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Gene Review

BATF  -  basic leucine zipper transcription factor,...

Homo sapiens

Synonyms: B-ATF, B-cell-activating transcription factor, BATF1, Basic leucine zipper transcriptional factor ATF-like, SF-HT-activated gene 2 protein, ...
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Disease relevance of BATF

  • In this study, we identified BATF as a cellular gene that is up-regulated dramatically within 24 h following the infection of established and primary human B cells with EBV [1].
  • Northern blot analysis of polyadenylated mRNA isolated from a variety of human tissues and established cell lines indicates that the 1.0 kilobase B-ATF mRNA is expressed differentially, with the strongest hybridization detected in lung and in Raji Burkitt's lymphoma [2].
  • A novel cellular gene, SFA-2, was isolated by differential hybridization of a cDNA library, using probes obtained from an adult T-cell leukemia cell line in comparison with normal CD4+ T cells and MOLT-4 cell line [3].

High impact information on BATF

  • Intriguingly, the induction of AP-1 activity by LPS in precursor B cells and primary dendritic cells fully depends on the IKK/NF-kappaB pathway, which promotes expression of several AP-1 family members, including JunB, JunD, and B-ATF [4].
  • In this study, we show that Tg BATF targets the majority of Valpha14Jalpha281 (Valpha14i(7)) NKT cells, regardless of CD4 expression and Vbeta gene usage [5].
  • As a population, BATF-expressing NKT cells are TCRbeta/CD3epsilon(low), but express normal levels of CD69, suggesting a failure to expand appropriately following selection [5].
  • Interaction studies in vitro and in vivo show that the leucine zipper of B-ATF mediates dimerization with members of the Jun family of proteins [6].
  • Stable expression of B-ATF in C3H10T1/2 cells does not reduce cell viability, but does result in a reduced cellular growth rate when compared to controls [6].

Biological context of BATF

  • Given that 40% of mammalian bZIP transcription factors contain a residue analogous to serine-43 of BATF in their DNA binding domains, the phosphorylation event described here represents a mechanism that is potentially applicable to the regulation of many bZIP proteins [7].
  • The identification of BATF as a cellular target of EBV provides important new information on how programs of viral and cellular gene expression may be coordinated to promote viral latency and control lytic-cycle entry [1].
  • The transactivation of BATF is mediated by EBNA2 in a B-cell-specific manner and is duplicated in non-EBV-infected B cells by the expression of mammalian Notch proteins [1].
  • A potential role for BATF in promoting EBV latency is supported by studies in which BATF was shown to negatively impact the expression of a BZLF1 reporter gene and to reduce the frequency of lytic replication in latently infected cells [1].
  • A new member of the ATF/CREB family of transcription factors, called B-ATF, has been isolated from a cDNA library prepared from Epstein-Barr virus stimulated human B cells [2].

Anatomical context of BATF

  • Frequency-dependent changes in modulus and phase of BATF and RATF were attributable to wave travel and reflection in the upper limb [8].
  • SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes [3].

Associations of BATF with chemical compounds


Physical interactions of BATF

  • These data demonstrate that phosphorylation of serine-43 converts BATF from a DNA binding into a non-DNA binding inhibitor of AP-1 activity [7].
  • IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors [9].

Regulatory relationships of BATF


Other interactions of BATF

  • Interestingly, BATF(S43D) functions like wild-type BATF to reduce AP-1-mediated gene transcription, despite the observed inability of the BATF(S43D):Jun heterodimer to bind DNA [7].

Analytical, diagnostic and therapeutic context of BATF

  • Northern blot analysis reveals that the human B-ATF gene is expressed most highly in hematopoietic tissues [6].


  1. EBNA2 and activated Notch induce expression of BATF. Johansen, L.M., Deppmann, C.D., Erickson, K.D., Coffin, W.F., Thornton, T.M., Humphrey, S.E., Martin, J.M., Taparowsky, E.J. J. Virol. (2003) [Pubmed]
  2. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Dorsey, M.J., Tae, H.J., Sollenberger, K.G., Mascarenhas, N.T., Johansen, L.M., Taparowsky, E.J. Oncogene (1995) [Pubmed]
  3. SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. Hasegawa, H., Utsunomiya, Y., Kishimoto, K., Tange, Y., Yasukawa, M., Fujita, S. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  4. The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1. Krappmann, D., Wegener, E., Sunami, Y., Esen, M., Thiel, A., Mordmuller, B., Scheidereit, C. Mol. Cell. Biol. (2004) [Pubmed]
  5. Sensitivity of NK1.1-Negative NKT Cells to Transgenic BATF Defines a Role for Activator Protein-1 in the Expansion and Maturation of Immature NKT Cells in the Thymus. Zullo, A.J., Benlagha, K., Bendelac, A., Taparowsky, E.J. J. Immunol. (2007) [Pubmed]
  6. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. Echlin, D.R., Tae, H.J., Mitin, N., Taparowsky, E.J. Oncogene (2000) [Pubmed]
  7. Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation. Deppmann, C.D., Thornton, T.M., Utama, F.E., Taparowsky, E.J. Biochem. J. (2003) [Pubmed]
  8. An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man. Karamanoglu, M., O'Rourke, M.F., Avolio, A.P., Kelly, R.P. Eur. Heart J. (1993) [Pubmed]
  9. IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. Wang, X., Johansen, L.M., Tae, H.J., Taparowsky, E.J. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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