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MeSH Review


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Disease relevance of Spondylitis


High impact information on Spondylitis


Chemical compound and disease context of Spondylitis

  • Tuberculous spondylitis as a complication of intravesical bacillus Calmette-Guerin therapy [4].
  • HLA-B27 has an unpaired cysteine on or near its serologically defined spondylitis associated epitope, and it has been argued that its sulphydryl side chain may be chemically reactive [9].
  • Despite the paucity of other rheumatic symptoms a diagnosis of Reiter's syndrome with spondylitis was made, and the only surgical procedure required was posterior fusion of C1 and C2, with resultant spinal stability and pain relief [10].
  • In order to investigate the proposed involvement of neuropeptides in musculoskeletal inflammation we pretreated rats, in an adjuvant spondylitis model, with capsaicin, a neurotoxin [11].
  • No persistent side effects were observed, and naproxen appears to be a useful drug in the treatment of anklyosing spondylitis [12].

Anatomical context of Spondylitis

  • This association of ankylosing spondylitis with the T cell and protein abnormalities is probably fortuitous but does demonstrate that severe spondylitis may evolve in the absence of IgA [13].
  • In patients with chronic infectious spondylitis, diffuse reactive bone marrow changes with decreased signal intensity on T1-weighted images, increased signal intensity on T2-weighted and STIR images, and increased uptake after gadolinium administration may occur [14].

Gene context of Spondylitis


Analytical, diagnostic and therapeutic context of Spondylitis


  1. Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo. Leroux, J.Y., Guerassimov, A., Cartman, A., Delaunay, N., Webber, C., Rosenberg, L.C., Banerjee, S., Poole, A.R. J. Clin. Invest. (1996) [Pubmed]
  2. Long-term outcome of mothers of children with complete congenital heart block. Press, J., Uziel, Y., Laxer, R.M., Luy, L., Hamilton, R.M., Silverman, E.D. Am. J. Med. (1996) [Pubmed]
  3. Do the radiological changes of classic ankylosing spondylitis differ from the changes found in the spondylitis associated with inflammatory bowel disease, psoriasis, and reactive arthritis? Helliwell, P.S., Hickling, P., Wright, V. Ann. Rheum. Dis. (1998) [Pubmed]
  4. Tuberculous spondylitis as a complication of intravesical bacillus Calmette-Guerin therapy. Fishman, J.R., Walton, D.T., Flynn, N.M., Benson, D.R., deVere White, R.W. J. Urol. (1993) [Pubmed]
  5. Fluorine-18 fluorodeoxyglucose PET in infectious bone diseases: results of histologically confirmed cases. Kälicke, T., Schmitz, A., Risse, J.H., Arens, S., Keller, E., Hansis, M., Schmitt, O., Biersack, H.J., Grünwald, F. European journal of nuclear medicine. (2000) [Pubmed]
  6. Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy. Végvári, A., Szabó, Z., Szántó, S., Nesterovitch, A.B., Mikecz, K., Glant, T.T., Adarichev, V.A. J. Immunol. (2005) [Pubmed]
  7. Characterization of proteoglycan-reactive T cell lines and hybridomas from mice with proteoglycan-induced arthritis. Leroux, J.Y., Poole, A.R., Webber, C., Vipparti, V., Choi, H.U., Rosenberg, L.C., Banerjee, S. J. Immunol. (1992) [Pubmed]
  8. Drug-induced hepatocellular liver injury due to benzylpenicillin with evidence of lymphocyte sensitization. Bauer, T.M., Bircher, A.J. J. Hepatol. (1997) [Pubmed]
  9. Sulphydryl reactivity of the HLA-B27 epitope: accessibility of the free cysteine studied by flow cytometry. MacLean, L., Macey, M., Lowdell, M., Badakere, S., Whelan, M., Perrett, D., Archer, J. Ann. Rheum. Dis. (1992) [Pubmed]
  10. Spontaneous atlantoaxial subluxation: an unusual presenting manifestation of Reiter's syndrome. Melsom, R.D., Benjamin, J.C., Barnes, C.G. Ann. Rheum. Dis. (1989) [Pubmed]
  11. Neonatal capsaicin pretreatment suppresses intramedullary inflammation in adjuvant-induced spondylitis. Imai, S., Hukuda, S., Maeda, T. Clin. Exp. Immunol. (1994) [Pubmed]
  12. Ankylosing spondylitis: open long-term and double-blind crossover studies with naproxen. Hill, H.F., Hill, A.G. Journal of clinical pharmacology. (1975) [Pubmed]
  13. Ankylosing spondylitis with selective IgA deficiency and a circulating anticoagulant. Good, A.E., Cassidy, J.T., Mutchnick, M.G., Reed, R.E., Lederman, H.M. J. Rheumatol. (1977) [Pubmed]
  14. Imaging of spinal infection. Stäbler, A., Reiser, M.F. Radiol. Clin. North Am. (2001) [Pubmed]
  15. Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease. Peeters, H., Vander Cruyssen, B., Laukens, D., Coucke, P., Marichal, D., Van Den Berghe, M., Cuvelier, C., Remaut, E., Mielants, H., De Keyser, F., Vos, M.D. Ann. Rheum. Dis. (2004) [Pubmed]
  16. Animal models of inflammatory spinal and sacroiliac joint diseases. Zhang, Y. Rheum. Dis. Clin. North Am. (2003) [Pubmed]
  17. Methotrexate for ankylosing spondylitis. Chen, J., Liu, C. Cochrane database of systematic reviews (Online) (2004) [Pubmed]
  18. Experimental immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies. Shi, S., Ciurli, C., Cartman, A., Pidoux, I., Poole, A.R., Zhang, Y. Arthritis Rheum. (2003) [Pubmed]
  19. Bone scanning in lumbar disc herniation. Johansen, J.P., Fossgreen, J., Hansen, H.H. Acta orthopaedica Scandinavica. (1980) [Pubmed]
  20. Early diagnosis of infective spondylitis with Gallium-67. Dux, S., Halevi, J., Pitlik, S., Rosenfeld, J.B. Isr. J. Med. Sci. (1981) [Pubmed]
  21. 18F-FDG hybrid PET in patients with suspected spondylitis. Gratz, S., Dörner, J., Fischer, U., Behr, T.M., Béhé, M., Altenvoerde, G., Meller, J., Grabbe, E., Becker, W. Eur. J. Nucl. Med. Mol. Imaging (2002) [Pubmed]
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