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Gene Review

SLC22A7  -  solute carrier family 22 (organic anion...

Homo sapiens

Synonyms: NLT, Novel liver transporter, OAT2, Organic anion transporter 2, Solute carrier family 22 member 7, ...
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High impact information on SLC22A7


Biological context of SLC22A7


Anatomical context of SLC22A7


Associations of SLC22A7 with chemical compounds


Other interactions of SLC22A7

  • The effects of OAT inhibitors on OAT1, OAT2, and OAT3 exhibited some but not so remarkable interspecies differences between humans and rats [12].
  • We further isolated homologs of OAT series such as liver-specific OAT2 and kidney-, liver- and brain-expressing OAT3 [13].
  • The levels of Mrp2, Oat1 and Oat2 on day 1 after the treatment showed no significant change [14].
  • Short interfering RNAs inhibiting endogenous HNF-4 alpha expression markedly reduced endogenous expression of hOAT2 in Huh7 cells [1].


  1. The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids. Popowski, K., Eloranta, J.J., Saborowski, M., Fried, M., Meier, P.J., Kullak-Ublick, G.A. Mol. Pharmacol. (2005) [Pubmed]
  2. A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. Tahara, H., Kusuhara, H., Endou, H., Koepsell, H., Imaoka, T., Fuse, E., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  3. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. Enomoto, A., Takeda, M., Shimoda, M., Narikawa, S., Kobayashi, Y., Kobayashi, Y., Yamamoto, T., Sekine, T., Cha, S.H., Niwa, T., Endou, H. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  4. Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2-->p21.1 using radiation hybrids. Kok, L.D., Siu, S.S., Fung, K.P., Tsui, S.K., Lee, C.Y., Waye, M.M. Cytogenet. Cell Genet. (2000) [Pubmed]
  5. Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). Kobayashi, Y., Ohshiro, N., Sakai, R., Ohbayashi, M., Kohyama, N., Yamamoto, T. J. Pharm. Pharmacol. (2005) [Pubmed]
  6. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. Sekine, T., Cha, S.H., Tsuda, M., Apiwattanakul, N., Nakajima, N., Kanai, Y., Endou, H. FEBS Lett. (1998) [Pubmed]
  7. A micromorphological and histoenzymological study on the third ventricular ependyma of the teleost Clarias batrachus (L.). Sathyanesan, A.G., Joy, K.P. Zeitschrift für mikroskopisch-anatomische Forschung. (1978) [Pubmed]
  8. Isolation of a family of organic anion transporters from human liver and kidney. Sun, W., Wu, R.R., van Poelje, P.D., Erion, M.D. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  9. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Jigorel, E., Le Vee, M., Boursier-Neyret, C., Parmentier, Y., Fardel, O. Drug Metab. Dispos. (2006) [Pubmed]
  10. Human organic anion transporters mediate the transport of tetracycline. Babu, E., Takeda, M., Narikawa, S., Kobayashi, Y., Yamamoto, T., Cha, S.H., Sekine, T., Sakthisekaran, D., Endou, H. Jpn. J. Pharmacol. (2002) [Pubmed]
  11. Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide. Kobayashi, Y., Ohbayashi, M., Kohyama, N., Yamamoto, T. Eur. J. Pharmacol. (2005) [Pubmed]
  12. Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. Khamdang, S., Takeda, M., Shimoda, M., Noshiro, R., Narikawa, S., Huang, X.L., Enomoto, A., Piyachaturawat, P., Endou, H. J. Pharmacol. Sci. (2004) [Pubmed]
  13. Recent advances in molecular mechanisms of nephrotoxicity. Endou, H. Toxicol. Lett. (1998) [Pubmed]
  14. Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats. Shibayama, Y., Ushinohama, K., Ikeda, R., Yoshikawa, Y., Motoya, T., Takeda, Y., Yamada, K. Cancer Sci. (2006) [Pubmed]
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