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Gene Review

MMP24  -  matrix metallopeptidase 24 (membrane...

Homo sapiens

Synonyms: MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, ...
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Disease relevance of MMP24


High impact information on MMP24

  • Despite their difference in mediating proMMP-2 activation in transfected cells, the CAT of MT6-MMP appears to be as efficient as that of MT5-MMP in cleaving proMMP-2EA in buffer, suggesting that its CAT is a strong proMMP-2 activator [5].
  • On the basis of these features, this novel human MMP has been called MT5-MMP because it represents the fifth member of the MT-MMP subfamily of MMPs [2].
  • Northern blot analysis demonstrated that MT5-MMP is predominantly expressed in brain, kidney, pancreas, and lung [2].
  • In addition, MT5-MMP transcripts were detected at high levels compared to normal brain tissue in a series of brain tumors, including astrocytomas and glioblastomas [2].
  • Furthermore, the tubular epithelial cells that expressed MT5-MMP were associated with tubular atrophy [1].

Biological context of MMP24

  • Here we report on mRNA and protein expression of the fifth human MT-MMP (MT5-MMP), a 64-kDa protein that is capable of converting pro-MMP-2 to its active form, in human kidney as well as its upregulation in diabetes [1].
  • cDNA clones of MT5-matrix metalloproteinase (MT5-MMP) and a related protein (designated MT5-MMP-del) were isolated by screening the cDNA library and by 3'-rapid amplification of cDNA ends using an ovary RNA of the medaka fish Oryzias latipes [6].

Anatomical context of MMP24


Other interactions of MMP24


Analytical, diagnostic and therapeutic context of MMP24


  1. Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients. Romanic, A.M., Burns-Kurtis, C.L., Ao, Z., Arleth, A.J., Ohlstein, E.H. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  2. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. Llano, E., Pendás, A.M., Freije, J.P., Nakano, A., Knäuper, V., Murphy, G., López-Otin, C. Cancer Res. (1999) [Pubmed]
  3. Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis. García-Alvarez, J., Ramirez, R., Sampieri, C.L., Nuttall, R.K., Edwards, D.R., Selman, M., Pardo, A. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders. (2006) [Pubmed]
  4. Gingival crevicular fluid matrix metalloproteinase-25 and -26 levels in periodontal disease. Emingil, G., Kuula, H., Sorsa, T., Atilla, G. J. Periodontol. (2006) [Pubmed]
  5. Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond. Nie, J., Pei, D. Cancer Res. (2003) [Pubmed]
  6. Expression and localization of transcripts of MT5-MMP and its related MMP in the ovary of the medaka fish Oryzias latipes. Kimura, A., Shinohara, M., Ohkura, R., Takahashi, T. Biochim. Biophys. Acta (2001) [Pubmed]
  7. Immunoscreening of a cutaneous T-cell lymphoma library for plasma membrane proteins. Lee, M., Kistler, C., Hartmann, T.B., Li, F., Dummer, R., Dippel, E., Booken, N., Klemke, C.D., Schadendorf, D., Eichmüller, S.B. Cancer Immunol. Immunother. (2007) [Pubmed]
  8. Tissue mRNA expression in rat of newly described matrix metalloproteinases. Bernal, F., Hartung, H.P., Kieseier, B.C. Biol. Res. (2005) [Pubmed]
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