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Gene Review

EIF2D  -  eukaryotic translation initiation factor 2D

Homo sapiens

Synonyms: Eukaryotic translation initiation factor 2D, HCA56, Hepatocellular carcinoma-associated antigen 56, LGTN, Ligatin, ...
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High impact information on LGTN


Biological context of LGTN

  • The clone was isolated from a human U937 promonocyte lambda gt11 cDNA library using rabbit antiserum to rat ileal ligatin [2].
  • The 225 bases of coding sequence correspond to the carboxyl region of ligatin and contain a potential acceptor site for asparagine-linked glycosylation [2].
  • A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion [3].

Anatomical context of LGTN


Associations of LGTN with chemical compounds

  • Ligatin exists as a filament that can be released from membranes still complexed with its bound hydrolases by treatment of membrane preparations with CaCl2 and/or pH 8 [4].
  • Ligatin can be released from intact, embryonic chick neural retinal cells by treatment with 20 mM Ca++ without adversely affecting their viability, alpha-Glucose-1-phosphate is also effective in removing ligatin-associated glycoproteins from intact cells [3].
  • The effectiveness of these two phosphomonosaccharides varied depending on the source of the enzyme: ileal beta-NAG-ligatin complexes showed a four-fold preferential dissociation with Man6P; macrophage complexes showed a 160-fold preferential dissociation with Glc 1P [5].
  • Treatment of the solubilized hydrolases with endoglucosaminidase H released phosphorous-32 label from these enzymes and prevented binding of beta-NAG to ligatin [5].
  • Isolated reactive transfectants were sequenced and 42 different genes identified including four known plasma membrane proteins: Ligatin, HLA-A, integrin alpha4 and MT5-MMP [6].

Analytical, diagnostic and therapeutic context of LGTN


  1. Ligatin: a peripheral membrane protein with covalently bound palmitic acid. Jakoi, E.R., Ross, P.E., Ping Ting-Beall, H., Kaufman, B., Vanaman, T.C. J. Biol. Chem. (1987) [Pubmed]
  2. Molecular cloning of the cDNA for ligatin. Jakoi, E.R., Brown, A.L., Ho, Y.S., Snyderman, R. J. Cell. Sci. (1989) [Pubmed]
  3. A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion. Marchase, R.B., Koro, L.A., Kelly, C.M., McClay, D.R. J. Cell. Biochem. (1982) [Pubmed]
  4. Brain ligatin: a membrane lectin that binds acetylcholinesterase. Gaston, S.M., Marchase, R.B., Jakoi, E.R. J. Cell. Biochem. (1982) [Pubmed]
  5. Ligatin binds phosphohexose residues on acidic hydrolases. Jakoi, E.R., Kempe, K., Gaston, S.M. Journal of supramolecular structure and cellular biochemistry. (1981) [Pubmed]
  6. Immunoscreening of a cutaneous T-cell lymphoma library for plasma membrane proteins. Lee, M., Kistler, C., Hartmann, T.B., Li, F., Dummer, R., Dippel, E., Booken, N., Klemke, C.D., Schadendorf, D., Eichmüller, S.B. Cancer Immunol. Immunother. (2007) [Pubmed]
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