino acids 414-692 of human AKAP95 was expressed in Escherichia coli and shown to bind RIIalpha [1].
  • HA95, a nuclear protein homologous to AKAP95, has been identified in immune precipitates of the Epstein-Barr virus (EBV) coactivating nuclear protein EBNA-LP from EBV-transformed lymphoblastoid cells (LCLs) [2].

High impact information on AKAP8


Biological context of AKAP8


Anatomical context of AKAP8


Associations of AKAP8 with chemical compounds


Physical interactions of AKAP8

  • AKAP95 interacts with Xenopus XCAP-H condensin subunit in vitro and in vivo but not with the human hCAP-D2 subunit [10].
  • Competition with a peptide covering the RII-binding domain of AKAP Ht31 abolished RIIalpha binding to AKAP95 [1].

Co-localisations of AKAP8


Other interactions of AKAP8


Analytical, diagnostic and therapeutic context of AKAP8


  1. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Eide, T., Coghlan, V., Orstavik, S., Holsve, C., Solberg, R., Skâlhegg, B.S., Lamb, N.J., Langeberg, L., Fernandez, A., Scott, J.D., Jahnsen, T., Taskén, K. Exp. Cell Res. (1998) [Pubmed]
  2. Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins. Han, I., Xue, Y., Harada, S., Orstavik, S., Skalhegg, B., Kieff, E. Mol. Cell. Biol. (2002) [Pubmed]
  3. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Li, Y., Kao, G.D., Garcia, B.A., Shabanowitz, J., Hunt, D.F., Qin, J., Phelan, C., Lazar, M.A. Genes Dev. (2006) [Pubmed]
  4. A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract. Steen, R.L., Cubizolles, F., Le Guellec, K., Collas, P. J. Cell Biol. (2000) [Pubmed]
  5. Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication. Eide, T., Taskén, K.A., Carlson, C., Williams, G., Jahnsen, T., Taskén, K., Collas, P. J. Biol. Chem. (2003) [Pubmed]
  6. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. Collas, P., Le Guellec, K., Taskén, K. J. Cell Biol. (1999) [Pubmed]
  7. A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. Asirvatham, A.L., Galligan, S.G., Schillace, R.V., Davey, M.P., Vasta, V., Beavo, J.A., Carr, D.W. J. Immunol. (2004) [Pubmed]
  8. Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis. Landsverk, H.B., Carlson, C.R., Steen, R.L., Vossebein, L., Herberg, F.W., Taskén, K., Collas, P. J. Cell. Sci. (2001) [Pubmed]
  9. Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. Orstavik, S., Eide, T., Collas, P., Han, I.O., Taskén, K., Kieff, E., Jahnsen, T., Skålhegg, B.S. Biol. Cell (2000) [Pubmed]
  10. Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. Eide, T., Carlson, C., Taskén, K.A., Hirano, T., Taskén, K., Collas, P. EMBO Rep. (2002) [Pubmed]
  11. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. Furusawa, M., Taira, T., Iguchi-Ariga, S.M., Ariga, H. J. Biol. Chem. (2002) [Pubmed]
  12. A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase. Akileswaran, L., Taraska, J.W., Sayer, J.A., Gettemy, J.M., Coghlan, V.M. J. Biol. Chem. (2001) [Pubmed]
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