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Pgia1  -  proteoglycan induced arthritis 1

Mus musculus

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Disease relevance of Pgia1


High impact information on Pgia1

  • CONCLUSION: These findings indicate that IL-4 functions as a major antiinflammatory cytokine in PGIA by governing the activity of macrophages/neutrophils and less so by controlling T cell activity and autoantibody isotype expression [5].
  • RESULTS: Between the onset of arthritis and the beginning of the destructive phase of PGIA, we found a steady increase in the number of leukocytes that exhibited firm adherence to the endothelium of synovial vessels, which clearly underscores the chronic, self-perpetuating character of joint inflammation in this autoimmune model [6].
  • METHODS: We used intravital video microscopy (IVM), which was adapted to the microcirculation of the mouse ankle, to monitor the kinetics of leukocyte-endothelium interactions (rolling and firm adhesion) during the onset and progression of proteoglycan-induced arthritis (PGIA), a chronic autoimmune model of RA [6].
  • Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice [7].
  • However, this was not associated with enhanced T or B cell responses to cartilage PGs, but rather, an early and more extensive infiltration of the synovium with neutrophil leukocytes was the most prominent histopathologic feature of PGIA in Tnfip6-deficient mice [7].

Biological context of Pgia1


Anatomical context of Pgia1


Associations of Pgia1 with chemical compounds


Other interactions of Pgia1


Analytical, diagnostic and therapeutic context of Pgia1


  1. A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis. Otto, J.M., Chandrasekeran, R., Vermes, C., Mikecz, K., Finnegan, A., Rickert, S.E., Enders, J.T., Glant, T.T. J. Immunol. (2000) [Pubmed]
  2. Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease. Glant, T.T., Bárdos, T., Vermes, C., Chandrasekaran, R., Valdéz, J.C., Otto, J.M., Gerard, D., Velins, S., Lovász, G., Zhang, J., Mikecz, K., Finnegan, A. Arthritis Rheum. (2001) [Pubmed]
  3. Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis. Dayer, E., Mathai, L., Glant, T.T., Mikecz, K., Poole, A.R. Arthritis Rheum. (1990) [Pubmed]
  4. Animal models of spondyloarthritis. Lories, R.J. Current opinion in rheumatology. (2006) [Pubmed]
  5. Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Cao, Y., Brombacher, F., Tunyogi-Csapo, M., Glant, T.T., Finnegan, A. Arthritis Rheum. (2007) [Pubmed]
  6. Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis. Gál, I., Bajnok, E., Szántó, S., Sarraj, B., Glant, T.T., Mikecz, K. Arthritis Rheum. (2005) [Pubmed]
  7. Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice. Szántó, S., Bárdos, T., Gál, I., Glant, T.T., Mikecz, K. Arthritis Rheum. (2004) [Pubmed]
  8. Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis. Otto, J.M., Cs-Szabó, G., Gallagher, J., Velins, S., Mikecz, K., Buzás, E.I., Enders, J.T., Li, Y., Olsen, B.R., Glant, T.T. Arthritis Rheum. (1999) [Pubmed]
  9. Characterization of proteoglycan-reactive T cell lines and hybridomas from mice with proteoglycan-induced arthritis. Leroux, J.Y., Poole, A.R., Webber, C., Vipparti, V., Choi, H.U., Rosenberg, L.C., Banerjee, S. J. Immunol. (1992) [Pubmed]
  10. Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Brennan, F.R., Negroiu, G., Buzás, E.I., Fülöp, C., Holló, K., Mikecz, K., Glant, T.T. Clin. Exp. Immunol. (1995) [Pubmed]
  11. Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Brennan, F.R., Mikecz, K., Buzás, E.I., Ragasa, D., Cs-Szabó, G., Negroiu, G., Glant, T.T. Clin. Exp. Immunol. (1995) [Pubmed]
  12. CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis. Bardos, T., Czipri, M., Vermes, C., Finnegan, A., Mikecz, K., Zhang, J. Arthritis Res. Ther. (2003) [Pubmed]
  13. Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype. Hanyecz, A., Berlo, S.E., Szántó, S., Broeren, C.P., Mikecz, K., Glant, T.T. Arthritis Rheum. (2004) [Pubmed]
  14. Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide. Glant, T.T., Mikecz, K., Bartlett, R.R., Deák, F., Thonar, E.J., Williams, J.M., Mattar, T., Kuettner, K.E., Schleyerbach, R. Immunopharmacology (1992) [Pubmed]
  15. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. Finnegan, A., Grusby, M.J., Kaplan, C.D., O'Neill, S.K., Eibel, H., Koreny, T., Czipri, M., Mikecz, K., Zhang, J. J. Immunol. (2002) [Pubmed]
  16. Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis. Glant, T.T., Adarichev, V.A., Nesterovitch, A.B., Szanto, S., Oswald, J.P., Jacobs, J.J., Firneisz, G., Zhang, J., Finnegan, A., Mikecz, K. Am. J. Med. Sci. (2004) [Pubmed]
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