Gene Review:
AKAP1 - A kinase (PRKA) anchor protein 1
Homo sapiens
Synonyms:
A-kinase anchor protein 1, mitochondrial, A-kinase anchor protein 149 kDa, AKAP, AKAP 149, AKAP121, ...
- Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Nauert, J.B., Klauck, T.M., Langeberg, L.K., Scott, J.D. Curr. Biol. (1997)
- PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia. Rathee, P.K., Distler, C., Obreja, O., Neuhuber, W., Wang, G.K., Wang, S.Y., Nau, C., Kress, M. J. Neurosci. (2002)
- Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Baillie, G.S., Houslay, M.D. Curr. Opin. Cell Biol. (2005)
- AKAP mediated signal transduction. Michel, J.J., Scott, J.D. Annu. Rev. Pharmacol. Toxicol. (2002)
- cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Gao, T., Yatani, A., Dell'Acqua, M.L., Sako, H., Green, S.A., Dascal, N., Scott, J.D., Hosey, M.M. Neuron (1997)
- Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. Oliveria, S.F., Gomez, L.L., Dell'Acqua, M.L. J. Cell Biol. (2003)
- AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. Furusawa, M., Taira, T., Iguchi-Ariga, S.M., Ariga, H. J. Biol. Chem. (2002)
- AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. Yukitake, H., Furusawa, M., Taira, T., Iguchi-Ariga, S.M., Ariga, H. J. Biol. Chem. (2002)
- Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. Lin, R.Y., Moss, S.B., Rubin, C.S. J. Biol. Chem. (1995)
- Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. Steen, R.L., Martins, S.B., Taskén, K., Collas, P. J. Cell Biol. (2000)
- AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase. Steen, R.L., Beullens, M., Landsverk, H.B., Bollen, M., Collas, P. J. Cell. Sci. (2003)
- AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase. Furusawa, M., Ohnishi, T., Taira, T., Iguchi-Ariga, S.M., Ariga, H. J. Biol. Chem. (2001)
- NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. Huang, L.J., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T.J., Ellisman, M.H., Taylor, S.S. J. Cell Biol. (1999)
- RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. Lynch, M.J., Baillie, G.S., Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G., Houslay, M.D. J. Biol. Chem. (2005)
- Role of A kinase anchor proteins in the tissue-specific regulation of lipoprotein lipase. Ranganathan, G., Pokrovskaya, I., Ranganathan, S., Kern, P.A. Mol. Endocrinol. (2005)
- Increased phosphorylation of AKAP by inhibition of phosphatidylinositol 3-kinase enhances human sperm motility through tail recruitment of protein kinase A. Luconi, M., Carloni, V., Marra, F., Ferruzzi, P., Forti, G., Baldi, E. J. Cell. Sci. (2004)
- Association of PP1 with Its Regulatory Subunit AKAP149 Is Regulated by Serine Phosphorylation Flanking the RVXF Motif of AKAP149. Küntziger, T., Rogne, M., Folstad, R.L., Collas, P. Biochemistry (2006)
- Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Eide, T., Coghlan, V., Orstavik, S., Holsve, C., Solberg, R., Skâlhegg, B.S., Lamb, N.J., Langeberg, L., Fernandez, A., Scott, J.D., Jahnsen, T., Taskén, K. Exp. Cell Res. (1998)
- PKA-dependent binding of mRNA to the mitochondrial AKAP121 protein. Ginsberg, M.D., Feliciello, A., Jones, J.K., Avvedimento, E.V., Gottesman, M.E. J. Mol. Biol. (2003)
- Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. Herberg, F.W., Maleszka, A., Eide, T., Vossebein, L., Tasken, K. J. Mol. Biol. (2000)
- Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). Li, H., Adamik, R., Pacheco-Rodriguez, G., Moss, J., Vaughan, M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. Asirvatham, A.L., Galligan, S.G., Schillace, R.V., Davey, M.P., Vasta, V., Beavo, J.A., Carr, D.W. J. Immunol. (2004)
- Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. Schillace, R.V., Andrews, S.F., Liberty, G.A., Davey, M.P., Carr, D.W. J. Immunol. (2002)
- Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. Dransfield, D.T., Bradford, A.J., Smith, J., Martin, M., Roy, C., Mangeat, P.H., Goldenring, J.R. EMBO J. (1997)
- Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. Reinton, N., Collas, P., Haugen, T.B., Skâlhegg, B.S., Hansson, V., Jahnsen, T., Taskén, K. Dev. Biol. (2000)
- Occurrence of A-kinase anchor protein and associated cAMP-dependent protein kinase in the inner compartment of mammalian mitochondria. Sardanelli, A.M., Signorile, A., Nuzzi, R., Rasmo, D.D., Technikova-Dobrova, Z., Drahota, Z., Occhiello, A., Pica, A., Papa, S. FEBS Lett. (2006)